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Pleiotrophin (PTN) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002309
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MBS2002309 is an antibody targeting PTN. Also known as Polyclonal Antibody to Pleiotrophin (PTN). Reactive in Mouse, Human, Rat. Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Pleiotrophin (PTN), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Pleiotrophin (PTN)
Product Gene Name
anti-PTN antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Human, Rat
Form/Format
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Purity/Purification
Antigen-specific Affinity Chromatography
Concentration
500ug/ml (lot specific)
Specificity
The antibody is a Rabbit polyclonal antibody raised against PTN. It has been selected for its ability to recognize PTN in immunohistochemical staining and western blotting.
Preparation and Storage
Storage: Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: PTN (MBS2002309)
Biotin Conjugated Antibody: PTN (MBS2002935)
Matching Pairs
Unconjugated Antibody: PTN (MBS2002309)
Immunogen: PTN (MBS2009179)
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Molecular Weight
18,869 Da
3D Structure
ModBase 3D Structure for P63089
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Polyclonal antibody preparation
Traits
Liquid
Immunogen
Recombinant PTN (Gly33~Asp168) expressed in E.coli
Cross Reactivity
Mouse
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2053736
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-PTN antibody
WB; IHC; ICC; IP
Application Notes for anti-PTN antibody
Western blotting: 0.5-2µg/mL
Immunohistochemistry: 5-20µg/mL
Immunocytochemistry: 5-20µg/mL

Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-PTN antibody

Western Blot: Sample: Mouse Brain Tissue.
Rabbit Anti-PTN Polyclonal Antibody – Cat# MBS2002309

Western Blot (WB) of anti-PTN antibody

Western Blot: Sample: Recombinant PTN, Mouse.
Rabbit Anti-PTN Polyclonal Antibody, Western Blot (WB) – Cat# MBS2002309

Immunohistochemistry (IHC) of anti-PTN antibody

DAB staining on IHC-P. Samples: Mouse Tissue)
Rabbit Anti-PTN Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002309

Other Notes

Small volumes of anti-PTN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PTN. It may not necessarily be applicable to this product.

NCBI GI #
6679543
NCBI GeneID
19242
NCBI Accession #
NP_032999.1
UniProt Primary Accession #
P63089
UniProt Secondary Accession #
P20935
UniProt Related Accession #
P63089
GenBank Nucleotide #
NM_008973.2
NCBI Official Full Name
pleiotrophin
NCBI Official Synonym Full Names
pleiotrophin
NCBI Official Symbol
Ptn
NCBI Official Synonym Symbols
OSF; HARP; HBBN; HBNF; Osf1; Osf-1; HB-GAM; HBGF-8
UniProt Protein Name
Pleiotrophin
UniProt Synonym Protein Names
Heparin-binding brain mitogen; HBBM; Heparin-binding growth factor 8; HBGF-8; Heparin-binding growth-associated molecule; HB-GAM; Heparin-binding neutrophic factor; HBNF; Osteoblast-specific factor 1; OSF-1
Protein Family
Pleiotrophin
UniProt Gene Name
Ptn
UniProt Synonym Gene Names
PTN; HBBM; HBGF-8; HB-GAM; HBNF; OSF-1
NCBI Protein Information
pleiotrophin

UniProt Comments for PTN

PTN: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation. Belongs to the pleiotrophin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6 B1|6 15.48 cM

Cellular Component: basement membrane; cell surface; cytoplasm; endoplasmic reticulum; extracellular region; extracellular space; membrane; neuromuscular junction; perinuclear region of cytoplasm; protein complex; proteinaceous extracellular matrix

Molecular Function: glycosaminoglycan binding; growth factor activity; heparin binding; protein kinase binding; proteoglycan binding

Biological Process: bone mineralization; learning; negative regulation of angiogenesis; negative regulation of cell migration; negative regulation of epithelial cell proliferation; negative regulation of membrane potential; ossification; positive regulation of apoptosis; positive regulation of cell division; positive regulation of cell proliferation; regulation of cell shape
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Research Articles on PTN

1. Ptn may play a vital role in the progesterone-induced decidualization pathway via C/EBPB-cyclic AMP-Hand2 signaling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTN antibody

 Reference Product  PubMed Publications
 Alk antibody  >26 publications with PTN and Alk
 Ptprz1 antibody  >22 publications with PTN and Ptprz1
 Sdc3 antibody  >7 publications with PTN and Sdc3
 Src antibody  >6 publications with PTN and Src
 Fyn antibody  >4 publications with PTN and Fyn
 Runx2 antibody  >3 publications with PTN and Runx2
 Fgfr1 antibody  >2 publications with PTN and Fgfr1
 Kdr antibody  >2 publications with PTN and Kdr
 Cspg5 antibody  >1 publications with PTN and Cspg5

Diseases associated with anti-PTN antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >117 publications with PTN and Nervous System Diseases
 Carcinoma Antibodies  >72 publications with PTN and Carcinoma
 Adenocarcinoma Antibodies  >35 publications with PTN and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >35 publications with PTN and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >34 publications with PTN and Disease Models, Animal
 Breast Neoplasms Antibodies  >25 publications with PTN and Breast Neoplasms
 Lung Neoplasms Antibodies  >24 publications with PTN and Lung Neoplasms
 Inflammation Antibodies  >23 publications with PTN and Inflammation
 Neoplasms, Experimental Antibodies  >17 publications with PTN and Neoplasms, Experimental
 Necrosis Antibodies  >16 publications with PTN and Necrosis

Organs/Tissues associated with anti-PTN antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >215 publications with PTN and Brain
 Spinal Cord Antibodies  >83 publications with PTN and Spinal Cord
 Bone Antibodies  >77 publications with PTN and Bone
 Muscle Antibodies  >63 publications with PTN and Muscle
 Embryonic Tissue Antibodies  >35 publications with PTN and Embryonic Tissue
 Lymph Node Antibodies  >30 publications with PTN and Lymph Node
 Lung Antibodies  >27 publications with PTN and Lung
 Heart Antibodies  >25 publications with PTN and Heart
 Liver Antibodies  >24 publications with PTN and Liver
 Kidney Antibodies  >22 publications with PTN and Kidney
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