Human TPM4 cDNA Clone Expression Plasmid – Cat# MBS1273479

TPM4 cDNA Clone – Tropomyosin 4 (Human)

Name: TPM4 cDNA Clone; Tropomyosin 4; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1273479
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1273479

MBS1273479 is a cDNA clone targeting TPM4. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TPM4, cDNA Clone

Full Product Name

TPM4 cDNA Clone

Product Gene Name

TPM4 cdna clone

Sequence

atggccggcc tcaactccct ggaggcggtg aaacgcaaga tccaggccct gcagcagcag gcggacgagg cggaagaccg cgcgcagggc ctgcagcggg agctggacgg cgagcgcgag cggcgcgaga aagctgaagg tgatgtggcc gccctcaacc gacgcatcca gctcgttgag gaggagttgg acagggctca ggaacgactg gccacggccc tgcagaagct ggaggaggca gaaaaagctg cagatgagag tgagagagga atgaaggtga tagaaaaccg ggccatgaag gatgaggaga agatggagat tcaggagatg cagctcaaag aggccaagca cattgcggaa gaggctgacc gcaaatacga ggaggtagct cgtaagctgg tcatcctgga gggtgagctg gagagggcag aggagcgtgc ggaggtgtct gaactaaaat gtggtgacct ggaagaagaa ctcaagaatg ttactaacaa tctgaaatct ctggaggctg catctgaaaa gtattctgaa aaggaggaca aatatgaaga agaaattaaa cttctgtctg acaaactgaa agaggctgag acccgtgctg aatttgcaga gagaacggtt gcaaaactgg aaaagacaat tgatgacctg gaagagaaac ttgcccaggc caaagaagag aacgtgggct tacatcagac actggatcag acactaaacg aacttaactg tatataa

Molecular Weight

32,723 Da

OMIM

600317

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TPM4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TPM4. It may not necessarily be applicable to this product.

NCBI GI #

22902217

NCBI GeneID

7171

NCBI Accession #

BC037576

UniProt Secondary Accession #

P07226; Q15659; Q5U0D9; Q9BU85; Q9H8Q3; Q9UCS1; Q9UCS2; Q9UCS3; Q9UCS4

UniProt Related Accession #

P67936

NCBI Official Full Name

Homo sapiens tropomyosin 4, mRNA

NCBI Official Synonym Full Names

tropomyosin 4

NCBI Official Symbol

TPM4

NCBI Official Synonym Symbols

HEL-S-108

UniProt Protein Name

Tropomyosin alpha-4 chain

UniProt Synonym Protein Names

TM30p1; Tropomyosin-4

Protein Family

Tropomyosin

UniProt Gene Name

TPM4

UniProt Entry Name

TPM4_HUMAN

NCBI Protein Information

tropomyosin alpha-4 chain

NCBI Summary for TPM4

This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

UniProt Comments for TPM4

TPM4: a cytoskeletal protein that binds to actin filaments in muscle and nonmuscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments and endocytosis.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: cytoskeleton; cytosol; focal adhesion; membrane; muscle thin filament tropomyosin; stress fiber

Molecular Function: protein binding; structural constituent of muscle

Biological Process: cell motility; muscle contraction; muscle filament sliding; osteoblast differentiation

Research Articles on TPM4

1. In addition to CLIC1 and TPM1, which were the proteins initially discovered in a xenograft mouse model, CLIC4, TPM2, TPM3, and TPM4 were present in ovarian cancer patient sera at significantly elevated levels compared with controls.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with TPM4 cdna clone

Products by Pathway	Pathway Diagram
Cardiac Muscle Contraction Pathway antibodies	Cardiac Muscle Contraction Pathway Diagram
Cardiac Muscle Contraction Pathway antibodies	Cardiac Muscle Contraction Pathway Diagram
Dilated Cardiomyopathy Pathway antibodies	Dilated Cardiomyopathy Pathway Diagram
Dilated Cardiomyopathy Pathway antibodies	Dilated Cardiomyopathy Pathway Diagram
Hypertrophic Cardiomyopathy (HCM) Pathway antibodies	Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
Hypertrophic Cardiomyopathy (HCM) Pathway antibodies	Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
Muscle Contraction Pathway antibodies	Muscle Contraction Pathway Diagram
Smooth Muscle Contraction Pathway antibodies	Smooth Muscle Contraction Pathway Diagram
Striated Muscle Contraction Pathway antibodies	Striated Muscle Contraction Pathway Diagram
Striated Muscle Contraction Pathway antibodies	Striated Muscle Contraction Pathway Diagram

Diseases associated with TPM4 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>18 publications with TPM4 and Neoplasms
Esophageal Neoplasms Antibodies	>4 publications with TPM4 and Esophageal Neoplasms
Breast Neoplasms Antibodies	>3 publications with TPM4 and Breast Neoplasms
Inflammation Antibodies	>3 publications with TPM4 and Inflammation
Cardiovascular Diseases Antibodies	>2 publications with TPM4 and Cardiovascular Diseases
Disease Models, Animal Antibodies	>2 publications with TPM4 and Disease Models, Animal
Atherosclerosis Antibodies	>1 publications with TPM4 and Atherosclerosis
Nervous System Diseases Antibodies	>1 publications with TPM4 and Nervous System Diseases
Neoplasms, Experimental Antibodies	>1 publications with TPM4 and Neoplasms, Experimental
Fibrosis Antibodies	>1 publications with TPM4 and Fibrosis

Organs/Tissues associated with TPM4 cdna clone

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>14 publications with TPM4 and Muscle
Heart Antibodies	>8 publications with TPM4 and Heart
Blood Antibodies	>5 publications with TPM4 and Blood
Lung Antibodies	>5 publications with TPM4 and Lung
Embryonic Tissue Antibodies	>4 publications with TPM4 and Embryonic Tissue
Vascular Antibodies	>3 publications with TPM4 and Vascular
Esophagus Antibodies	>2 publications with TPM4 and Esophagus
Placenta Antibodies	>1 publications with TPM4 and Placenta
Liver Antibodies	>1 publications with TPM4 and Liver
Lymph Node Antibodies	>1 publications with TPM4 and Lymph Node