Rabbit Anti-EIF2AK4 Polyclonal Antibody – Cat# MBS176330

Anti-GCN2 antibody, MBS176330, Western blotting
Recombinant Protein Detection Source: E.coli derived -recombinant Mouse EIF2AK4, 35.3KD(162aa tag+ E801-R954)
Lane 1: Recombinant Mouse EIF2AK4 Protein 10ng
Lane 2: Recombinant Mouse EIF2AK4 Protein 5ng
Lane 3: Recombinant Mouse EIF2AK4 Protein 2.5ng
Lane 4: Recombinant Mouse EIF2AK4 Protein 1.25ng

EIF2AK4 Antibody – Rabbit Polyclonal

Name: EIF2AK4 Antibody; Polyclonal; Rabbit; Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS176330
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS176330

Description: Rabbit IgG polyclonal antibody for Eukaryotic translation initiation factor 2-alpha kinase 4(EIF2AK4) detection. Tested with WB in Mouse, Rat.Background: EIF2AK4(Eukaryotic Translation Initiation Factor 2-Alpha Kinase 4), also called GCN2, is an… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GCN2 (EIF2AK4), Polyclonal Antibody

Full Product Name

Anti-GCN2 antibody

Product Gene Name

anti-EIF2AK4 antibody

Product Synonym Names

Eukaryotic translation initiation factor 2-alpha kinase 4; eukaryotic translation initiation factor 2 alpha kinase 4; E2AK4_HUMAN antibody; Eif2ak4 antibody; Eukaryotic Translation Initiation Factor 2 alpha kinase 4 antibody; Eukaryotic translation initiation factor 2-alpha kinase 4 antibody; GCN2 antibody; GCN2 eIF2alpha kinase antibody; GCN2 like protein antibody; GCN2-like protein antibody; KIAA1338 antibody; MGCN2 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Mouse, Rat

Form/Format

Lyophilized

Purity/Purification

Immunogen affinity purified.

Preparation and Storage

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

59,991 Da

3D Structure

ModBase 3D Structure for Q9QZ05

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of mouse GCN2 (868-886aa ATDHLAFTAEGKQDDQAGD), different from the related rat sequence by one amino acid.

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-EIF2AK4 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-EIF2AK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EIF2AK4 purchase

MBS176330 is an antibody targeting EIF2AK4. Also known as Anti-GCN2 antibody. Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EIF2AK4. It may not necessarily be applicable to this product.

NCBI GI #

61213023

NCBI GeneID

27103

NCBI Accession #

Q9QZ05.2

UniProt Primary Accession #

Q9QZ05

UniProt Secondary Accession #

Q6GQT4; Q6ZPT5; Q8C5S0; Q8CIF5; Q9CT30; Q9CUV9; Q9ESB6; Q9ESB7; Q9ESB8; A2AUM3; A2AUM4

UniProt Related Accession #

Q9QZ05

NCBI Official Full Name

Eukaryotic translation initiation factor 2-alpha kinase 4

NCBI Official Synonym Full Names

eukaryotic translation initiation factor 2 alpha kinase 4

NCBI Official Symbol

Eif2ak4

NCBI Official Synonym Symbols

GCN2; MGCN2; 2610011M03

UniProt Protein Name

Eukaryotic translation initiation factor 2-alpha kinase 4

UniProt Synonym Protein Names

GCN2-like protein; mGCN2

Protein Family

eIF-2-alpha kinase

UniProt Gene Name

Eif2ak4

UniProt Synonym Gene Names

Gcn2; Kiaa1338; mGCN2

UniProt Entry Name

E2AK4_MOUSE

NCBI Protein Information

eukaryotic translation initiation factor 2-alpha kinase 4; GCN2-like protein; GCN2 eIF2alpha kinase

UniProt Comments for EIF2AK4

GCN2: a kinase of the PEK family. Phosphorylates and inhibits eukaryotic initiation factor (eIF)-2 alpha, providing an important protective mechanism during various cellular stress conditions including endoplasmic reticulum (ER) stress.

Protein type: Protein kinase, Other; Kinase, protein; Translation; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Other group; PEK family; GCN2 subfamily

Molecular Function: transferase activity; protein serine/threonine kinase activity; protein homodimerization activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; eukaryotic translation initiation factor 2alpha kinase activity; ATP binding; protein kinase activity

Biological Process: regulation of translation initiation in response to stress; unfolded protein response; negative regulation of translation; cellular response to starvation; protein amino acid phosphorylation; phosphorylation; regulation of translational initiation

Research Articles on EIF2AK4

1. Deletion of the eIF2alpha Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-EIF2AK4 antibody

Products by Pathway	Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Hepatitis C Pathway antibodies	Hepatitis C Pathway Diagram
Hepatitis C Pathway antibodies	Hepatitis C Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Influenza A Pathway antibodies	Influenza A Pathway Diagram
Influenza A Pathway antibodies	Influenza A Pathway Diagram
Measles Pathway antibodies	Measles Pathway Diagram
Measles Pathway antibodies	Measles Pathway Diagram

Diseases associated with anti-EIF2AK4 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>7 publications with EIF2AK4 and Inflammation
Immune System Diseases Antibodies	>7 publications with EIF2AK4 and Immune System Diseases
Necrosis Antibodies	>5 publications with EIF2AK4 and Necrosis
Disease Models, Animal Antibodies	>5 publications with EIF2AK4 and Disease Models, Animal
Pulmonary Veno-Occlusive Disease Antibodies	>4 publications with EIF2AK4 and Pulmonary Veno-Occlusive Disease
Weight Loss Antibodies	>4 publications with EIF2AK4 and Weight Loss
Drug-Induced Liver Injury Antibodies	>3 publications with EIF2AK4 and Drug-Induced Liver Injury
Lymphoma Antibodies	>3 publications with EIF2AK4 and Lymphoma
Hypertension, Pulmonary Antibodies	>3 publications with EIF2AK4 and Hypertension, Pulmonary
Poisoning Antibodies	>2 publications with EIF2AK4 and Poisoning

Organs/Tissues associated with anti-EIF2AK4 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>26 publications with EIF2AK4 and Blood
Brain Antibodies	>12 publications with EIF2AK4 and Brain
Muscle Antibodies	>6 publications with EIF2AK4 and Muscle
Kidney Antibodies	>5 publications with EIF2AK4 and Kidney
Pancreas Antibodies	>4 publications with EIF2AK4 and Pancreas
Spleen Antibodies	>3 publications with EIF2AK4 and Spleen
Intestine Antibodies	>2 publications with EIF2AK4 and Intestine
Thymus Antibodies	>1 publications with EIF2AK4 and Thymus
Heart Antibodies	>1 publications with EIF2AK4 and Heart
Embryonic Tissue Antibodies	>1 publications with EIF2AK4 and Embryonic Tissue