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Sprouty 4/Spry-4/SPRY4 (SPRY4) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1753106

Description: Rabbit IgG polyclonal antibody for Sprouty 4/Spry-4/SPRY4 detection. Tested with WB, FCM, Direct ELISA in Human.Background: Protein sprouty homolog 4 is a protein that in humans is encoded by the SPRY4 gene. It is mapped to 5q31.3. This gene… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Sprouty 4/Spry-4/SPRY4, Polyclonal Antibody
Full Product Name
Anti-Sprouty 4/Spry-4/SPRY4 Antibody
Product Gene Name
anti-SPRY4 antibody
Product Synonym Names
Protein sprouty homolog 4; Spry-4; SPRY4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen affinity purified.
Specificity
No cross reactivity with other proteins.
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.
OMIM
607984
3D Structure
ModBase 3D Structure for Q9C004
Immunogen
E Coli-derived human Sprouty 4/Spry-4/SPRY4 recombinant protein (Position: M1-K297).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-SPRY4 antibody
Western Blot (WB), Flow Cytometry (FC/FACS), Direct ELISA (EIA)
Application Notes for anti-SPRY4 antibody
WB: 0.25-0.5ug/ml (Human)
FC/FACS: 1-3ug/1x106 cells (Human)
Direct ELISA: 0.1-0.5ug/ml (Human)
Tested Species: In-house tested species with positive results.

Product References and Citations for anti-SPRY4 antibody

1. Khaitan, D., Dinger, M. E., Mazar, J., Crawford, J., Smith, M. A., Mattick, J. S., Perera, R. J. The melanoma-upregulated long noncoding RNA SPRY4-IT1 modulates apoptosis and invasion. Cancer Res. 71: 3852-3862, 2011.
2. Klein, O. D., Minowada, G., Peterkova, R., Kangas, A., Yu, B. D., Lesot, H., Peterka, M., Jernvall, J., Martin, G. R. Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling. Dev. Cell 11: 181-190, 2006.
3. Miraoui, H., Dwyer, A. A., Sykiotis, G. P., Plummer, L., Chung, W., Feng, B., Beenken, A., Clarke, J., Pers, T. H., Dworzynski, P., Keefe, K., Niedziela, M., and 17 others. Mutations in FGF17, IL17RD, DUPS6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. Am. J. Hum. Genet. 92: 725-743, 2013.

Other Notes

Small volumes of anti-SPRY4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SPRY4 purchase

MBS1753106 is an antibody targeting SPRY4. Also known as Anti-Sprouty 4/Spry-4/SPRY4 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SPRY4. It may not necessarily be applicable to this product.

NCBI GI #
188595697
NCBI GeneID
81848
NCBI Accession #
NP_001120968.1
UniProt Primary Accession #
Q9C004
UniProt Related Accession #
Q9C004
GenBank Nucleotide #
NP_001120968.1
NCBI Official Full Name
protein sprouty homolog 4 isoform 2
NCBI Official Synonym Full Names
sprouty RTK signaling antagonist 4
NCBI Official Symbol
SPRY4
NCBI Official Synonym Symbols
HH17
UniProt Protein Name
Protein sprouty homolog 4
Protein Family
Protein sprouty
UniProt Gene Name
SPRY4
UniProt Synonym Gene Names
Spry-4
UniProt Entry Name
SPY4_HUMAN
NCBI Protein Information
protein sprouty homolog 4

NCBI Summary for SPRY4

This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014]
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UniProt Comments for SPRY4

SPRY4: Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1. Belongs to the sprouty family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Inhibitor

Chromosomal Location of Human Ortholog: 5q31.3

Cellular Component: Golgi apparatus; focal adhesion; cytoplasm

Molecular Function: protein binding

Biological Process: negative regulation of MAP kinase activity; multicellular organismal development

Disease: Hypogonadotropic Hypogonadism 17 With Or Without Anosmia
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Research Articles on SPRY4

1. The authors demonstrated that Spry4 functions as tumor-suppressing protein in cancerogenesis of brain malignancies.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SPRY4 antibody

 Reference Product  PubMed Publications
 DUSP6 antibody  >6 publications with SPRY4 and DUSP6
 CBL antibody  >3 publications with SPRY4 and CBL
 RAF1 antibody  >2 publications with SPRY4 and RAF1
 IL17RD antibody  >2 publications with SPRY4 and IL17RD
 TESK1 antibody  >2 publications with SPRY4 and TESK1
 FRS2 antibody  >1 publications with SPRY4 and FRS2

Pathways associated with anti-SPRY4 antibody

 Products by Pathway  Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with anti-SPRY4 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >6 publications with SPRY4 and Disease Models, Animal
 Lung Diseases Antibodies  >3 publications with SPRY4 and Lung Diseases
 Lung Neoplasms Antibodies  >2 publications with SPRY4 and Lung Neoplasms
 Immune System Diseases Antibodies  >2 publications with SPRY4 and Immune System Diseases
 Skin Neoplasms Antibodies  >2 publications with SPRY4 and Skin Neoplasms
 Urogenital Abnormalities Antibodies  >2 publications with SPRY4 and Urogenital Abnormalities
 Ovarian Diseases Antibodies  >2 publications with SPRY4 and Ovarian Diseases
 Precancerous Conditions Antibodies  >1 publications with SPRY4 and Precancerous Conditions
 Atherosclerosis Antibodies  >1 publications with SPRY4 and Atherosclerosis
 Fetal Death Antibodies  >1 publications with SPRY4 and Fetal Death

Organs/Tissues associated with anti-SPRY4 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >31 publications with SPRY4 and Embryonic Tissue
 Lung Antibodies  >13 publications with SPRY4 and Lung
 Blood Antibodies  >12 publications with SPRY4 and Blood
 Brain Antibodies  >11 publications with SPRY4 and Brain
 Mouth Antibodies  >9 publications with SPRY4 and Mouth
 Bone Antibodies  >9 publications with SPRY4 and Bone
 Skin Antibodies  >5 publications with SPRY4 and Skin
 Ovary Antibodies  >4 publications with SPRY4 and Ovary
 Testis Antibodies  >4 publications with SPRY4 and Testis
 Muscle Antibodies  >4 publications with SPRY4 and Muscle
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