PKC iota Antibody – Polyclonal

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]

PKCI: an AGC protein kinase of the PKC family. A calcium-independent, phospholipid-dependent atypical protein kinase C. Is not activated by phorbolesters or diaglycerol. May play role in the secretory response to nutrients. Involved in cell polarization processes and the formation of epithelial tight junctions. Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets.

Protein type: Kinase, protein; Tumor suppressor; Cell development/differentiation; EC 2.7.11.13; Oncoprotein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Cell adhesion; Protein kinase, AGC; AGC group; PKC family; Iota subfamily

Chromosomal Location of Human Ortholog: 3q26.3

Cellular Component: apical plasma membrane; cytoplasm; cytosol; endosome; Golgi membrane; intercellular bridge; leading edge; microtubule cytoskeleton; nucleus; plasma membrane; protein complex; tight junction

Molecular Function: ATP binding; metal ion binding; phospholipid binding; protein binding; protein domain specific binding; protein kinase activity; protein kinase C activity; protein serine/threonine kinase activity

Biological Process: actin filament organization; activation of NF-kappaB transcription factor; cell migration; cellular response to insulin stimulus; cytoskeleton organization and biogenesis; establishment and/or maintenance of epithelial cell polarity; establishment of apical/basal cell polarity; eye photoreceptor cell development; Golgi vesicle budding; intercellular junction assembly and maintenance; negative regulation of apoptosis; negative regulation of neuron apoptosis; peptidyl-serine phosphorylation; positive regulation of glucose import; protein amino acid phosphorylation; protein targeting to membrane; secretion; vesicle-mediated transport