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Antigen (CD82) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS177492

Description: Rabbit IgG polyclonal antibody for CD82 antigen(CD82) detection. Tested with WB, IHC-P in Human.Background: CD82(Cluster of Differentiation 82), also named KAI1, is a protein that in humans encoded by the CD82 gene. The gene is mapped to 11p11.2.… More details

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Product Overview

Online Datasheet in PDF
Product Name
CD82 antigen, Polyclonal Antibody
Full Product Name
Anti-CD82 Antibody
Product Gene Name
anti-CD82 antibody
Product Synonym Names
4F9 antibody; Antigen detected by monoclonal and antibody IA4 antibody; C33 antibody; C33 antigen antibody; CD 82 antibody; CD82 antibody; Cd82 antibody; CD82 antigen antibody; CD82 molecule antibody; CD82_HUMAN antibody; GR 15 antibody; GR15 antibody; IA 4 antibody; IA4 antibody; Inducible membrane protein antibody; Inducible membrane protein R2 antibody; KAI 1 antibody; KAI1 antibody; Kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4)) antibody; Kangai 1 antibody; Kangai1 antibody; Leukocyte surface antigen R2 antibody; Metastasis suppressor Kangai 1 antibody; Metastasis suppressor Kangai-1 antibody; Metastasis suppressor Kangai1 antibody; Prostate cancer antimetastasis gene KAI1 antibody; R2 antibody; R2 leukocyte antigen antibody; SAR 2 antibody; SAR2 antibody; ST 6 antibody; ST6 antibody; Suppression of tumorigenicity 6 antibody; Suppression of tumorigenicity 6 prostate antibody; Suppressor of tumorigenicity 6 antibody; Suppressor of tumorigenicity 6 protein antibody; Tetraspanin 27 antibody; Tetraspanin-27 antibody; Tetraspanin27 antibody; Tspan 27 antibody; Tspan-27 antibody; Tspan27 antibody; CD82 molecule
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human. No cross reactivity with other proteins.
Form/Format
Lyophilized
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
26,818 Da
OMIM
600623
3D Structure
ModBase 3D Structure for P27701
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Immunogen
E.coli-derived human CD82 recombinant protein (Position: A98-Y267). Human CD82 shares 69% and 67% amino acid (aa) sequences identity with mouse and rat CD82, respectively.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CD82 antibody
Western Blot (WB), Immunohistochemistry (IHC-P)
Application Notes for anti-CD82 antibody
Western Blot: Concentration: 0.1-0.5mug/ml; Tested Species: Human
Immunohistochemistry (Paraffin-embedded Section): Concentration: 0.5-1mug/ml; Tested Species: Human

Western Blot (WB) of anti-CD82 antibody

Anti-CD82 Picoband antibody, MBS177492, Western blotting
All lanes: Anti CD82 (MBS177492) at 0.5ug/ml
WB: Recombinant Human CD82 Protein 0.5ng
Predicted bind size: 36KD
Observed bind size: 36KD
Rabbit Anti-CD82 Polyclonal Antibody – Cat# MBS177492

Western Blot (WB) of anti-CD82 antibody

Anti- CD82 Picoband antibody, MBS177492, Western blotting
All lanes: Anti CD82 (MBS177492) at 0.5ug/ml
Lane 1: HL-60 Whole Cell Lysate at 40ug
Lane 2: CEM Whole Cell Lysate at 40ug
Lane 3: HUT Whole Cell Lysate at 40ug
Lane 4: U937 Whole Cell Lysate at 40ug
Lane 5: MCF-7 Whole Cell Lysate at 40ug
Predicted bind size: 30KD
Observed bind size: 30KD
Rabbit Anti-CD82 Polyclonal Antibody, Western Blot (WB) – Cat# MBS177492

Immunohistochemistry (IHC) of anti-CD82 antibody

Anti-CD82 Picoband antibody, MBS177492, IHC(P)
IHC(P): Human Tonsil Tissue
Rabbit Anti-CD82 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177492

Other Notes

Small volumes of anti-CD82 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD82 purchase

MBS177492 is an antibody targeting CD82. Reactive in Human. No cross reactivity with other proteins.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD82. It may not necessarily be applicable to this product.

NCBI GI #
67782354
NCBI GeneID
3732
NCBI Accession #
NP_001020015.1
UniProt Primary Accession #
P27701
UniProt Secondary Accession #
Q7Z2D4; Q7Z5N2; D3DQN6; E9PC70
UniProt Related Accession #
P27701
GenBank Nucleotide #
NM_001024844.1
NCBI Official Full Name
CD82 antigen isoform 2
NCBI Official Synonym Full Names
CD82 molecule
NCBI Official Symbol
CD82
NCBI Official Synonym Symbols
R2; 4F9; C33; IA4; ST6; GR15; KAI1; SAR2; TSPAN27
UniProt Protein Name
CD82 antigen
UniProt Synonym Protein Names
C33 antigen; IA4; Inducible membrane protein R2; Metastasis suppressor Kangai-1; Suppressor of tumorigenicity 6 protein; Tetraspanin-27; Tspan-27; CD_antigen: CD82
Protein Family
CD82 antigen
UniProt Gene Name
CD82
UniProt Synonym Gene Names
KAI1; SAR2; ST6; TSPAN27; Tspan-27
UniProt Entry Name
CD82_HUMAN
NCBI Protein Information
CD82 antigen; tspan-27; C33 antigen; tetraspanin-27; inducible membrane protein R2; metastasis suppressor Kangai-1; kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))

NCBI Summary for CD82

This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD82

CD82: a widespread transmembrane protein of the tetraspanin family. A metastasis-suppressor whose decreased expression may be involved in malignant progression. Suppresses tumor metastasis of many cancers including cancers of the prostate, bladder, colon, cervix, liver, and lung (NSCLC). It is a target of estrogen receptor-mediated gene repression and is downregulated in primary human breast cancer. May be a prognostic marker for lung cancer and tumor metastatic potential. Interacts with cell surface proteins including integrins, cadherins, CD4, CD8, IGSF8. Modulates EGFR signaling. May suppress invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases. Its regulation of c-Met signaling apparently affects cancer cell migration.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding

Disease: Prostate Cancer
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Research Articles on CD82

1. clear cell renal cell carcinoma patients with CD82 positive expression show poor prognosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD82 antibody

 Reference Product  PubMed Publications
 EGFR antibody  >17 publications with CD82 and EGFR
 CD4 antibody  >15 publications with CD82 and CD4
 MET antibody  >12 publications with CD82 and MET
 CD19 antibody  >6 publications with CD82 and CD19
 APBB1 antibody  >3 publications with CD82 and APBB1
 TP53 antibody  >3 publications with CD82 and TP53
 PRKCA antibody  >1 publications with CD82 and PRKCA

Pathways associated with anti-CD82 antibody

 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram

Diseases associated with anti-CD82 antibody

 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >164 publications with CD82 and Neoplasm Metastasis
 Neoplasm Invasiveness Antibodies  >67 publications with CD82 and Neoplasm Invasiveness
 Adenocarcinoma Antibodies  >56 publications with CD82 and Adenocarcinoma
 Prostatic Neoplasms Antibodies  >46 publications with CD82 and Prostatic Neoplasms
 Prostatic Diseases Antibodies  >42 publications with CD82 and Prostatic Diseases
 Breast Neoplasms Antibodies  >30 publications with CD82 and Breast Neoplasms
 Liver Neoplasms Antibodies  >28 publications with CD82 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >18 publications with CD82 and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >14 publications with CD82 and Carcinoma, Hepatocellular
 Hyperplasia Antibodies  >13 publications with CD82 and Hyperplasia

Organs/Tissues associated with anti-CD82 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >71 publications with CD82 and Blood
 Prostate Antibodies  >65 publications with CD82 and Prostate
 Lymph Node Antibodies  >59 publications with CD82 and Lymph Node
 Lymph Antibodies  >59 publications with CD82 and Lymph
 Lung Antibodies  >54 publications with CD82 and Lung
 Liver Antibodies  >32 publications with CD82 and Liver
 Stomach Antibodies  >17 publications with CD82 and Stomach
 Uterus Antibodies  >14 publications with CD82 and Uterus
 Bone Marrow Antibodies  >12 publications with CD82 and Bone Marrow
 Placenta Antibodies  >10 publications with CD82 and Placenta
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