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Annexin A4 (ANXA4) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2001458
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MBS2001458 is an antibody targeting ANXA4. Also known as Polyclonal Antibody to Annexin A4 (ANXA4). Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$215 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Annexin A4 (ANXA4), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Annexin A4 (ANXA4)
Product Gene Name
anti-ANXA4 antibody
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF- GNYLDD ALVRQDAQDL YEAGEKKWGT DEVKFLTVLC SRNRNHLLHV FDEYKRISQK DIEQSIKSET SGSFEDALLA IVKCMRNKSA YFAEKLYKSM
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
0.5mg/ml (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against ANXA4. It has been selected for its ability to recognize ANXA4 in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: ANXA4 (MBS2001458)
Immunogen: ANXA4 (MBS2011517)
Matching Pairs
Unconjugated Antibody: ANXA4 (MBS2001458)
APC-CY7 Conjugated Antibody: ANXA4 (MBS2075397)
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Molecular Weight
27,063 Da
OMIM
M19383 mRNA
3D Structure
ModBase 3D Structure for P09525
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant ANXA4 (Gly165~Met260) expressed in E.coli.
Cross Reactivity
Human, Mouse, Rat
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2075401
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-ANXA4 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-ANXA4 antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-ANXA4 antibody

Western Blot: Sample: Human Liver lysate; Primary Ab: 2ug/ml Rabbit Anti-Human ANXA4 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
Rabbit Anti-ANXA4 Polyclonal Antibody – Cat# MBS2001458

Western Blot (WB) of anti-ANXA4 antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-ANXA4 Polyclonal Antibody, Western Blot (WB) – Cat# MBS2001458

Immunohistochemistry (IHC) of anti-ANXA4 antibody

HE staining on IHC-P; Samples: Human Liver Tissue
Rabbit Anti-ANXA4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2001458

Immunohistochemistry (IHC) of anti-ANXA4 antibody

HE staining on IHC-P; Samples: Human Kidney Tissue.
Rabbit Anti-ANXA4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2001458

Other Notes

Small volumes of anti-ANXA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ANXA4. It may not necessarily be applicable to this product.

NCBI GI #
4502105
NCBI GeneID
307
NCBI Accession #
NP_001144.1
UniProt Primary Accession #
P09525
UniProt Secondary Accession #
Q96F33; Q9BWK1; B4DDF9
UniProt Related Accession #
P09525
GenBank Nucleotide #
NM_001153.4
NCBI Official Full Name
annexin A4 isoform a
NCBI Official Synonym Full Names
annexin A4
NCBI Official Symbol
ANXA4
NCBI Official Synonym Symbols
ANX4; P32.5; PIG28; PP4-X; ZAP36; PAP-II; HEL-S-274
UniProt Protein Name
Annexin A4
UniProt Synonym Protein Names
35-beta calcimedin; Annexin IV; Annexin-4; Carbohydrate-binding protein p33/p41; Chromobindin-4; Endonexin I; Lipocortin IV; P32.5; PP4-X; Placental anticoagulant protein II; PAP-II; Protein II
Protein Family
Annexin
UniProt Gene Name
ANXA4
UniProt Synonym Gene Names
ANX4; PAP-II
NCBI Protein Information
annexin A4

NCBI Summary for ANXA4

Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]
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UniProt Comments for ANXA4

ANXA4: a calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Calcium-binding; Lipid-binding

Chromosomal Location of Human Ortholog: 2p13.3

Cellular Component: cell surface; cytoplasm; extracellular exosome; nuclear membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; vesicle membrane

Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; identical protein binding; NF-kappaB binding; phospholipase inhibitor activity; protein binding

Biological Process: epithelial cell differentiation; negative regulation of apoptosis; negative regulation of catalytic activity; negative regulation of interleukin-8 secretion; negative regulation of NF-kappaB transcription factor activity; Notch signaling pathway; regulation of transcription from RNA polymerase II promoter; signal transduction
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Research Articles on ANXA4

1. Study identifies ANXA4 and FLNA as up-regulated in buccal squamous cell carcinoma arising from oral submucous fibrosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ANXA4 antibody

 Products by Pathway  Pathway Diagram
 Prostaglandin Synthesis And Regulation Pathway antibodies  Prostaglandin Synthesis And Regulation Pathway Diagram

Diseases associated with anti-ANXA4 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >6 publications with ANXA4 and Carcinoma
 Neoplasms, Experimental Antibodies  >1 publications with ANXA4 and Neoplasms, Experimental
 Lung Diseases Antibodies  >1 publications with ANXA4 and Lung Diseases
 Lung Neoplasms Antibodies  >1 publications with ANXA4 and Lung Neoplasms
 Disease Models, Animal Antibodies  >1 publications with ANXA4 and Disease Models, Animal
 Hyperplasia Antibodies  >1 publications with ANXA4 and Hyperplasia
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with ANXA4 and Drug-Related Side Effects and Adverse Reactions
 Inflammation Antibodies  >1 publications with ANXA4 and Inflammation
 Necrosis Antibodies  >1 publications with ANXA4 and Necrosis
 Prostatic Neoplasms Antibodies  >1 publications with ANXA4 and Prostatic Neoplasms

Organs/Tissues associated with anti-ANXA4 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with ANXA4 and Blood
 Kidney Antibodies  >3 publications with ANXA4 and Kidney
 Stomach Antibodies  >2 publications with ANXA4 and Stomach
 Liver Antibodies  >2 publications with ANXA4 and Liver
 Uterus Antibodies  >2 publications with ANXA4 and Uterus
 Lung Antibodies  >2 publications with ANXA4 and Lung
 Intestine Antibodies  >2 publications with ANXA4 and Intestine
 Bladder Antibodies  >1 publications with ANXA4 and Bladder
 Pancreas Antibodies  >1 publications with ANXA4 and Pancreas
 Embryonic Tissue Antibodies  >1 publications with ANXA4 and Embryonic Tissue
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