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ADAM22 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS190912

ADAM22 is a member of the ADAM gene family which bind integrin and may play a role in cell-to-cell or cell-to-matrix interations. ADAM22 is unique in that it is only observed in the nervous system and predominantly in brain. ADAM22 is attached by cytoskeletal… More details

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Testing Data View PDF
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Product Overview

Product Name
ADAM22, Monoclonal Antibody
Full Product Name
ADAM22 (cytoplasmic) Monoclonal Antibody
Product Gene Name
Product Synonym Names
Anti-ADAM22(cytoplasmic)
Clonality
Monoclonal
Isotype
IgG2b
Host
Mouse
Specificity
This antibody recognizes mouse, rat, and human (weak) ADAM22.
Preparation and Storage
This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freeze-thaw cycles.
Molecular Weight
Predicted molecular weight is ~90kDa.
OMIM
603709
Antigen
Fusion protein corresponding to aa 757-857, the cytoplasmic region, of mouse ADAM22 (accession no. Q9R1V6).
Positive Control
Rat brain lysate.
Dilution Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Application Notes for anti-ADAM22 antibody
Immunoblotting: Use at 1ug/ml.

Testing Data of anti-ADAM22 antibody

Mouse Anti-ADAM22 Monoclonal Antibody – Cat# MBS190912

Other Notes

Small volumes of anti-ADAM22 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADAM22 purchase

MBS190912 is an antibody targeting ADAM22. Also known as ADAM22 (cytoplasmic) Monoclonal Antibody. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ADAM22. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ADAM22 protein
NCBI Official Synonym Full Names
ADAM metallopeptidase domain 22
NCBI Official Symbol
ADAM22
NCBI Official Synonym Symbols
MDC2; ADAM 22
UniProt Protein Name
Disintegrin and metalloproteinase domain-containing protein 22
UniProt Synonym Protein Names
Metalloproteinase-disintegrin ADAM22-3; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2
UniProt Gene Name
ADAM22
UniProt Synonym Gene Names
MDC2; ADAM 22
UniProt Entry Name
ADA22_HUMAN
NCBI Protein Information
disintegrin and metalloproteinase domain-containing protein 22

NCBI Summary for ADAM22

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
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UniProt Comments for ADAM22

ADAM22: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7q21

Cellular Component: axon; integral to membrane; plasma membrane

Molecular Function: integrin binding; metalloendopeptidase activity; protein binding; zinc ion binding

Biological Process: adult locomotory behavior; cell adhesion; central nervous system development; myelination in the peripheral nervous system; negative regulation of cell adhesion; proteolysis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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