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Leukemia Inhibitory Factor Receptor (LIFR) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002307
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MBS2002307 is an antibody targeting LIFR. Also known as Polyclonal Antibody to Leukemia Inhibitory Factor Receptor (LIFR). Reactive in Mouse, Rat. Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Leukemia Inhibitory Factor Receptor (LIFR), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Leukemia Inhibitory Factor Receptor (LIFR)
Product Gene Name
anti-LIFR antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
0.55mg/ml (lot specific)
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 12 months.

Stability Test:
thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: LIFR (MBS2002307)
Immunogen: LIFR (MBS2011713)
Matching Pairs
Unconjugated Antibody: LIFR (MBS2002307)
APC-CY7 Conjugated Antibody: LIFR (MBS2044143)
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Molecular Weight
122,394 Da
3D Structure
ModBase 3D Structure for O70535
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Polyclonal antibody preparation
Traits
Liquid
Cross Reactivity
Mouse
Immunogen
Recombinant LIFR (Glu382~Ser486 (Accession # O70535)) expressed in E.coli (MBS2011713).
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-LIFR antibody
Western Blot (WB), Immunohistochemistry (IHC) Formalin/Paraffin, Immunocytochemistry (ICC), Immunoprecipitation (IP)
Application Notes for anti-LIFR antibody
Western blotting: 0.5-2ug/mL
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-LIFR antibody

Sample: Recombinant LIFR, Rat.
Rabbit Anti-LIFR Polyclonal Antibody – Cat# MBS2002307

Western Blot (WB) of anti-LIFR antibody

Sample: Rat Serum;
Primary Ab: 1ug/ml Rabbit Anti-Rat LIFR Antibody
Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-LIFR Polyclonal Antibody, Western Blot (WB) – Cat# MBS2002307

Immunohistochemistry (IHC) of anti-LIFR antibody

DAB staining on fromalin fixed paraffin- embedded kidney tissue)
Rabbit Anti-LIFR Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002307

Immunohistochemistry (IHC) of anti-LIFR antibody

DAB staining on IHC-P;
Samples: Rat Kidney Tissue)
Rabbit Anti-LIFR Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002307

Immunohistochemistry (IHC) of anti-LIFR antibody

DAB staining on IHC-P;
Samples: Rat Stomach Tissue;
Primary Ab: 10ug/ml Rabbit Anti-Rat LIFR Antibody
Second Ab: 2ug/mL HRP-Linked CaprineAnti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-LIFR Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002307

Other Notes

Small volumes of anti-LIFR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LIFR. It may not necessarily be applicable to this product.

NCBI GI #
13591979
NCBI GeneID
81680
NCBI Accession #
NP_112310.1
UniProt Primary Accession #
O70535
UniProt Related Accession #
O70535
GenBank Nucleotide #
NM_031048.1
NCBI Official Full Name
leukemia inhibitory factor receptor
NCBI Official Synonym Full Names
LIF receptor alpha
NCBI Official Symbol
Lifr
UniProt Protein Name
Leukemia inhibitory factor receptor
UniProt Synonym Protein Names
CD_antigen: CD118
Protein Family
Leukemia inhibitory factor receptor
UniProt Gene Name
Lifr
UniProt Synonym Gene Names
LIF receptor; LIF-R
NCBI Protein Information
leukemia inhibitory factor receptor

NCBI Summary for LIFR

alpha chain of leukemia inhibitory factor glycoprotein and growth factor [RGD, Feb 2006]

UniProt Comments for LIFR

LIFR: Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells (By similarity)

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 2q16

Cellular Component: extracellular space; integral component of membrane; plasma membrane; receptor complex

Molecular Function: ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding; cytokine binding; growth factor binding; leukemia inhibitory factor receptor activity; oncostatin-M receptor activity; protein binding; protein heterodimerization activity

Biological Process: cytokine-mediated signaling pathway; leukemia inhibitory factor signaling pathway; neuron projection morphogenesis; organ regeneration; positive regulation of cell proliferation; response to cytokine; response to organic cyclic compound
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Research Articles on LIFR

1. In the chronic kidney disease-cardiac hypertrophy model exercise rescues cardiac disease via cardiotrophin-1/LIFR/gp 130/JAK/STAT3 pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LIFR antibody

 Reference Product  PubMed Publications
 Lif antibody  >476 publications with LIFR and Lif
 Osm antibody  >399 publications with LIFR and Osm
 Il6st antibody  >125 publications with LIFR and Il6st
 Cntfr antibody  >44 publications with LIFR and Cntfr
 Il11 antibody  >23 publications with LIFR and Il11

Pathways associated with anti-LIFR antibody

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL-6-type Cytokine Receptor Ligand Interactions Pathway antibodies  IL-6-type Cytokine Receptor Ligand Interactions Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-6 Family Signaling Pathway antibodies  Interleukin-6 Family Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Signaling By Interleukins Pathway antibodies  Signaling By Interleukins Pathway Diagram

Diseases associated with anti-LIFR antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >41 publications with LIFR and Nervous System Diseases
 Inflammation Antibodies  >37 publications with LIFR and Inflammation
 Cardiovascular Diseases Antibodies  >25 publications with LIFR and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >23 publications with LIFR and Disease Models, Animal
 Liver Diseases Antibodies  >22 publications with LIFR and Liver Diseases
 Necrosis Antibodies  >21 publications with LIFR and Necrosis
 Adenocarcinoma Antibodies  >16 publications with LIFR and Adenocarcinoma
 Hypertrophy Antibodies  >16 publications with LIFR and Hypertrophy
 Stuve-Wiedemann syndrome Antibodies  >14 publications with LIFR and Stuve-Wiedemann syndrome
 Heart Diseases Antibodies  >12 publications with LIFR and Heart Diseases

Organs/Tissues associated with anti-LIFR antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >25 publications with LIFR and Heart
 Colon Antibodies  >3 publications with LIFR and Colon
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