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Integrin Alpha 1 (ITGA1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS177089

Description: Rabbit IgG polyclonal antibody for Integrin alpha-1(ITGA1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.Background: Integrin alpha 1(ITGA1) chain associates with the beta 1(ITGB1) chain to form a heterodimer that functions as a dual… More details

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Product Overview

Online Datasheet in PDF
Product Name
Integrin alpha 1 (ITGA1), Polyclonal Antibody
Full Product Name
Anti-Integrin alpha 1 antibody
Product Gene Name
anti-ITGA1 antibody
Product Synonym Names
Integrin alpha-1; integrin, alpha 1; CD 49a antibody; CD49 antigen-like family member A antibody; CD49a antibody; CD49a antigen antibody; Integrin alpha-1 antibody; ITA1_HUMAN antibody; Itga 1 antibody; ITGA1 antibody; Laminin and collagen receptor antibody; Very late activation protein 1 antibody; VLA 1 antibody; VLA-1 antibody; VLA1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Predicted to work with: mouse.
Form/Format
Lyophilized
Each vial contains 4 mg Trehalose, 0.9 mg NaCI and 0.2 mg Na2HPO4.
Purity/Purification
Immunogen affinity purified.
Specificity
No cross reactivity with other proteins .
Preparation and Storage
At -20°C for one year from date of receipt. After reconstition at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.
Avoid repeated freezing and thawing.
Molecular Weight
130,848 Da
OMIM
192968
3D Structure
ModBase 3D Structure for P56199
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Integrin alpha 1 (1121-1134aa SNQKRELAIQISKD), different from the related mouse and rat sequences by one amino acid.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-ITGA1 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes for anti-ITGA1 antibody
Western blot

Concentration: 0.1-0.5 ug/mL
Tested Species: Hu, Rat
Predicted Species: Ms


Immunohistochemistry (Paraffin-embedded Section)

Concentration: 0.5- 1 ug/mL
Tested Species: Hu, Rat
Predicted Species: Ms
Antigen Retrieval: By Heat


Tested Species: In house tested species with positive results.
Predicted Species: Species predicted to be fit for the product based on sequence similarities.
By Heat: Boiling the paraffin sections in 10mM citrate buffer, ph 6.0 for 20 mins is required for the staining of formalin/ paraffin sections.

Other applications have not been tested.

Optimal dilutions should be determined by end users.

Immunohistochemistry (IHC) of anti-ITGA1 antibody

Anti-Integrin alpha 1 antibody, MBS177089, IHC(P)
IHC(P): Human Lung Cancer Tissue
Rabbit Anti-ITGA1 Polyclonal Antibody – Cat# MBS177089

Immunohistochemistry (IHC) of anti-ITGA1 antibody

Anti-Integrin alpha 1 antibody, MBS177089, IHC(P)
IHC(P): Human Intestinal Cancer Tissue
Rabbit Anti-ITGA1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177089

Immunohistochemistry (IHC) of anti-ITGA1 antibody

Anti-Integrin alpha 1 antibody, MBS177089, IHC(P)
IHC(P): Rat Intestine Tissue
Rabbit Anti-ITGA1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177089

Western Blot (WB) of anti-ITGA1 antibody

Anti-Integrin alpha 1 antibody, MBS177089,Western blotting
All lanes: Anti ITGA1 (MBS177089) at 0.5ug/ml
Lane 1: Rat Brain Tissue Lysate at 50ug
Lane 2: HELA Whole Cell Lysate at 40ug
Lane 3: SW620 Whole Cell Lysate at 40ug
Predicted bind size: 131KD
Observed bind size: 131KD
Rabbit Anti-ITGA1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS177089

Other Notes

Small volumes of anti-ITGA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ITGA1 purchase

MBS177089 is an antibody targeting ITGA1. Also known as Anti-Integrin alpha 1 antibody. Reactive in Human, Mouse, Rat
Predicted to work with: mouse.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ITGA1. It may not necessarily be applicable to this product.

NCBI GI #
124056463
NCBI GeneID
3672
NCBI Accession #
P56199.2
UniProt Primary Accession #
P56199
UniProt Secondary Accession #
B2RNU0
UniProt Related Accession #
P56199
NCBI Official Full Name
Integrin alpha-1
NCBI Official Synonym Full Names
integrin, alpha 1
NCBI Official Symbol
ITGA1
NCBI Official Synonym Symbols
VLA1; CD49a
UniProt Protein Name
Integrin alpha-1
UniProt Synonym Protein Names
CD49 antigen-like family member A; Laminin and collagen receptor; VLA-1; CD_antigen: CD49a
Protein Family
Integrin
UniProt Gene Name
ITGA1
UniProt Entry Name
ITA1_HUMAN
NCBI Protein Information
integrin alpha-1; VLA-1; laminin and collagen receptor; very late activation protein 1; CD49 antigen-like family member A

NCBI Summary for ITGA1

This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008]
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UniProt Comments for ITGA1

ITGA1: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Belongs to the integrin alpha chain family.

Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: neuron projection; focal adhesion; cell surface; membrane; acrosome; plasma membrane; perikaryon; integrin complex; lipid raft; external side of plasma membrane

Molecular Function: collagen binding; protein binding; metal ion binding; protein phosphatase binding; receptor binding

Biological Process: positive regulation of phosphoprotein phosphatase activity; negative regulation of epidermal growth factor receptor signaling pathway; integrin-mediated signaling pathway; axon guidance; neutrophil chemotaxis; extracellular matrix organization and biogenesis; activation of MAPK activity; cell-matrix adhesion; vasodilation; negative regulation of cell proliferation; muscle contraction; cellular extravasation; positive regulation of neuron apoptosis; blood coagulation
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Research Articles on ITGA1

1. 17-beta-estradiol modulates connexins and integrins as well as ER-beta expression induced by high frequency electromagnetic fields.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ITGA1 antibody

 Reference Product  PubMed Publications
 ITGB2 antibody  >1 publications with ITGA1 and ITGB2
 ITGB5 antibody  >1 publications with ITGA1 and ITGB5
 LAMA1 antibody  >1 publications with ITGA1 and LAMA1
 ITGB1 antibody  >1 publications with ITGA1 and ITGB1

Pathways associated with anti-ITGA1 antibody

 Products by Pathway  Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CHL1 Interactions Pathway antibodies  CHL1 Interactions Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram

Diseases associated with anti-ITGA1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4 publications with ITGA1 and Inflammation
 Fibrosis Antibodies  >2 publications with ITGA1 and Fibrosis
 Necrosis Antibodies  >2 publications with ITGA1 and Necrosis
 Nervous System Malformations Antibodies  >1 publications with ITGA1 and Nervous System Malformations
 Breast Neoplasms Antibodies  >1 publications with ITGA1 and Breast Neoplasms
 Prostatic Diseases Antibodies  >1 publications with ITGA1 and Prostatic Diseases
 Cardiovascular Diseases Antibodies  >1 publications with ITGA1 and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >1 publications with ITGA1 and Lung Neoplasms
 Ovarian Neoplasms Antibodies  >1 publications with ITGA1 and Ovarian Neoplasms
 Cognition Disorders Antibodies  >1 publications with ITGA1 and Cognition Disorders

Organs/Tissues associated with anti-ITGA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with ITGA1 and Blood
 Bone Antibodies  >6 publications with ITGA1 and Bone
 Vascular Antibodies  >4 publications with ITGA1 and Vascular
 Muscle Antibodies  >4 publications with ITGA1 and Muscle
 Placenta Antibodies  >3 publications with ITGA1 and Placenta
 Heart Antibodies  >3 publications with ITGA1 and Heart
 Brain Antibodies  >3 publications with ITGA1 and Brain
 Liver Antibodies  >2 publications with ITGA1 and Liver
 Skin Antibodies  >1 publications with ITGA1 and Skin
 Adipose Tissue Antibodies  >1 publications with ITGA1 and Adipose Tissue
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