GluN2A/NR2A Antibody – Mouse Monoclonal

This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

NMDAR2A: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission.

Protein type: Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16p13.2

Cellular Component: cell junction; cell surface; endoplasmic reticulum; integral to plasma membrane; N-methyl-D-aspartate selective glutamate receptor complex; neuron projection; plasma membrane; postsynaptic membrane; presynaptic membrane; synaptic vesicle

Molecular Function: calcium channel activity; extracellular-glutamate-gated ion channel activity; N-methyl-D-aspartate selective glutamate receptor activity; protein binding; Ras guanyl-nucleotide exchange factor activity; zinc ion binding

Biological Process: directional locomotion; dopamine metabolic process; glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; learning and/or memory; MAPKKK cascade; memory; negative regulation of protein catabolic process; neurogenesis; positive regulation of apoptosis; positive regulation of GTPase activity; protein localization; regulation of excitatory postsynaptic membrane potential; regulation of sensory perception of pain; response to amphetamine; response to drug; response to ethanol; response to wounding; sensory perception of pain; serotonin metabolic process; sleep; startle response; synaptic transmission; transport; visual learning

Disease: Epilepsy, Focal, With Speech Disorder And With Or Without Mental Retardation