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ACCN1/ASIC2 (ASIC2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1753095

Description: Rabbit IgG polyclonal antibody for ACCN1/ASIC2 detection. Tested with WB, ICC/IF, FCM, Direct ELISA in Human; Mouse; Rat.Background: Amiloride-sensitive cation channel 1, neuronal, also known as ASIC2, is a protein that in humans is encoded… More details

$210 / 0.01 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ACCN1/ASIC2, Polyclonal Antibody
Full Product Name
Anti-ACCN1/ASIC2 Antibody
Product Gene Name
anti-ASIC2 antibody
Product Synonym Names
Acid-sensing ion channel 2; ASIC2; Amiloride-sensitive brain sodium channel; Amiloride-sensitive cation channel 1, neuronal; Amiloride-sensitive cation channel neuronal 1; Brain sodium channel 1; BNC1; BNaC1; Mammalian degenerin homolog; MDEG; ASIC2; ACCN, ACCN1, BNAC1, MDEG
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen affinity purified.
Specificity
No cross reactivity with other proteins.
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.
OMIM
U50352 mRNA
3D Structure
ModBase 3D Structure for Q16515
Immunogen
E Coli-derived human ACCN1/ASIC2 recombinant protein (Position: H27-C512).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-ASIC2 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), Direct ELISA (EIA)
Application Notes for anti-ASIC2 antibody
WB: 0.1-0.25ug/ml (Human, Mouse, Rat)
ICC: 2ug/ml (Human)
IF: 2ug/ml (Human)
FC/FACS: 1-3ug/1x106 cells (Human)
Direct ELISA: 0.1-0.5ug/ml (Human)
Tested Species: In-house tested species with positive results.

Flow Cytometry (FC/FACS) of anti-ASIC2 antibody

Rabbit Anti-ASIC2 Polyclonal Antibody – Cat# MBS1753095

Flow Cytometry (FC/FACS) of anti-ASIC2 antibody

Rabbit Anti-ASIC2 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS1753095

Immunofluorescence (IF) of anti-ASIC2 antibody

Rabbit Anti-ASIC2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS1753095

Western Blot (WB) of anti-ASIC2 antibody

Figure 1. Western blot analysis of ASIC2 using anti-ASIC2 antibody.
Rabbit Anti-ASIC2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS1753095

Product References and Citations for anti-ASIC2 antibody

1. Garcia-Anoveros, J., Derfler, B., Neville-Golden, J., Hyman, B. T., Corey, D. P. BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proc. Nat. Acad. Sci. 94: 1459-1464, 1997.
2. Jahr, H., van Driel, M., van Osch, G. J. V. M., Weinans, H., van Leeuwen, J. P. T. M. Identification of acid-sensing ion channels in bone. Biochem. Biophys. Res. Commun. 337: 349-354, 2005.
3. Lu, Y., Ma, X., Sabharwal, R., Snitsarev, V., Morgan, D., Rahmouni, K., Drummond, H. A., Whiteis, C. A., Costa, V., Price, M., Benson, C., Welsh, M. J., Chapleau, M. W., Abboud, F. M. The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation. Neuron 64: 885-897, 2009.

Other Notes

Small volumes of anti-ASIC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ASIC2 purchase

MBS1753095 is an antibody targeting ASIC2. Also known as Anti-ACCN1/ASIC2 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ASIC2. It may not necessarily be applicable to this product.

NCBI GI #
9998944
NCBI GeneID
40
NCBI Accession #
NP_001085.2
UniProt Primary Accession #
Q16515
UniProt Related Accession #
Q16515
GenBank Nucleotide #
NP_001085.2
NCBI Official Full Name
acid-sensing ion channel 2 isoform MDEG1
NCBI Official Synonym Full Names
acid sensing ion channel subunit 2
NCBI Official Symbol
ASIC2
NCBI Official Synonym Symbols
ACCN; BNC1; MDEG; ACCN1; BNaC1; ASIC2a; hBNaC1
UniProt Protein Name
Acid-sensing ion channel 2
UniProt Synonym Protein Names
Amiloride-sensitive brain sodium channel; Amiloride-sensitive cation channel 1, neuronal; Amiloride-sensitive cation channel neuronal 1; Brain sodium channel 1; BNC1; BNaC1; Mammalian degenerin homolog
Protein Family
Acid-sensing ion channel
UniProt Gene Name
ASIC2
UniProt Synonym Gene Names
ACCN; ACCN1; BNAC1; MDEG; ASIC2; BNC1; BNaC1
NCBI Protein Information
acid-sensing ion channel 2

NCBI Summary for ASIC2

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]
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UniProt Comments for ASIC2

ASIC2: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: 17q11.2-q12

Cellular Component: plasma membrane

Molecular Function: amiloride-sensitive sodium channel activity; protein binding

Biological Process: central nervous system development; monovalent inorganic cation transport; peripheral nervous system development; regulation of blood coagulation; regulation of gene expression; sensory perception of sour taste; synaptic transmission
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Research Articles on ASIC2

1. Analysis of human autoptic brain tissue in multiple sclerosis (MS) and control samples showed an increase of ASIC 2 mRNA in MS samples.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ASIC2 antibody

 Reference Product  PubMed Publications
 ACCN3 antibody  >1 publications with ASIC2 and ACCN3

Pathways associated with anti-ASIC2 antibody

 Products by Pathway  Pathway Diagram
 Taste Transduction Pathway antibodies  Taste Transduction Pathway Diagram
 Taste Transduction Pathway antibodies  Taste Transduction Pathway Diagram

Diseases associated with anti-ASIC2 antibody

 Disease Name  Pubmed Publications
 Genetic Diseases, Inborn Antibodies  >4 publications with ASIC2 and Genetic Diseases, Inborn
 Congenital Abnormalities Antibodies  >2 publications with ASIC2 and Congenital Abnormalities
 Skin Neoplasms Antibodies  >1 publications with ASIC2 and Skin Neoplasms
 Thrombosis Antibodies  >1 publications with ASIC2 and Thrombosis
 Venous Thrombosis Antibodies  >1 publications with ASIC2 and Venous Thrombosis
 Acidosis Antibodies  >1 publications with ASIC2 and Acidosis
 Panic Disorder Antibodies  >1 publications with ASIC2 and Panic Disorder
 Chromosome Breakage Antibodies  >1 publications with ASIC2 and Chromosome Breakage
 Autistic Disorder Antibodies  >1 publications with ASIC2 and Autistic Disorder

Organs/Tissues associated with anti-ASIC2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with ASIC2 and Brain
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