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Kk Gamma (IKBKG) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175365

Description: Rabbit IgG polyclonal antibody for NF-kappa-B essential modulator(IKBKG) detection. Tested with WB in Mouse.Background: IKBKG(Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase of, gamma) is also known as NEMO. The IKK complex… More details

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Product Overview

Online Datasheet in PDF
Product Name
KK gamma (IKBKG), Polyclonal Antibody
Full Product Name
Anti-KK gamma antibody
Product Gene Name
anti-IKBKG antibody
Product Synonym Names
NF-kappa-B essential modulator(NEMO); inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; IkB kinase associated protein 1 antibody; IkB kinase subunit gamma antibody; Inhibitor of nuclear factor kappa B kinase subunit gamma antibody; AMCBX1 antibody; FIP 3 antibody; FIP-3 antibody; FIP3 antibody; Fip3p antibody; I kappa B kinase gamma antibody; I-kappa-B kinase subunit gamma antibody; IkB kinase associated protein 1 antibody; IkB kinase gamma subunit antibody; IkB kinase subunit gamma antibody; IkB kinase-associated protein 1 antibody; IKBKG antibody; IKK-gamma antibody; IKKAP 1 antibody; IKKAP1 antibody; IKKG antibody; Incontinentia pigmenti antibody; Inhibitor of kappa light polypeptide gene enhancer in B cells kinase gamma antibody; Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase gamma antibody; Inhibitor of nuclear factor kappa B kinase gamma subunit antibody; Inhibitor of nuclear factor kappa B kinase subunit gamma antibody; Inhibitor of nuclear factor kappa-B kinase subunit gamma antibody; IP 1 antibody; IP 2 antibody; IP antibody; IP1 antibody; IP2 antibody; IPD2 antibody; NEMO antibody; NEMO_HUMAN antibody; NF kappa B essential modifier antibody; NF kappa B essential modulator antibody; NF kappaB essential modifier antibody; NF kappaB essential modulator antibody; NF-kappa-B essential modifier antibody; NF-kappa-B essential modulator antibody; NFkappaB essential modulator antibody; ZC2HC9 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
47,972 Da
3D Structure
ModBase 3D Structure for O88522
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of mouse KK gamma (1-15aa MNKHPWKNQLSEMVQ), different from the relative rat sequence by three amino acids.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-IKBKG antibody
Western Blot (WB)

Western Blot (WB) of anti-IKBKG antibody

Anti-IKK gamma antibody, MBS175365, Western blotting
Lane 1: Mouse Liver Tissue Lysate
Lane 2: Mouse Brain Tissue Lysate
Lane 3: Mouse Ovary Tissue Lysate
Rabbit Anti-IKBKG Polyclonal Antibody – Cat# MBS175365

Other Notes

Small volumes of anti-IKBKG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IKBKG purchase

MBS175365 is an antibody targeting IKBKG. Also known as Anti-KK gamma antibody. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IKBKG. It may not necessarily be applicable to this product.

NCBI GI #
341941165
NCBI GeneID
16151
NCBI Accession #
O88522.2
UniProt Primary Accession #
O88522
UniProt Secondary Accession #
Q924H4
UniProt Related Accession #
O88522
NCBI Official Full Name
NF-kappa-B essential modulator
NCBI Official Synonym Full Names
inhibitor of kappaB kinase gamma
NCBI Official Symbol
Ikbkg
NCBI Official Synonym Symbols
NEMO; IKK[g]; AI848108; AI851264; AW124339; 1110037D23Rik
UniProt Protein Name
NF-kappa-B essential modulator
UniProt Synonym Protein Names
IkB kinase-associated protein 1; IKKAP1; mFIP-3; Inhibitor of nuclear factor kappa-B kinase subunit gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma; NF-kappa-B essential modifier
Protein Family
Ketoisovalerate oxidoreductase
UniProt Gene Name
Ikbkg
UniProt Synonym Gene Names
Nemo; NEMO; IKKAP1; mFIP-3; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma
UniProt Entry Name
NEMO_MOUSE
NCBI Protein Information
NF-kappa-B essential modulator; IKKG; IKKAP1; mFIP-3; IKK-gamma; ikB kinase subunit gamma; NF-kappa-B essential modifier; I-kappa-B kinase subunit gamma; ikB kinase-associated protein 1; inhibitor of nuclear factor kappa-B kinase subunit gamma; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

UniProt Comments for IKBKG

IKKG: a regulatory subunit of the IKK-signalosome complex. Interacts preferentially with IKK-beta but also able to interact with IKK-alpha, IKAP, TAX, RIP and MAP3K14/NIK. Defects are the cause of familial incontinentia pigmenti type II (IP2).

Protein type: Adaptor/scaffold; Protein kinase, regulatory subunit

Cellular Component: spindle pole; cytoplasm; IkappaB kinase complex; intracellular; cytosol; nucleus; ubiquitin ligase complex

Molecular Function: protein domain specific binding; peroxisome proliferator activated receptor binding; protein binding; protein homodimerization activity; protein heterodimerization activity; metal ion binding; ubiquitin protein ligase binding

Biological Process: establishment of vesicle localization; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of transcription, DNA-dependent; B cell homeostasis; transcription, DNA-dependent; activation of NF-kappaB-inducing kinase; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; activation of NF-kappaB transcription factor
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Research Articles on IKBKG

1. NEMO ubiquitination is required for optimal innate immune signaling responses. These findings suggest that NEMO ubiquitination is crucial for NF-kappaB activity in response to innate immune agonists.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IKBKG antibody

 Reference Product  PubMed Publications
 Ikbkb antibody  >290 publications with IKBKG and Ikbkb
 Traf6 antibody  >16 publications with IKBKG and Traf6
 Chuk antibody  >15 publications with IKBKG and Chuk
 Bcl10 antibody  >6 publications with IKBKG and Bcl10
 Cyld antibody  >6 publications with IKBKG and Cyld
 Tlr4 antibody  >5 publications with IKBKG and Tlr4
 Map3k7 antibody  >2 publications with IKBKG and Map3k7
 Nfkbia antibody  >1 publications with IKBKG and Nfkbia
 Ubc antibody  >1 publications with IKBKG and Ubc

Pathways associated with anti-IKBKG antibody

 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram

Diseases associated with anti-IKBKG antibody

 Disease Name  Pubmed Publications
 Incontinentia Pigmenti Antibodies  >80 publications with IKBKG and Incontinentia Pigmenti
 Necrosis Antibodies  >65 publications with IKBKG and Necrosis
 Inflammation Antibodies  >40 publications with IKBKG and Inflammation
 Nervous System Diseases Antibodies  >19 publications with IKBKG and Nervous System Diseases
 Liver Diseases Antibodies  >6 publications with IKBKG and Liver Diseases
 Adenocarcinoma Antibodies  >6 publications with IKBKG and Adenocarcinoma
 Disease Models, Animal Antibodies  >6 publications with IKBKG and Disease Models, Animal
 Liver Neoplasms Antibodies  >5 publications with IKBKG and Liver Neoplasms
 Breast Neoplasms Antibodies  >5 publications with IKBKG and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >4 publications with IKBKG and Cardiovascular Diseases

Organs/Tissues associated with anti-IKBKG antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >50 publications with IKBKG and Skin
 Blood Antibodies  >49 publications with IKBKG and Blood
 Brain Antibodies  >15 publications with IKBKG and Brain
 Bone Antibodies  >10 publications with IKBKG and Bone
 Liver Antibodies  >8 publications with IKBKG and Liver
 Bone Marrow Antibodies  >7 publications with IKBKG and Bone Marrow
 Kidney Antibodies  >7 publications with IKBKG and Kidney
 Eye Antibodies  >6 publications with IKBKG and Eye
 Lung Antibodies  >3 publications with IKBKG and Lung
 Muscle Antibodies  >3 publications with IKBKG and Muscle
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