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PGAM5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7050831

Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase… More details

$230 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PGAM5, Polyclonal Antibody
Full Product Name
PGAM5 Antibody
Product Gene Name
anti-PGAM5 antibody
Product Synonym Names
Serine/threonine-protein phosphatase PGAM5; mitochondrial; Bcl-XL-binding protein v68; Phosphoglycerate mutase family member 5; PGAM5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
>95%, Protein G purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: PGAM5 (MBS7050831)
HRP Conjugated Antibody: PGAM5 (MBS7050832)
Matching Pairs
Unconjugated Antibody: PGAM5 (MBS7050831)
FITC Conjugated Antibody: PGAM5 (MBS7050833)
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Molecular Weight
28,020 Da
OMIM
EU249757 mRNA
3D Structure
ModBase 3D Structure for Q96HS1
Immunogen
Recombinant human Serine/threonine-protein phosphatase PGAM5, mitochondrial protein (30-223AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, PH 7.4
Conjugation
Non-conjugated
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-161155 / sc-161156 / sc-161157
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PGAM5 antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-PGAM5 antibody
IHC: 1: 20-1: 200
IF: 1: 50-1: 200

Immunohistochemistry (IHC) of anti-PGAM5 antibody

Immunohistochemistry of paraffin-embedded human placenta tissue at dilution of 1:100
Rabbit Anti-PGAM5 Polyclonal Antibody – Cat# MBS7050831

Immunohistochemistry (IHC) of anti-PGAM5 antibody

Immunohistochemistry of paraffin-embedded human colon cancer at dilution of 1:100
Rabbit Anti-PGAM5 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS7050831

Immunohistochemistry (IHC) of anti-PGAM5 antibody

Immunofluorescent analysis of Hela cells at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Rabbit Anti-PGAM5 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS7050831

Other Notes

Small volumes of anti-PGAM5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PGAM5 purchase

MBS7050831 is an antibody targeting PGAM5. Also known as PGAM5 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PGAM5. It may not necessarily be applicable to this product.

NCBI GI #
281604136
NCBI GeneID
192111
NCBI Accession #
NP_001164014.1
UniProt Primary Accession #
Q96HS1
UniProt Secondary Accession #
Q96JB0; A9LN06; C9IZY7
UniProt Related Accession #
Q96HS1
GenBank Nucleotide #
NM_001170543.1
NCBI Official Full Name
serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 1
NCBI Official Synonym Full Names
PGAM family member 5, mitochondrial serine/threonine protein phosphatase
NCBI Official Symbol
PGAM5
NCBI Official Synonym Symbols
BXLBV68
UniProt Protein Name
Serine/threonine-protein phosphatase PGAM5, mitochondrial
UniProt Synonym Protein Names
Bcl-XL-binding protein v68; Phosphoglycerate mutase family member 5
Protein Family
Serine/threonine-protein phosphatase
UniProt Gene Name
PGAM5
UniProt Entry Name
PGAM5_HUMAN
NCBI Protein Information
serine/threonine-protein phosphatase PGAM5, mitochondrial

UniProt Comments for PGAM5

PGAM5: Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.16; Hydrolase; Membrane protein, integral; Mitochondrial

Chromosomal Location of Human Ortholog: 12q24.33

Cellular Component: mitochondrion

Molecular Function: GTPase activator activity; phosphoric monoester hydrolase activity; protein complex binding; receptor signaling protein serine/threonine phosphatase activity
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Research Articles on PGAM5

1. Results indicate that a multiprotein complex including PGAM5, Bax and Drp1 proteins specifically formed during intrinsic apoptosis induction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PGAM5 antibody

 Reference Product  PubMed Publications
 MLKL antibody  >11 publications with PGAM5 and MLKL
 PINK1 antibody  >8 publications with PGAM5 and PINK1
 KEAP1 antibody  >6 publications with PGAM5 and KEAP1
 DNM1L antibody  >5 publications with PGAM5 and DNM1L

Pathways associated with anti-PGAM5 antibody

 Products by Pathway  Pathway Diagram
 TNF Signaling Pathway antibodies  TNF Signaling Pathway Diagram
 TNF Signaling Pathway antibodies  TNF Signaling Pathway Diagram

Diseases associated with anti-PGAM5 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >15 publications with PGAM5 and Necrosis
 Inflammation Antibodies  >9 publications with PGAM5 and Inflammation
 Nervous System Diseases Antibodies  >4 publications with PGAM5 and Nervous System Diseases
 Disease Models, Animal Antibodies  >3 publications with PGAM5 and Disease Models, Animal
 Hepatitis Antibodies  >3 publications with PGAM5 and Hepatitis
 Prostatic Diseases Antibodies  >1 publications with PGAM5 and Prostatic Diseases
 Liver Diseases Antibodies  >1 publications with PGAM5 and Liver Diseases
 Fatty Liver Antibodies  >1 publications with PGAM5 and Fatty Liver
 Genital Diseases, Male Antibodies  >1 publications with PGAM5 and Genital Diseases, Male
 Cell Transformation, Neoplastic Antibodies  >1 publications with PGAM5 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-PGAM5 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >5 publications with PGAM5 and Liver
 Brain Antibodies  >3 publications with PGAM5 and Brain
 Bone Antibodies  >2 publications with PGAM5 and Bone
 Lung Antibodies  >2 publications with PGAM5 and Lung
 Muscle Antibodies  >1 publications with PGAM5 and Muscle
 Bladder Antibodies  >1 publications with PGAM5 and Bladder
 Prostate Antibodies  >1 publications with PGAM5 and Prostate
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