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ING1 Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178236

Description: Rabbit IgG polyclonal antibody for Inhibitor of growth protein 1(ING1) detection. Tested with WB in Human.Background: Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene. It is mapped to 13q34. This gene encodes… More details

$210 / 0.01 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
ING1, Polyclonal Antibody
Full Product Name
Anti-ING1 Antibody
Product Gene Name
Product Synonym Names
Inhibitor of growth protein 1; 2610028J21Rik; AA407184; AI875420; Growth inhibitor ING 1; Growth inhibitor ING1; Growth inhibitory protein ING 1; Growth inhibitory protein ING1; Homo sapiens growth inhibitor p33ING1 (ING1) mRNA, complete cds; ING 1; Ing1; ING1_HUMAN; Inhibitor of growth 1; Inhibitor of growth family member 1; Inhibitor of growth protein 1; mING1h; OTTHUMP00000018703; OTTHUMP00000018704; OTTHUMP00000018705; OTTHUMP00000018706; p24ING1c; p33; p33 ING1; p33ING1; p33ING1b; p33ING1c; p37Ing1b; p47; p47ING1a; Tumor suppressor ING 1; Tumor suppressor ING1; inhibitor of growth family, member 1
Clonality
Polyclonal
Species Reactivity
Human
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
29,572 Da
OMIM
275355
3D Structure
ModBase 3D Structure for Q9UK53
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human ING1 (192-223aa KELDECYERFSRETDGAQKRRMLHCVQRALIR), different from the related mouse sequence by seven amino acids.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-ING1 antibody
Western Blot (WB)
Application Notes for anti-ING1 antibody
Western Blot Concentration: 0.1-0.5ug/ml

Western Blot (WB) of anti-ING1 antibody

Anti- ING1 Picoband antibody, MBS178236, Western blotting
All lanes: Anti ING1 (MBS178236) at 0.5ug/ml
Lane 1: HELA Whole Cell Lysate at 40ug
Lane 2: A549 Whole Cell Lysate at 40ug
Predicted bind size: 47KD
Observed bind size: 47KD
Anti-ING1 Polyclonal Antibody – Cat# MBS178236

Product References and Citations for anti-ING1 antibody

1. "Entrez Gene: ING1 inhibitor of growth family, member 1". 2. Garkavtsev I, Kazarov A, Gudkov A, Riabowol K (Jan 1997). "Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation". Nat Genet 14 (4): 415-20. 3. Garkavtsev I, Demetrick D, Riabowol K (Jul 1997). "Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1)". Cytogenet Cell Genet 76 (3-4): 176-8.

Other Notes

Small volumes of anti-ING1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ING1 purchase

MBS178236 is an antibody targeting ING1. Reactive in Human.

Additional Details

NCBI/Uniprot data below describe general gene information for ING1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
inhibitor of growth protein 1 isoform E
NCBI Official Synonym Full Names
inhibitor of growth family member 1
NCBI Official Symbol
ING1
NCBI Official Synonym Symbols
p33; p47; p33ING1; p24ING1c; p33ING1b; p47ING1a
UniProt Protein Name
Inhibitor of growth protein 1
UniProt Gene Name
ING1
UniProt Entry Name
ING1_HUMAN
NCBI Protein Information
inhibitor of growth protein 1

NCBI Summary for ING1

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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UniProt Comments for ING1

ING1: Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene. Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC); also known as squamous cell carcinoma of the head and neck. Belongs to the ING family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: methylated histone residue binding; protein binding; zinc ion binding

Biological Process: cell cycle; chromatin modification; negative regulation of cell growth; negative regulation of cell proliferation

Disease: Squamous Cell Carcinoma, Head And Neck
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ING1 antibody

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