Intercellular Adhesion Molecule 1 (ICAM1) Antibody – Rabbit Polyclonal

ICAM1: a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta.

Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cell surface; external side of plasma membrane; extracellular exosome; extracellular matrix; extracellular space; focal adhesion; immunological synapse; integral component of plasma membrane; membrane; membrane raft; plasma membrane

Molecular Function: integrin binding; protein binding; receptor activity; transmembrane receptor activity; viral receptor activity

Biological Process: acute inflammatory response to antigenic stimulus; adhesion of symbiont to host; cell adhesion; cell adhesion mediated by integrin; cell aging; cellular response to alkaloid; cellular response to dexamethasone stimulus; cellular response to glucose stimulus; cellular response to hypoxia; cellular response to interleukin-1; cellular response to interleukin-6; cellular response to nutrient levels; cellular response to tumor necrosis factor; entry of virus into host cell; establishment of endothelial intestinal barrier; extracellular matrix organization; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; leukocyte adhesion; leukocyte migration; membrane to membrane docking; negative regulation of calcium ion transport; negative regulation of endothelial cell apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; ovarian follicle development; positive regulation of actin filament polymerization; positive regulation of cellular extravasation; positive regulation of ERK1 and ERK2 cascade; positive regulation of GTPase activity; positive regulation of leukocyte adhesion to vascular endothelial cell; positive regulation of NF-kappaB transcription factor activity; positive regulation of nitric oxide biosynthetic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of vasoconstriction; receptor-mediated virion attachment to host cell; regulation of cell shape; regulation of immune response; regulation of leukocyte mediated cytotoxicity; regulation of ruffle assembly; response to amino acid; response to amphetamine; response to copper ion; response to drug; response to ethanol; response to gonadotropin; response to insulin stimulus; response to ionizing radiation; response to sulfur dioxide; sensory perception of sound; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; T cell antigen processing and presentation

Disease: Malaria, Susceptibility To