RAC1 Antibody – Polyclonal

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

RAC1: a plasma membrane-associated member of the Rho-GTPase family. Plays a key role in cytoskeletal reorganization, membrane trafficking, transcriptional regulation and cell growth and development. GTP binding stimulates its activity. Phosphorylation by Akt may inhibit GTP binding of Rac1, therefore attenuating the downstream signal transduction pathway. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Two alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; G protein, monomeric, Rho; G protein, monomeric; G protein

Chromosomal Location of Human Ortholog: 7p22

Cellular Component: actin filament; cytoplasm; cytosol; early endosome membrane; endoplasmic reticulum membrane; extrinsic to plasma membrane; focal adhesion; Golgi membrane; lamellipodium; melanosome; membrane; nucleus; phagocytic cup; plasma membrane; trans-Golgi network

Molecular Function: enzyme binding; GTP binding; GTP-dependent protein binding; GTPase activity; histone deacetylase binding; protein binding; protein kinase binding; Rab GTPase binding; Rho GDP-dissociation inhibitor binding; thioesterase binding

Biological Process: actin cytoskeleton organization and biogenesis; actin filament polymerization; anatomical structure morphogenesis; auditory receptor cell morphogenesis; axon guidance; blood coagulation; bone resorption; cell adhesion; cell motility; cell motility involved in cell locomotion; cell proliferation; cell-matrix adhesion; cerebral cortex GABAergic interneuron development; cerebral cortex radially oriented cell migration; dendrite morphogenesis; embryonic olfactory bulb interneuron precursor migration; engulfment of apoptotic cell; ephrin receptor signaling pathway; G-protein coupled receptor protein signaling pathway; homeostasis of number of cells within a tissue; hyperosmotic response; inflammatory response; intercellular junction assembly and maintenance; lamellipodium biogenesis; localization within membrane; mast cell chemotaxis; metabolic process; negative regulation of interleukin-23 production; negative regulation of receptor-mediated endocytosis; organization of an anatomical structure; platelet activation; positive regulation of actin filament polymerization; positive regulation of apoptosis; positive regulation of DNA replication; positive regulation of focal adhesion formation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of protein amino acid phosphorylation; positive regulation of Rho protein signal transduction; positive regulation of stress fiber formation; protein transport; regulation of cell migration; regulation of cell size; regulation of defense response to virus by virus; regulation of hydrogen peroxide metabolic process; regulation of neuron maturation; regulation of small GTPase mediated signal transduction; response to wounding; ruffle organization and biogenesis; small GTPase mediated signal transduction; synaptic transmission, GABAergic; T cell costimulation; vascular endothelial growth factor receptor signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway