Axis Inhibition Protein 2 (AXIN2) Antibody – Rabbit Polyclonal

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]

axin 2: is a negative regulator of the Wnt pathway, which is critical in stem cell signaling, morphogenesis, the mesenchymal-epithelial transition, and many cancers. Axin functions as a tumor suppressor. Probably facilitates the phosphorylation of beta-catenin and APC by GSK3B, leading to their ubiquitination and subsequent proteolysis. Is downregulated during progression of esophageal squamous cell carcinoma. Axin1/2 mediate cross-talk between TGF-beta and Wnt signaling pathways.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17q24.1

Cellular Component: beta-catenin destruction complex; centrosome; cytoplasm; cytosol; nucleus; plasma membrane

Molecular Function: beta-catenin binding; enzyme binding; GTPase activator activity; I-SMAD binding; protein binding; ubiquitin protein ligase binding

Biological Process: beta-catenin-TCF complex assembly; bone mineralization; cell proliferation; cellular protein localization; chondrocyte differentiation involved in endochondral bone morphogenesis; intramembranous ossification; maintenance of DNA repeat elements; mRNA stabilization; negative regulation of canonical Wnt signaling pathway; negative regulation of cell proliferation; negative regulation of osteoblast differentiation; odontogenesis; positive regulation of canonical Wnt signaling pathway; positive regulation of cell death; positive regulation of epithelial to mesenchymal transition; positive regulation of GTPase activity; positive regulation of protein phosphorylation; protein deubiquitination; regulation of mismatch repair; secondary heart field specification; somitogenesis; Wnt signaling pathway

Disease: Colorectal Cancer; Oligodontia-colorectal Cancer Syndrome