Endoglin (ENG) Antibody – Rabbit Polyclonal

ENG: Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. Interacts with ARRB2. Endoglin is restricted to endothelial cells in all tissues except bone marrow. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 2 B|2 22.09 cM

Cellular Component: cell surface; external side of plasma membrane; extracellular space; focal adhesion; integral component of membrane; membrane; receptor complex

Molecular Function: galactose binding; glycosaminoglycan binding; protein binding; protein homodimerization activity; transforming growth factor beta binding; transforming growth factor beta receptor, cytoplasmic mediator activity; transforming growth factor beta-activated receptor activity; type II transforming growth factor beta receptor binding

Biological Process: angiogenesis; artery morphogenesis; atrial cardiac muscle morphogenesis; branching involved in blood vessel morphogenesis; cell adhesion; cell migration; cell motility; central nervous system vasculogenesis; chronological cell aging; extracellular matrix disassembly; heart development; heart looping; negative regulation of cell migration; negative regulation of endothelial cell proliferation; negative regulation of nitric-oxide synthase activity; negative regulation of protein autophosphorylation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; positive regulation of collagen biosynthetic process; positive regulation of protein phosphorylation; positive regulation of systemic arterial blood pressure; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; regulation of transforming growth factor beta receptor signaling pathway; response to hypoxia; smooth muscle development; sprouting angiogenesis; transforming growth factor beta receptor signaling pathway; vasculogenesis; venous blood vessel morphogenesis; wound healing