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CAMKK1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175564

Description: Rabbit IgG polyclonal antibody for Calcium/calmodulin-dependent protein kinase kinase 1(CAMKK1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.Background: CAMKK1, Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in… More details

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Product Overview

Online Datasheet in PDF
Product Name
CaMKK (CAMKK1), Polyclonal Antibody
Full Product Name
Anti-CaMKK antibody
Product Gene Name
anti-CAMKK1 antibody
Product Synonym Names
Calcium/calmodulin-dependent protein kinase kinase 1(CaM-KK 1/CaM-kinase kinase 1/CaMKK 1); calcium/calmodulin-dependent protein kinase kinase 1, alpha; Ca2+/calmodulin-dependent protein kinase kinase alpha antibody; Calcium/calmodulin dependent protein kinase kinase antibody; Calcium/calmodulin dependent protein kinase kinase 1 alpha antibody; Calcium/calmodulin dependent protein kinase kinase 1 antibody; Calcium/calmodulin dependent protein kinase kinase alpha antibody; Calcium/calmodulin-dependent protein kinase kinase 1 antibody; Calcium/calmodulin-dependent protein kinase kinase alpha antibody; CaM kinase kinase alpha antibody; CaM-kinase IV kinase antibody; CaM-kinase kinase 1 antibody; CaM-kinase kinase alpha antibody; CaM-KK 1 antibody; CaM-KK alpha antibody; CaMKK 1 antibody; CaMKK alpha antibody; CAMKK alpha protein antibody; CaMKK antibody; CAMKK1 antibody; CAMKKA antibody; DKFZp761M0423 antibody; KKCC1_HUMAN antibody; MGC34095 antibody; OTTMUSP00000006419 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
55,838 Da
3D Structure
ModBase 3D Structure for Q8VBY2
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of mouse CaMKK (10-31aa QDPRAELVDRVAAINVAHLEEA), different from the related human sequence by three amino acids, and from the related rat sequence by two amino acids.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CAMKK1 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Western Blot (WB) of anti-CAMKK1 antibody

Anti-CaMKK antibody, MBS175564, Western blotting
Lane 1: Rat Brain Tissue Lysate
Lane 2: Rat Brain Tissue Lysate
Lane 3: Mouse Brain Tissue Lysate
Lane 4: Mouse Brain Tissue Lysate
Rabbit Anti-CAMKK1 Polyclonal Antibody – Cat# MBS175564

Immunohistochemistry (IHC) of anti-CAMKK1 antibody

Anti-CaMKK antibody, MBS175564, IHC(P)
IHC(P): Rat Brain Tissue
Rabbit Anti-CAMKK1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS175564

Other Notes

Small volumes of anti-CAMKK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CAMKK1 purchase

MBS175564 is an antibody targeting CAMKK1. Also known as Anti-CaMKK antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CAMKK1. It may not necessarily be applicable to this product.

NCBI GI #
56404639
NCBI GeneID
55984
NCBI Accession #
Q8VBY2.1
UniProt Primary Accession #
Q8VBY2
UniProt Secondary Accession #
Q9R054
UniProt Related Accession #
Q8VBY2
NCBI Official Full Name
Calcium/calmodulin-dependent protein kinase kinase 1
NCBI Official Synonym Full Names
calcium/calmodulin-dependent protein kinase kinase 1, alpha
NCBI Official Symbol
Camkk1
NCBI Official Synonym Symbols
Camkk; AI846603; CaMKKalpha
UniProt Protein Name
Calcium/calmodulin-dependent protein kinase kinase 1
UniProt Synonym Protein Names
CaM-kinase IV kinase; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-KK alpha; CaM-kinase kinase alpha; CaMKK alpha
Protein Family
Calcium/calmodulin-dependent protein kinase
UniProt Gene Name
Camkk1
UniProt Synonym Gene Names
Camkk; CaM-KK 1; CaM-kinase kinase 1; CaMKK 1; CaM-KK alpha; CaM-kinase kinase alpha; CaMKK alpha
UniProt Entry Name
KKCC1_MOUSE
NCBI Protein Information
calcium/calmodulin-dependent protein kinase kinase 1; caMKK 1; caM-KK 1; caMKK alpha; caM-KK alpha; caM-kinase kinase 1; caM-kinase IV kinase; caM-kinase kinase alpha; calcium calmodulin dependent protein kinase kinase alpha; calcium/calmodulin-dependent protein kinase kinase alpha

UniProt Comments for CAMKK1

CAMKK1: a calcium/calmodulin-dependent S/T protein kinase of the CAMKK family. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. 2 isoforms of the human protein are produced by alternative splicing. The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition. Binding of calmodulin may releave intrasteric autoinhibition. May be regulated through phosphorylation by CAMK1 and CAMK4. Appears to be autophosphorylated in a Ca2+/calmodulin-dependent manner. Phosphorylation of Ser-458 is blocked upon binding to Ca2+/calmodulin.

Protein type: Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.17; Kinase, protein; Other group; CAMKK family; Meta subfamily

Cellular Component: cytoplasm; nucleus

Molecular Function: transferase activity; calmodulin binding; protein serine/threonine kinase activity; calmodulin-dependent protein kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity

Biological Process: positive regulation of protein kinase activity; activation of protein kinase activity; protein amino acid phosphorylation; phosphorylation
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Research Articles on CAMKK1

1. caCaMKKalpha stimulates glucose uptake additively with insulin, and in insulin-resistant muscle, and alters the phosphorylation of TBC1D1/TBC1D4.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CAMKK1 antibody

 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 CREB Phosphorylation Through The Activation Of CaMKK Pathway antibodies  CREB Phosphorylation Through The Activation Of CaMKK Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram

Diseases associated with anti-CAMKK1 antibody

 Disease Name  Pubmed Publications
 Memory Disorders Antibodies  >1 publications with CAMKK1 and Memory Disorders
 Inflammation Antibodies  >1 publications with CAMKK1 and Inflammation
 Neurobehavioral Manifestations Antibodies  >1 publications with CAMKK1 and Neurobehavioral Manifestations
 Nervous System Diseases Antibodies  >1 publications with CAMKK1 and Nervous System Diseases

Organs/Tissues associated with anti-CAMKK1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with CAMKK1 and Brain
 Embryonic Tissue Antibodies  >1 publications with CAMKK1 and Embryonic Tissue
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