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Alpha-1-Microglobulin/Bikunin Precursor (a1M) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2001596
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MBS2001596 is an antibody targeting a1M. Also known as Polyclonal Antibody to Alpha-1-Microglobulin/Bikunin Precursor (a1M). Reactive in Human. Host: Rabbit. More details

$205 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Alpha-1-Microglobulin/Bikunin Precursor (a1M), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Alpha-1-Microglobulin/Bikunin Precursor (a1M)
Product Gene Name
anti-a1M antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
0.46mg/ml (lot specific)
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 24 months.

Stability Test:
thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: a1M (MBS2001596)
Biotin Conjugated Antibody: a1M (MBS2004721)
Matching Pairs
Unconjugated Antibody: a1M (MBS2001596)
Immunogen: a1M (MBS2009321)
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OMIM
X04225 mRNA
3D Structure
ModBase 3D Structure for P02760
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Polyclonal antibody preparation
Traits
Liquid
Immunogen
Recombinant a1M (Val22~Val203) expressed in E.coli ( MBS2009321 ).
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-a1M antibody
Western Blot (WB); Immunohistochemistry (IHC); Immunocytochemistry (ICC); Immunoprecipitation (IP).
Application Notes for anti-a1M antibody
Western blotting: 0.01-2ug/mL
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-a1M antibody

Western Blot: Sample: Human Serum; Primary Ab: 2ug/ml Rabbit Anti-Human a1M Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;(Catalog: MBS2086047 )
Rabbit Anti-a1M Polyclonal Antibody – Cat# MBS2001596

Western Blot (WB) of anti-a1M antibody

Western Blot: Sample: Recombinant a1M, Human.
Rabbit Anti-a1M Polyclonal Antibody, Western Blot (WB) – Cat# MBS2001596

Other Notes

Small volumes of anti-a1M antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for a1M. It may not necessarily be applicable to this product.

NCBI GI #
4502067
NCBI GeneID
259
NCBI Accession #
NP_001624.1
UniProt Primary Accession #
P02760
UniProt Secondary Accession #
P00977; P02759; P78491; Q2TU33; Q5TBD7; Q9UC58; Q9UDI8
UniProt Related Accession #
P02760
GenBank Nucleotide #
NM_001633.3
NCBI Official Full Name
protein AMBP preproprotein
NCBI Official Synonym Full Names
alpha-1-microglobulin/bikunin precursor
NCBI Official Symbol
AMBP
NCBI Official Synonym Symbols
A1M; HCP; ITI; UTI; EDC1; HI30; ITIL; IATIL; ITILC
UniProt Protein Name
Protein AMBP
UniProt Synonym Protein Names
Alpha-1-microglobulin; Protein HC
Protein Family
Alpha-1-macroglobulin
UniProt Gene Name
AMBP
UniProt Synonym Gene Names
HCP; ITIL; Protein HC; ITI-LC
NCBI Protein Information
protein AMBP

NCBI Summary for a1M

This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq, Jul 2008]
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UniProt Comments for a1M

AMBP: Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q32

Cellular Component: cell surface; extracellular matrix; extracellular region; extracellular space; intracellular membrane-bound organelle; plasma membrane

Molecular Function: calcium channel inhibitor activity; calcium oxalate binding; heme binding; IgA binding; protein binding; protein homodimerization activity; serine-type endopeptidase inhibitor activity

Biological Process: cell adhesion; female pregnancy; heme catabolic process; negative regulation of immune response; negative regulation of JNK cascade; protein catabolic process; protein-chromophore linkage; receptor-mediated endocytosis; viral process
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Research Articles on a1M

1. There were significantly higher serum concentrations of fetal hemoglobin and alpha1-microglobulin and significantly lower first trimester serum concentrations of hemopexin in patients who later developed preeclampsia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-a1M antibody

 Reference Product  PubMed Publications
 APOA1 antibody  >2 publications with a1M and APOA1
 SERPINC1 antibody  >2 publications with a1M and SERPINC1
 AHSG antibody  >2 publications with a1M and AHSG
 ALB antibody  >2 publications with a1M and ALB
 FGG antibody  >1 publications with a1M and FGG
 ITIH3 antibody  >1 publications with a1M and ITIH3
 ITIH2 antibody  >1 publications with a1M and ITIH2

Pathways associated with anti-a1M antibody

 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Scavenging Of Heme From Plasma Pathway antibodies  Scavenging Of Heme From Plasma Pathway Diagram

Diseases associated with anti-a1M antibody

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >45 publications with a1M and Hypertension
 Inflammation Antibodies  >22 publications with a1M and Inflammation
 Necrosis Antibodies  >16 publications with a1M and Necrosis
 Kidney Diseases Antibodies  >12 publications with a1M and Kidney Diseases
 Heart Diseases Antibodies  >12 publications with a1M and Heart Diseases
 Hemorrhage Antibodies  >9 publications with a1M and Hemorrhage
 Liver Diseases Antibodies  >7 publications with a1M and Liver Diseases
 Drug-Induced Liver Injury Antibodies  >6 publications with a1M and Drug-Induced Liver Injury
 Disease Models, Animal Antibodies  >5 publications with a1M and Disease Models, Animal
 Hypertrophy Antibodies  >3 publications with a1M and Hypertrophy

Organs/Tissues associated with anti-a1M antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >35 publications with a1M and Heart
 Liver Antibodies  >29 publications with a1M and Liver
 Kidney Antibodies  >22 publications with a1M and Kidney
 Intestine Antibodies  >14 publications with a1M and Intestine
 Brain Antibodies  >13 publications with a1M and Brain
 Muscle Antibodies  >6 publications with a1M and Muscle
 Lung Antibodies  >5 publications with a1M and Lung
 Pancreas Antibodies  >3 publications with a1M and Pancreas
 Embryonic Tissue Antibodies  >2 publications with a1M and Embryonic Tissue
 Spleen Antibodies  >1 publications with a1M and Spleen
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