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TLR7 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS200017

TLR7 is one of toll-like receptors which are type I transmembrane proteins involved in innate immunity by recognizing microbial conserved structures. These proteins are characterized by multiple copies of leucine rich repeats in the extracellular domain and… More details

$285 / 0.05 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
TLR7, Monoclonal Antibody
Full Product Name
TLR7 antibody
Product Gene Name
Product Synonym Names
toll-like receptor 7; PRO285; UNQ248; tlr 7
Clonality
Monoclonal
Isotype
IgG1, k
Clone Number
4F4
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
Purity/Purification
By protein-G affinity chromatography
Concentration
1mg/ml (lot specific)
Preparation and Storage
Can be stored at 4 degree C.
For long term storage, aliquot and store at -20 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
120,922 Da
OMIM
AF240467 mRNA
3D Structure
ModBase 3D Structure for Q9NYK1
Antigen Species
Human
Immunogen
Recombinant human TLR7 (451-500aa) purified from E. coli
Clone Note
Anti-human TLR7 mAb, clone 4F4, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human TLR7 protein.

Product Categories/Family for anti-TLR7 antibody

Applications Tested/Suitable for anti-TLR7 antibody
ELISA (EIA), Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-TLR7 antibody
WB: 1:500 ~ 2,000.
Recommended starting dilution is 1:1,000.

Immunofluorescence (IF) of anti-TLR7 antibody

ICC/IF analysis of TLR7 in THP-1 cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human TLR7 antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).
Mouse Anti-TLR7 Monoclonal Antibody – Cat# MBS200017

Product References and Citations for anti-TLR7 antibody

Lee J., et al. (2003) Proc. Natl. Acad. Sci. USA. 100, 6646-6651; Crozat K., et al. (2004) Proc. Natl. Acad. Sci. USA. 101, 6835-6836; Muzio M., et al. (1998) J. Exp. Med. 187, 2097-2101; Horng T., et al. (2002) Nature 420, 329-333

Other Notes

Small volumes of anti-TLR7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TLR7 purchase

MBS200017 is an antibody targeting TLR7. Also known as TLR7 antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TLR7. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
toll-like receptor 7
NCBI Official Synonym Full Names
toll like receptor 7
NCBI Official Symbol
TLR7
NCBI Official Synonym Symbols
TLR7-like
UniProt Protein Name
Toll-like receptor 7
Protein Family
UniProt Gene Name
TLR7
NCBI Protein Information
toll-like receptor 7

NCBI Summary for TLR7

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008]
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UniProt Comments for TLR7

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response ().
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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