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CD32/Fcgr2b/C (FCGR2B) ELISA Kit for Mouse

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS177379

Description: Sandwich ELISA kit of Quantitative Detection for Mouse CD32/FCGR2b/cBackground: CD32 is a surface receptor protein and part of a large population of B cell co-receptors, which act to modulate signaling. It has a low-affinity for IgG antibodies… More details

$895 / 96-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD32/FCGR2b/c, ELISA Kit
Full Product Name
Mouse CD32/FCGR2b/c PicoKine ELISA Kit
Product Gene Name
FCGR2B elisa kit
Product Synonym Names
Low affinity immunoglobulin gamma Fc region receptor II-b; Fc fragment of IgG, low affinity IIb, receptor (CD32); CD 32; CD32; CD32 antigen; CD32A; CD32B; CD32C; CDw32; Fc fragment of IgG low affinity II receptor for (CD32); Fc fragment of IgG low affinity IIa receptor; Fc fragment of IgG low affinity IIa receptor for (CD32); Fc fragment of IgG low affinity IIb receptor; Fc fragment of IgG low affinity IIb receptor for (CD32); Fc fragment of IgG low affinity IIc receptor; Fc fragment of IgG low affinity IIc receptor for (CD32); Fc gamma receptor IIB; Fc gamma RII a; Fc gamma RII b; Fc gamma RII c; Fc gamma RIIa; Fc gamma RIIb ; Fc gamma RIIc; Fc receptor, IgG, low affinity IIb; Fc-gamma RII-a; Fc-gamma RII-b; Fc-gamma RII-c; Fc-gamma-RIIa; FC-gamma-RIIB; Fc-GAMMA-RIIC; Fc[g]RII; FCG 2; FCG2; FCG2A_HUMAN; FcgammaRIIC; FCGR 2; FcGR; FCGR2; FCGR2A; FCGR2A1; FCGR2B; FCGR2C; Fcgr3; Fcgr3a; FcgRII; Fcr-2; Fcr-3; FcRII a; FCRII; FcRII b; FcRII c; FcRII-a; FcRIIC; IGFR 2; IGFR2; IgG Fc receptor II a; IgG Fc receptor II b; IgG Fc receptor II beta; IgG Fc receptor II c; IgG Fc receptor II-a; IgG Fc receptor II-b; IgG Fc receptor II-c; Immunoglobulin G Fc receptor II; Low affinity; immunoglobulin gamma Fc region receptor II a; Low affinity immunoglobulin gamma Fc region receptor II; Low affinity immunoglobulin gamma Fc region receptor II b; Low affinity immunoglobulin gamma Fc region receptor II c; Low affinity immunoglobulin gamma Fc region receptor II-a; Low affinity immunoglobulin gamma Fc region receptor II-b; Low affinity immunoglobulin gamma Fc region receptor II-c; Ly-17; Ly-m20; LyM-1; Lymphocyte antigen 17; MGC23887; MGC30032
Species Reactivity
Mouse
Assay Type
Sandwich
Samples
Cell culture supernates, serum and plasma (heparin, EDTA)
Detection Range
31.2pg/ml-2000pg/ml
Sensitivity
<10pg/ml
Preparation and Storage
Store at 4 degree C for 6 months, at -20 degree C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
Molecular Weight
– Da
3D Structure
ModBase 3D Structure for P08101
Production Time
Due to severe delay and raw materials shortage, production time may takes between 5-8 weeks.
Immunogen
NSO, T40-R217
Reactivity Note
Mouse. There is no detectable cross-reactivity with other relevant proteins.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data/Standard Curve (for reference only) of FCGR2B elisa kit

Mouse CD32/FCGR2b/c PicoKine ELISA Kit standard curve
Mouse FCGR2B ELISA Kit – Cat# MBS177379

Other Notes

Small volumes of FCGR2B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FCGR2B purchase

MBS177379 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the CD32/FCGR2b/c, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FCGR2B. The ELISA analytical biochemical technique of the MBS177379 kit is based on FCGR2B antibody-FCGR2B antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FCGR2B antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FCGR2B. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for FCGR2B. It may not necessarily be applicable to this product.

NCBI GI #
2506779
NCBI GeneID
14130
NCBI Accession #
P08101.2
UniProt Primary Accession #
P08101
UniProt Secondary Accession #
P08102; P12316; P97917; Q60938; Q60939; Q60940; Q61170; Q61558
UniProt Related Accession #
P08101
NCBI Official Full Name
Low affinity immunoglobulin gamma Fc region receptor II
NCBI Official Synonym Full Names
Fc receptor, IgG, low affinity IIb
NCBI Official Symbol
Fcgr2b
NCBI Official Synonym Symbols
CD32; Fcgr2; Fcr-2; Fcr-3; Ly-17; LyM-1; Lym-1; fcRII; FcgRII; Fcgr2a; Ly-m20; AI528646; Fc[g]RII; F630109E10Rik
UniProt Protein Name
Low affinity immunoglobulin gamma Fc region receptor II
UniProt Synonym Protein Names
Fc gamma receptor IIB; Fc-gamma RII; Fc-gamma-RIIB; FcRII; IgG Fc receptor II beta; Lymphocyte antigen 17; Ly-17; CD_antigen: CD32
Protein Family
Low affinity immunoglobulin gamma Fc region receptor
UniProt Gene Name
Fcgr2
UniProt Synonym Gene Names
Fcgr2b; Ly-17; Fc-gamma RII; Fc-gamma-RIIB; FcRII; Ly-17
UniProt Entry Name
FCGR2_MOUSE
NCBI Protein Information
low affinity immunoglobulin gamma Fc region receptor II-b; FcgammaRIIB; Fc-gamma-RII; fc-gamma RII; Fc gamma RIIB; fc-gamma-RIIB; fc gamma receptor IIB; lymphocyte antigen 17; igG Fc receptor II beta

UniProt Comments for FCGR2B

FCGR2B: a transmembrane receptor for the Fc region of complexed or aggregated immunoglobulin gamma (IgG). Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down modulation of previous state of cell activation triggered via antigen receptors on B cells, T cells or via another Fc receptor. Three splice-variant isoforms have been observed.

Protein type: Cell surface; Membrane protein, integral; Oncoprotein

Cellular Component: recycling endosome; cytoskeleton; cell surface; membrane; integral to plasma membrane; cytoplasm; plasma membrane; integral to membrane; extracellular region; lipid raft; external side of plasma membrane

Molecular Function: protein binding; IgG binding; receptor signaling protein activity; immunoglobulin binding

Biological Process: negative regulation of phagocytosis; receptor-mediated endocytosis; negative regulation of interleukin-10 production; negative regulation of acute inflammatory response to antigenic stimulus; negative regulation of immune response; antigen processing and presentation of exogenous peptide antigen via MHC class II; defense response; negative regulation of B cell proliferation; endocytic recycling; negative regulation of type I hypersensitivity; mast cell activation; negative regulation of neutrophil apoptosis; negative regulation of humoral immune response mediated by circulating immunoglobulin; cell surface receptor linked signal transduction; response to bacterium; positive regulation of phagocytosis; negative regulation of immunoglobulin production; immune complex clearance; negative regulation of inflammatory response to antigenic stimulus; immune response; immunoglobulin mediated immune response; phagocytosis, engulfment
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Research Articles on FCGR2B

1. These results suggest that respiratory syncytial virus persistence in macrophages induce intracellular effects that have an impact on Fcgamma receptor gene expression at both mRNA and protein levels.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FCGR2B elisa kit

 Reference Product  PubMed Publications
 Lyn elisa kit  >2 publications with FCGR2B and Lyn
 Lpl elisa kit  >2 publications with FCGR2B and Lpl
 Lilrb3 elisa kit  >1 publications with FCGR2B and Lilrb3

Pathways associated with FCGR2B elisa kit

 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 FCGR Activation Pathway antibodies  FCGR Activation Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram

Diseases associated with FCGR2B elisa kit

 Disease Name  Pubmed Publications
 Autoimmune Diseases Antibodies  >126 publications with FCGR2B and Autoimmune Diseases
 Lupus Erythematosus, Systemic Antibodies  >66 publications with FCGR2B and Lupus Erythematosus, Systemic
 Inflammation Antibodies  >46 publications with FCGR2B and Inflammation
 Kidney Diseases Antibodies  >25 publications with FCGR2B and Kidney Diseases
 Necrosis Antibodies  >17 publications with FCGR2B and Necrosis
 Nervous System Diseases Antibodies  >16 publications with FCGR2B and Nervous System Diseases
 Lung Diseases Antibodies  >13 publications with FCGR2B and Lung Diseases
 Skin Diseases Antibodies  >7 publications with FCGR2B and Skin Diseases
 Anemia Antibodies  >5 publications with FCGR2B and Anemia
 Liver Diseases Antibodies  >3 publications with FCGR2B and Liver Diseases

Organs/Tissues associated with FCGR2B elisa kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >177 publications with FCGR2B and Blood
 Spleen Antibodies  >28 publications with FCGR2B and Spleen
 Bone Antibodies  >20 publications with FCGR2B and Bone
 Bone Marrow Antibodies  >18 publications with FCGR2B and Bone Marrow
 Lung Antibodies  >8 publications with FCGR2B and Lung
 Artery Antibodies  >8 publications with FCGR2B and Artery
 Liver Antibodies  >5 publications with FCGR2B and Liver
 Thymus Antibodies  >3 publications with FCGR2B and Thymus
 Skin Antibodies  >3 publications with FCGR2B and Skin
 Embryonic Tissue Antibodies  >2 publications with FCGR2B and Embryonic Tissue
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