Angiotensinogen (AGT) Antibody – Mouse Monoclonal

angiotensin: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1- 8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2. Genetic variations in AGT are a cause of susceptibility to essential hypertension (EHT). Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable cause. Defects in AGT are a cause of renal tubular dysgenesis (RTD). RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q12

Cellular Component: cytoplasm; extracellular space; mitochondrion

Molecular Function: angiotensin receptor binding; hormone activity; serine-type endopeptidase inhibitor activity; type 1 angiotensin receptor binding; type 2 angiotensin receptor binding

Biological Process: activation of NF-kappaB-inducing kinase; activation of phospholipase C activity; aging; angiotensin mediated drinking behavior; angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure; artery smooth muscle contraction; astrocyte activation; blood vessel development; brain renin-angiotensin system; branching involved in ureteric bud morphogenesis; cell surface receptor signaling pathway; cell-matrix adhesion; cellular sodium ion homeostasis; cytokine secretion; drinking behavior; elevation of cytosolic calcium ion concentration; establishment of blood-nerve barrier; excretion; extracellular matrix organization; female pregnancy; fibroblast proliferation; G-protein coupled receptor signaling pathway; hormone metabolic process; kidney development; negative regulation of angiogenesis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of neuron apoptosis; negative regulation of neurotrophin TRK receptor signaling pathway; negative regulation of tissue remodeling; ovarian follicle rupture; peristalsis; positive regulation of blood pressure; positive regulation of catalytic activity; positive regulation of cell proliferation; positive regulation of cellular protein metabolic process; positive regulation of cytokine secretion; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of fatty acid biosynthetic process; positive regulation of fibroblast proliferation; positive regulation of MAPK cascade; positive regulation of multicellular organism growth; positive regulation of nitric oxide biosynthetic process; positive regulation of organ growth; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of superoxide anion generation; positive regulation of transcription, DNA-templated; regulation of apoptosis; regulation of blood pressure; regulation of calcium ion transport; regulation of gene expression; regulation of heart rate; regulation of inflammatory response; regulation of long-term neuronal synaptic plasticity; regulation of norepinephrine secretion; regulation of renal output by angiotensin; regulation of systemic arterial blood pressure by circulatory renin-angiotensin; regulation of transmission of nerve impulse; renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure; renal system process; renin-angiotensin regulation of aldosterone production; response to cold; response to muscle activity involved in regulation of muscle adaptation; response to salt stress; smooth muscle cell differentiation; smooth muscle cell proliferation; stress-activated MAPK cascade; vasoconstriction; vasodilation