Toll Interacting Protein (TOLLIP) Antibody – Rabbit Polyclonal

This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

TOLLIP: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Oligomerizes. Binds to TLR2 and the TLR4-MD2 complex via its C-terminus. Exists as complex with IRAK1 in unstimulated cells. Upon IL-1 signaling, Tollip binds to the activated IL-1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. Interacts with TOM1L2. Belongs to the tollip family.

Protein type: Inhibitor; Vesicle

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: cytoplasm; cytosol; extracellular region; interleukin-1 receptor complex; interleukin-18 receptor complex; nuclear body; perinuclear region of cytoplasm

Molecular Function: interleukin-1, Type I receptor binding; kinase binding; protein binding; signal transducer activity; SUMO binding; ubiquitin binding; ubiquitin conjugating enzyme binding; ubiquitin protein ligase binding

Biological Process: autophagy; cell-cell signaling; epithelial cell differentiation; inflammatory response; innate immune response; leukocyte activation; neutrophil degranulation; phosphorylation; positive regulation of protein sumoylation; signal transduction; ubiquitin-dependent protein catabolic process