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MCM2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175619

Description: Rabbit IgG polyclonal antibody for DNA replication licensing factor MCM2(MCM2) detection. Tested with WB, IHC-P, ICC in Mouse, Rat.Background: MCM2(MINICHROMOSOME MAINTENANCE, S. CEREVISIAE, HOMOLOG OF, 2),also known as MITOTIN, CDCL1 or BM28, is… More details

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Product Overview

Online Datasheet in PDF
Product Name
MCM2, Polyclonal Antibody
Full Product Name
Anti-MCM2 antibody
Product Gene Name
anti-MCM2 antibody
Product Synonym Names
DNA replication licensing factor MCM2; minichromosome maintenance complex component 2; BM28 antibody; CCNL 1 antibody; CCNL1 antibody; CDC like 1 antibody; CDC like-1 antibody; cdc19 antibody; CDCL 1 antibody; CDCL1 antibody; Cell devision cycle like 1 antibody; Cyclin like 1 antibody; cyclin like-1 antibody; D3S3194 antibody; DNA replication licensing factor MCM2 antibody; KIAA0030 antibody; MCM 2 antibody; MCM2 antibody; MCM2 minichromosome maintenance deficient 2 mitotin antibody; MCM2 minichromosome maintenance deficient 2 mitotin(S. cerevisiae) antibody; MCM2 minichromosome maintenance deficient 2, mitotin antibody; MCM2_HUMAN antibody; MGC10606 antibody; Minichromosome maintenance complex component 2 antibody; Minichromosome maintenance deficient 2(mitotin) antibody; Minichromosome maintenance deficient 2 mitotin antibody; Minichromosome maintenance protein 2 antibody; Minichromosome maintenance protein 2 homolog antibody; Mitotin antibody; Nuclear protein BM28 antibody; OTTHUMP00000216047 antibody; OTTHUMP00000216050 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
102,078 Da
3D Structure
ModBase 3D Structure for P97310
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of mouse MCM2 (884-904aa DLFKFNKFSRDLKRKLILQQF), different from the related rat sequence by one amino acid.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-MCM2 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

Immunohistochemistry (IHC) of anti-MCM2 antibody

Anti-MCM2 antibody, MBS175619, IHC(P)
IHC(P): Rat Intestinal Lymphocyte Tissue
Rabbit Anti-MCM2 Polyclonal Antibody – Cat# MBS175619

Immunohistochemistry (IHC) of anti-MCM2 antibody

Anti-MCM2 antibody, MBS175619, IHC(P)
IHC(P): Mouse Intestine Tissue
Rabbit Anti-MCM2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS175619

Western Blot (WB) of anti-MCM2 antibody

Anti-MCM2 antibody, MBS175619, Western blotting
All lanes: Anti MCM2 (MBS175619) at 0.5ug/ml
Lane 1: Rat Testis Tissue Lysate at 50ug
Lane 2: Rat Kidney Tissue Lysate at 50ug
Lane 3: Mouse Intestine Tissue Lysate at 50ug
Lane 4: Mouse Testis Tissue Lysate at 50ug
Lane 5: Mouse Ovary Tissue Lysate at 50ug
Lane 6: Mouse Kidney Tissue Lysate at 50ug
Predicted bind size: 102KD
Observed bind size: 102KD
Rabbit Anti-MCM2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS175619

Immunocytochemistry (ICC) of anti-MCM2 antibody

Anti-MCM2 antibody, MBS175619, ICC
ICC: HEPA Cell
Rabbit Anti-MCM2 Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS175619

Immunocytochemistry (ICC) of anti-MCM2 antibody

Anti-MCM2 antibody, MBS175619, ICC
ICC: NIH3T3 Cell
Rabbit Anti-MCM2 Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS175619

Other Notes

Small volumes of anti-MCM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MCM2 purchase

MBS175619 is an antibody targeting MCM2. Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MCM2. It may not necessarily be applicable to this product.

NCBI GI #
46397854
NCBI GeneID
17216
NCBI Accession #
P97310.3
UniProt Primary Accession #
P97310
UniProt Secondary Accession #
O08971; O89057; Q8C2R0
UniProt Related Accession #
P97310
NCBI Official Full Name
DNA replication licensing factor MCM2
NCBI Official Synonym Full Names
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
NCBI Official Symbol
Mcm2
NCBI Official Synonym Symbols
BM28; CDCL1; Mcmd2; AA959861; AW476101; mKIAA0030
UniProt Protein Name
DNA replication licensing factor MCM2
UniProt Synonym Protein Names
Minichromosome maintenance protein 2 homolog; Nuclear protein BM28
Protein Family
DNA replication licensing factor
UniProt Gene Name
Mcm2
UniProt Synonym Gene Names
Bm28; Cdcl1; Kiaa0030; Mcmd2
UniProt Entry Name
MCM2_MOUSE
NCBI Protein Information
DNA replication licensing factor MCM2; nuclear protein BM28; mini chromosome maintenance deficient 2; minichromosome maintenance protein 2 homolog

UniProt Comments for MCM2

MCM2: a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division.

Protein type: EC 3.6.4.12; DNA-binding

Cellular Component: nucleoplasm; microtubule cytoskeleton; MCM complex; cytoplasm; chromatin; nuclear origin of replication recognition complex; nucleus

Molecular Function: DNA helicase activity; DNA binding; hydrolase activity; histone binding; metal ion binding; nucleotide binding; DNA replication origin binding; helicase activity; ATP binding

Biological Process: DNA unwinding during replication; nucleosome assembly; DNA replication initiation; DNA replication; cell cycle
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Research Articles on MCM2

1. Hematopoietic cells originally express higher levels MCM 2 protein and undergo more frequent apoptosis following doxorubicin-induced DNA-damage in the presence of the FLV envelope protein gp70.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MCM2 antibody

 Products by Pathway  Pathway Diagram
 Activation Of ATR In Response To Replication Stress Pathway antibodies  Activation Of ATR In Response To Replication Stress Pathway Diagram
 Activation Of The Pre-replicative Complex Pathway antibodies  Activation Of The Pre-replicative Complex Pathway Diagram
 Assembly Of The Pre-replicative Complex Pathway antibodies  Assembly Of The Pre-replicative Complex Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Signaling Pathway antibodies  Cell Cycle Signaling Pathway Diagram

Diseases associated with anti-MCM2 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >54 publications with MCM2 and Adenocarcinoma
 Nervous System Diseases Antibodies  >21 publications with MCM2 and Nervous System Diseases
 Precancerous Conditions Antibodies  >20 publications with MCM2 and Precancerous Conditions
 Cell Transformation, Neoplastic Antibodies  >18 publications with MCM2 and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >17 publications with MCM2 and Breast Neoplasms
 Brain Diseases Antibodies  >17 publications with MCM2 and Brain Diseases
 Neoplasms, Experimental Antibodies  >14 publications with MCM2 and Neoplasms, Experimental
 Liver Diseases Antibodies  >13 publications with MCM2 and Liver Diseases
 Hyperplasia Antibodies  >11 publications with MCM2 and Hyperplasia
 Neoplasm Metastasis Antibodies  >11 publications with MCM2 and Neoplasm Metastasis

Organs/Tissues associated with anti-MCM2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >31 publications with MCM2 and Brain
 Blood Antibodies  >24 publications with MCM2 and Blood
 Lung Antibodies  >23 publications with MCM2 and Lung
 Lymph Node Antibodies  >22 publications with MCM2 and Lymph Node
 Bone Antibodies  >16 publications with MCM2 and Bone
 Skin Antibodies  >11 publications with MCM2 and Skin
 Bladder Antibodies  >11 publications with MCM2 and Bladder
 Intestine Antibodies  >11 publications with MCM2 and Intestine
 Prostate Antibodies  >10 publications with MCM2 and Prostate
 Uterus Antibodies  >10 publications with MCM2 and Uterus
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