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Cluster of Differentiation (CD163) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002979
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MBS2002979 is an antibody targeting CD163. Also known as Polyclonal Antibody to Cluster Of Differentiation (CD163). Reactive in Mouse. Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cluster Of Differentiation (CD163), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Cluster Of Differentiation (CD163)
Product Gene Name
anti-CD163 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
0.61mg/ml (lot specific)
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 24 months.

Stability Test:
thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: CD163 (MBS2002979)
Immunogen: CD163 (MBS2011244)
Matching Pairs
Unconjugated Antibody: CD163 (MBS2002979)
APC-CY7 Conjugated Antibody: CD163 (MBS2058315)
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3D Structure
ModBase 3D Structure for Q2VLH6
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Organism Species
Mus musculus (Mouse)
Source
Polyclonal antibody preparation
Cross Reactivity
Mouse
Traits
Liquid
Immunogen
Recombinant CD163 (Pro697~Gly972) expressed in E.coli (MBS2011244).
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-CD163 antibody
Western Blot (WB); Immunohistochemistry (IHC); Immunocytochemsitry (ICC); Immunoprecipitation (IP).
Application Notes for anti-CD163 antibody
Western blotting: 0.5-2ug/mL
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-CD163 antibody

Western Blot; Sample: Recombinant CD163, Mouse.
Rabbit Anti-CD163 Polyclonal Antibody – Cat# MBS2002979

Immunohistochemistry (IHC) of anti-CD163 antibody

DAB staining on IHC-P;
Samples: Mouse Liver Tissue;
Primary Ab: 20ug/ml Rabbit Anti-Mouse CD163 Antibody
Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-CD163 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002979

Immunohistochemistry (IHC) of anti-CD163 antibody

DAB staining on IHC-P;
Samples: Mouse Stomach Tissue;
Primary Ab: 20ug/ml Rabbit Anti-Mouse CD163 Antibody
Second Ab: 2ug/mL HRP-Linked Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-CD163 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002979

Other Notes

Small volumes of anti-CD163 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CD163. It may not necessarily be applicable to this product.

NCBI GI #
281371421
NCBI GeneID
93671
NCBI Accession #
NP_444324.2
UniProt Primary Accession #
Q2VLH6
UniProt Secondary Accession #
Q2VLH5; Q99MX8; A6H691
UniProt Related Accession #
Q2VLH6
GenBank Nucleotide #
NM_053094.2
NCBI Official Full Name
scavenger receptor cysteine-rich type 1 protein M130 isoform 2
NCBI Official Synonym Full Names
CD163 antigen
NCBI Official Symbol
Cd163
NCBI Official Synonym Symbols
CD163v2; CD163v3
UniProt Protein Name
Scavenger receptor cysteine-rich type 1 protein M130
UniProt Synonym Protein Names
CD_antigen: CD163
Protein Family
Scavenger receptor cysteine-rich type 1 protein
UniProt Gene Name
Cd163
UniProt Synonym Gene Names
M130; sCD163
NCBI Protein Information
scavenger receptor cysteine-rich type 1 protein M130

UniProt Comments for CD163

CD163: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6|6 F2

Cellular Component: external side of plasma membrane; extracellular region; integral component of membrane; membrane; plasma membrane

Molecular Function: scavenger receptor activity

Biological Process: acute-phase response; inflammatory response
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Research Articles on CD163

1. house dust mite -challenged Cd163-/- mice displayed increases in airway eosinophils and mucous cell metaplasia

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD163 antibody

 Reference Product  PubMed Publications
 Cd68 antibody  >579 publications with CD163 and Cd68
 Il6 antibody  >30 publications with CD163 and Il6
 Cd36 antibody  >30 publications with CD163 and Cd36
 Il4 antibody  >13 publications with CD163 and Il4
 Csf1 antibody  >9 publications with CD163 and Csf1
 C1qb antibody  >1 publications with CD163 and C1qb
 Tac1 antibody  >1 publications with CD163 and Tac1

Pathways associated with anti-CD163 antibody

 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Macrophage Markers Pathway antibodies  Macrophage Markers Pathway Diagram
 Scavenging Of Heme From Plasma Pathway antibodies  Scavenging Of Heme From Plasma Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram

Diseases associated with anti-CD163 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >599 publications with CD163 and Inflammation
 Necrosis Antibodies  >236 publications with CD163 and Necrosis
 Cardiovascular Diseases Antibodies  >168 publications with CD163 and Cardiovascular Diseases
 Liver Diseases Antibodies  >97 publications with CD163 and Liver Diseases
 Fibrosis Antibodies  >94 publications with CD163 and Fibrosis
 Disease Models, Animal Antibodies  >93 publications with CD163 and Disease Models, Animal
 Lung Diseases Antibodies  >86 publications with CD163 and Lung Diseases
 Adenocarcinoma Antibodies  >63 publications with CD163 and Adenocarcinoma
 Heart Diseases Antibodies  >58 publications with CD163 and Heart Diseases
 Hepatitis Antibodies  >46 publications with CD163 and Hepatitis

Organs/Tissues associated with anti-CD163 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >165 publications with CD163 and Skin
 Brain Antibodies  >125 publications with CD163 and Brain
 Lymph Node Antibodies  >98 publications with CD163 and Lymph Node
 Joint Antibodies  >67 publications with CD163 and Joint
 Embryonic Tissue Antibodies  >31 publications with CD163 and Embryonic Tissue
 Bladder Antibodies  >7 publications with CD163 and Bladder
 Mammary Gland Antibodies  >3 publications with CD163 and Mammary Gland
 Vagina Antibodies  >2 publications with CD163 and Vagina
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