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AQP3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9601395

Function: Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin… More details

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Product Overview

Online Datasheet in PDF
Product Name
AQP3, Polyclonal Antibody
Full Product Name
AQP3 Antibody
Product Gene Name
anti-AQP3 antibody
Product Synonym Names
AQP 3; AQP-3; Aqp3; AQP3_HUMAN; Aquaglyceroporin-3; Aquaporin 3 (GIL blood group); Aquaporin 3 (Gill blood group); Aquaporin-3; Aquaporin3; GIL; Gill blood group
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
AQP3 antibody detects endogenous levels of total AQP3
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
AQP3 peptide (MBS9616927) is used for blocking the activity of AQP3 antibody (MBS9601395)
Molecular Weight
Observed: 31 kDa
Predicted: 32 kDa
3D Structure
ModBase 3D Structure for Q92482
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human AQP3
Subcellular Location
Basolateral Cell Membrane. In collecting ducts of kidney.
Tissue Specificity
Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level.
Predicted Cross Reactivity
Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus
Similarity
Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Xenopus (100%)
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-AQP3 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-AQP3 antibody
WB: 1:500
IHC: 1:50-1:200

Immunohistochemistry (IHC) of anti-AQP3 antibody

MBS9601395 at 1/100 staining Human liver cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Rabbit Anti-AQP3 Polyclonal Antibody – Cat# MBS9601395

Immunohistochemistry (IHC) of anti-AQP3 antibody

MBS9601395 at 1/100 staining Human lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Rabbit Anti-AQP3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9601395

Western Blot (WB) of anti-AQP3 antibody

Western blot analysis of extracts from Jurkat cells, using AQP3 antibody., The lane on the left is treated with the antigen-specific peptide.
Rabbit Anti-AQP3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9601395

Other Notes

Small volumes of anti-AQP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AQP3 purchase

MBS9601395 is an antibody targeting AQP3. Also known as AQP3 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AQP3. It may not necessarily be applicable to this product.

NCBI GI #
970259826
NCBI GeneID
360
NCBI Accession #
NP_001305073.1
UniProt Primary Accession #
Q92482
UniProt Secondary Accession #
O00108; Q6FGT2; Q6FGW6; A8K843; B2RE16; D3DRL3
UniProt Related Accession #
Q92482
GenBank Nucleotide #
NM_001318144.1
NCBI Official Full Name
aquaporin-3 isoform 2
NCBI Official Synonym Full Names
aquaporin 3 (Gill blood group)
NCBI Official Symbol
AQP3
NCBI Official Synonym Symbols
GIL; AQP-3
UniProt Protein Name
Aquaporin-3
UniProt Synonym Protein Names
Aquaglyceroporin-3
Protein Family
Aquaporin
UniProt Gene Name
AQP3
UniProt Synonym Gene Names
AQP-3
NCBI Protein Information
aquaporin-3

NCBI Summary for AQP3

This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
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UniProt Comments for AQP3

Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism ().
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Research Articles on AQP3

1. TFF peptides promptly produced at sites of injury increase AQP levels, most notably AQP3, thereby enhancing the cells' ability to rapidly change their shape as part of the restitutive process. TFF peptides also require functioning AQP3 channels to induce cell migration.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AQP3 antibody

 Reference Product  PubMed Publications
 AQP2 antibody  >238 publications with AQP3 and AQP2
 AVP antibody  >26 publications with AQP3 and AVP
 KLF4 antibody  >2 publications with AQP3 and KLF4
 SLC14A2 antibody  >1 publications with AQP3 and SLC14A2

Pathways associated with anti-AQP3 antibody

 Products by Pathway  Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Passive Transport By Aquaporins Pathway antibodies  Passive Transport By Aquaporins Pathway Diagram
 Preimplantation Embryo Pathway antibodies  Preimplantation Embryo Pathway Diagram
 Stabilization And Expansion Of The E-cadherin Adherens Junction Pathway antibodies  Stabilization And Expansion Of The E-cadherin Adherens Junction Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Vasopressin Regulates Renal Water Homeostasis Via Aquaporins Pathway antibodies  Vasopressin Regulates Renal Water Homeostasis Via Aquaporins Pathway Diagram
 Vasopressin-regulated Water Reabsorption Pathway antibodies  Vasopressin-regulated Water Reabsorption Pathway Diagram
 Vasopressin-regulated Water Reabsorption Pathway antibodies  Vasopressin-regulated Water Reabsorption Pathway Diagram

Diseases associated with anti-AQP3 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >59 publications with AQP3 and Kidney Diseases
 Disease Models, Animal Antibodies  >52 publications with AQP3 and Disease Models, Animal
 Edema Antibodies  >29 publications with AQP3 and Edema
 Inflammation Antibodies  >26 publications with AQP3 and Inflammation
 Cardiovascular Diseases Antibodies  >24 publications with AQP3 and Cardiovascular Diseases
 Liver Diseases Antibodies  >17 publications with AQP3 and Liver Diseases
 Nervous System Diseases Antibodies  >15 publications with AQP3 and Nervous System Diseases
 Diarrhea Antibodies  >15 publications with AQP3 and Diarrhea
 Lung Diseases Antibodies  >15 publications with AQP3 and Lung Diseases
 Carcinoma, Squamous Cell Antibodies  >15 publications with AQP3 and Carcinoma, Squamous Cell

Organs/Tissues associated with anti-AQP3 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >241 publications with AQP3 and Kidney
 Blood Antibodies  >143 publications with AQP3 and Blood
 Skin Antibodies  >96 publications with AQP3 and Skin
 Lung Antibodies  >63 publications with AQP3 and Lung
 Liver Antibodies  >57 publications with AQP3 and Liver
 Intestine Antibodies  >54 publications with AQP3 and Intestine
 Brain Antibodies  >50 publications with AQP3 and Brain
 Eye Antibodies  >38 publications with AQP3 and Eye
 Heart Antibodies  >31 publications with AQP3 and Heart
 Salivary Gland Antibodies  >29 publications with AQP3 and Salivary Gland
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