Heat Shock 70kDa Protein 8 (HSPA8) Antibody – Rabbit Polyclonal

HSC70: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co- chaperones. Interacts with HSPH1/HSP105. Interacts with IRAK1BP1. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with PACRG and TSC2. Interacts with BAG1. Interacts with SV40 VP1. Interacts with DNAJC7. Interacts with HERC5. Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation. Constitutively synthesized. Ubiquitous. Belongs to the heat shock protein 70 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Chaperone; Heat shock protein; Nucleolus; RNA-binding

Chromosomal Location of Human Ortholog: 8q22

Cellular Component: asymmetric synapse; autophagic vacuole; axon; cell soma; cell surface; cytoplasm; cytosol; dendrite; dendritic shaft; dendritic spine; extracellular matrix; extracellular space; focal adhesion; intermediate filament; intracellular; intracellular ribonucleoprotein complex; late endosome; lysosomal membrane; lysosome; melanosome; membrane; membrane raft; microtubule; myelin sheath; neuron projection; nucleolus; nucleus; perikaryon; perinuclear region of cytoplasm; photoreceptor inner segment; plasma membrane; postsynaptic density; protein complex; spliceosomal complex; synaptic vesicle; terminal bouton; ubiquitin ligase complex

Molecular Function: A1 adenosine receptor binding; ADP binding; ATP binding; ATPase activity; ATPase activity, coupled; cadherin binding; enzyme binding; G-protein coupled receptor binding; heat shock protein binding; peptide binding; phosphatidylserine binding; protein binding; receptor binding; RNA binding; transcription factor binding; ubiquitin protein ligase binding; unfolded protein binding

Biological Process: aging; ATP metabolic process; axon cargo transport; cellular protein complex disassembly; cerebellum development; chaperone cofactor-dependent protein folding; forebrain development; G1/S transition of mitotic cell cycle; kidney development; mRNA processing; negative regulation of transcription, DNA-dependent; positive regulation of catalytic activity; positive regulation of mRNA splicing, via spliceosome; positive regulation of phagocytosis; positive regulation of proteolysis; positive regulation of T cell mediated cytotoxicity; protein autophosphorylation; protein folding; protein import into nucleus; protein refolding; regulation of cell cycle; regulation of protein stability; response to activity; response to drug; response to estradiol; response to ethanol; response to heat; response to nickel ion; response to progesterone; response to starvation; RNA splicing; sensory perception of smell; skeletal muscle tissue development; synaptic vesicle uncoating; transcription, DNA-dependent