SLC17A7 Antibody – Mouse Monoclonal

The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008]

SLC17A7: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.

Protein type: Transporter, SLC family; Membrane protein, integral; Vesicle; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 19q13

Cellular Component: cell junction; excitatory synapse; integral to membrane; plasma membrane; presynaptic active zone; synaptic vesicle membrane

Molecular Function: extracellular-glutamate-gated chloride channel activity; inorganic phosphate transmembrane transporter activity; L-glutamate transmembrane transporter activity; sodium-dependent phosphate transmembrane transporter activity; sodium:inorganic phosphate symporter activity

Biological Process: brain development; glutamate secretion; ion transport; L-glutamate import; long-term memory; neurotransmitter transport; phosphate transport; regulation of excitatory postsynaptic membrane potential; sequestering of neurotransmitter; synaptic transmission, glutamatergic