Human STAT3 cDNA Clone Expression Plasmid – Cat# MBS1266595

STAT3 cDNA Clone – Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (Human)

Name: STAT3 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1266595
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1266595

MBS1266595 is a cDNA clone targeting STAT3. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

STAT3, cDNA Clone

Full Product Name

STAT3 cDNA Clone

Product Gene Name

STAT3 cdna clone

Sequence

atggcccaat ggaatcagct acagcagctt gacacacggt acctggagca gctccatcag ctctacagtg acagcttccc aatggagctg cggcagtttc tggccccttg gattgagagt caagattggg catatgcggc cagcaaagaa tcacatgcca ctttggtgtt tcataatctc ctgggagaga ttgaccagca gtatagccgc ttcctgcaag agtcgaatgt tctctatcag cacaatctac gaagaatcaa gcagtttctt cagagcaggt atcttgagaa gccaatggag attgcccgga ttgtggcccg gtgcctgtgg gaagaatcac gccttctaca gactgcagcc actgcggccc agcaaggggg ccaggccaac caccccacag cagccgtggt gacggagaag cagcagatgc tggagcagca ccttcaggat gtccggaaga gagtgcagga tctagaacag aaaatgaaag tggtagagaa tctccaggat gactttgatt tcaactataa aaccctcaag agtcaaggag acatgcaaga tctgaatgga aacaaccagt cagtgaccag gcagaagatg cagcagctgg aacagatgct cactgcgctg gaccagatgc ggagaagcat cgtgagtgag ctggcggggc ttttgtcagc gatggagtac gtgcagaaaa ctctcacgga cgaggagctg gctgactgga agaggcggca acagattgcc tgcattggag gcccgcccaa catctgccta gatcggctag aaaactggat aacgtcatta gcagaatctc aacttcagac ccgtcaacaa attaagaaac tggaggagtt gcagcaaaaa gtttcctaca aaggggaccc cattgtacag caccggccga tgctggagga gagaatcgtg gagctgttta gaaacttaat gaaaagtgcc tttgtggtgg agcggcagcc ctgcatgccc atgcatcctg accggcccct cgtcatcaag accggcgtcc agttcactac taaagtcagg ttgctggtca aattccctga gttgaattat cagcttaaaa ttaaagtgtg cattgacaaa gactctgggg acgttgcagc tctcagagga tcccggaaat ttaacattct gggcacaaac acaaaagtga tgaacatgga agaatccaac aacggcagcc tctctgcaga attcaaacac ttgaccctga gggagcagag atgtgggaat gggggccgag ccaattgtga tgcttccctg attgtgactg aggagctgca cctgatcacc tttgagaccg aggtgtatca ccaaggcctc aagattgacc tagagaccca ctccttgcca gttgtggtga tctccaacat ctgtcagatg ccaaatgcct gggcgtccat cctgtggtac aacatgctga ccaacaatcc caagaatgta aactttttta ccaagccccc aattggaacc tgggatcaag tggccgaggt cctgagctgg cagttctcct ccaccaccaa gcgaggactg agcatcgagc agctgactac actggcagag aaactcttgg gacctggtgt gaattattca gggtgtcaga tcacatgggc taaattttgc aaagaaaaca tggctggcaa gggcttctcc ttctgggtct ggctggacaa tatcattgac cttgtgaaaa agtacatcct ggccctttgg aacgaagggt acatcatggg ctttatcagt aaggagcggg agcgggccat cttgagcact aagcctccag gcaccttcct gctaagattc agtgaaagca gcaaagaagg aggcgtcact ttcacttggg tggagaagga catcagcggt aagacccaga tccagtccgt ggaaccatac acaaagcagc agctgaacaa catgtcattt gctgaaatca tcatgggcta taagatcatg gatgctacca atatcctggt gtctccactg gtctatctct atcctgacat tcccaaggag gaggcattcg gaaagtattg tcggccagag agccaggagc atcctgaagc tgacccaggt agcgctgccc catacctgaa gaccaagttt atctgtgtga caccaacgac ctgcagcaat accattgacc tgccgatgtc cccccgcact ttagattcat tgatgcagtt tggaaataat ggtgaaggtg ctgaaccctc agcaggaggg cagtttgagt ccctcacctt tgacatggag ttgacctcgg agtgcgctac ctcccccatg tga

Molecular Weight

83,126 Da

OMIM

102582

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of STAT3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for STAT3. It may not necessarily be applicable to this product.

NCBI GI #

15680253

NCBI GeneID

6774

NCBI Accession #

BC014482

UniProt Secondary Accession #

O14916; Q9BW54; A8K7B8; K7ENL3

UniProt Related Accession #

P40763

NCBI Official Full Name

Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor), mRNA

NCBI Official Synonym Full Names

signal transducer and activator of transcription 3

NCBI Official Symbol

STAT3

NCBI Official Synonym Symbols

APRF; HIES; ADMIO; ADMIO1

UniProt Protein Name

Signal transducer and activator of transcription 3

UniProt Synonym Protein Names

Acute-phase response factor

Protein Family

Signal transducer and activator of transcription

UniProt Gene Name

STAT3

UniProt Entry Name

STAT3_HUMAN

NCBI Protein Information

signal transducer and activator of transcription 3

NCBI Summary for STAT3

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]

UniProt Comments for STAT3

STAT3: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Constitutively active in a number of human tumors. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.

Protein type: Transcription factor; Nuclear receptor co-regulator; DNA-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: cytoplasm; cytosol; nuclear chromatin; nucleoplasm; nucleus; plasma membrane

Molecular Function: chromatin DNA binding; DNA binding; identical protein binding; ligand-dependent nuclear receptor activity; protein binding; protein dimerization activity; protein kinase binding; protein phosphatase binding; signal transducer activity; transcription factor activity; transcription factor binding

Biological Process: astrocyte differentiation; cell motility; cellular response to hormone stimulus; eating behavior; eye photoreceptor cell differentiation; glucose homeostasis; intracellular receptor-mediated signaling pathway; JAK-STAT cascade; leptin-mediated signaling pathway; miRNA-mediated gene silencing, negative regulation of translation; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; nervous system development; phosphorylation; positive regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of Stat3 protein; protein import into nucleus; radial glial cell differentiation; regulation of cell cycle; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to estradiol stimulus; sexual reproduction; signal transduction; somatic stem cell maintenance; thermoregulation

Disease: Autoimmune Disease, Multisystem, Infantile-onset; Hyper-ige Recurrent Infection Syndrome, Autosomal Dominant

Research Articles on STAT3

1. found STAT3 could bind promoter region of TXNDC17 (-623 bp to -58 bp relative to the transcription start site (TSS)) for regulating its expression

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with STAT3 cdna clone

Products by Pathway	Pathway Diagram
AGE/RAGE Pathway antibodies	AGE/RAGE Pathway Diagram
Acute Myeloid Leukemia Pathway antibodies	Acute Myeloid Leukemia Pathway Diagram
Acute Myeloid Leukemia Pathway antibodies	Acute Myeloid Leukemia Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Androgen Receptor Signaling Pathway antibodies	Androgen Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
BDNF Signaling Pathway antibodies	BDNF Signaling Pathway Diagram
CXCR4-mediated Signaling Events Pathway antibodies	CXCR4-mediated Signaling Events Pathway Diagram

Diseases associated with STAT3 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>3323 publications with STAT3 and Neoplasms
Inflammation Antibodies	>1333 publications with STAT3 and Inflammation
Necrosis Antibodies	>655 publications with STAT3 and Necrosis
Adenocarcinoma Antibodies	>535 publications with STAT3 and Adenocarcinoma
Liver Diseases Antibodies	>504 publications with STAT3 and Liver Diseases
Neoplasms, Experimental Antibodies	>379 publications with STAT3 and Neoplasms, Experimental
Breast Neoplasms Antibodies	>379 publications with STAT3 and Breast Neoplasms
Liver Neoplasms Antibodies	>306 publications with STAT3 and Liver Neoplasms
Lung Neoplasms Antibodies	>265 publications with STAT3 and Lung Neoplasms
Neoplasm Metastasis Antibodies	>235 publications with STAT3 and Neoplasm Metastasis

Organs/Tissues associated with STAT3 cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>2220 publications with STAT3 and Blood
Liver Antibodies	>1070 publications with STAT3 and Liver
Brain Antibodies	>874 publications with STAT3 and Brain
Vascular Antibodies	>790 publications with STAT3 and Vascular
Muscle Antibodies	>661 publications with STAT3 and Muscle
Lung Antibodies	>619 publications with STAT3 and Lung
Bone Antibodies	>609 publications with STAT3 and Bone
Heart Antibodies	>465 publications with STAT3 and Heart
Bone Marrow Antibodies	>403 publications with STAT3 and Bone Marrow
Skin Antibodies	>402 publications with STAT3 and Skin