Human IMPDH2 cDNA Clone Expression Plasmid – Cat# MBS1273729

IMPDH2 cDNA Clone – IMP (Inosine Monophosphate) Dehydrogenase 2 (Human)

Name: IMPDH2 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1273729
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1273729

MBS1273729 is a cDNA clone targeting IMPDH2. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IMPDH2, cDNA Clone

Full Product Name

IMPDH2 cDNA Clone

Product Gene Name

IMPDH2 cdna clone

Sequence

atggccgact acctgattag tgggggcacg tcctacgtgc cagacgacgg actcacagca cagcagctct tcaactgcgg agacggcctc acctacaatg actttctcat tctccctggg tacatcgact tcactgcaga ccaggtggac ctgacttctg ctctgaccaa gaaaatcact cttaagaccc cactggtttc ctctcccatg gacacagtca cagaggctgg gatggccata gcaatggcgc ttacaggcgg tattggcttc atccaccaca actgtacacc tgaattccag gccaatgaag ttcggaaagt gaagaaatat gaacagggat tcatcacaga ccctgtggtc ctcagcccca aggatcgcgt gcgggatgtt tttgaggcca aggcccggca tggtttctgc ggtatcccaa tcacagacac aggccggatg gggagccgct tggtgggcat catctcctcc agggacattg attttctcaa agaggaggaa catgactgtt tcttggaaga gataatgaca aagagggaag acttggtggt agcccctgca ggcatcacac tgaaggaggc aaatgaaatt ctgcagcgca gcaagaaggg aaagttgccc attgtaaatg aagatgatga gcttgtggcc atcattgccc ggacagacct gaagaagaat cgggactacc cactagcctc caaagatgcc aagaaacagc tgctgtgtgg ggcagccatt ggcactcatg aggatgacaa gtataggctg gacttgctcg cccaggctgg tgtggatgta gtggttttgg actcttccca gggaaattcc atcttccaga tcaatatgat caagtacatc aaagacaaat accctaatct ccaagtcatt ggaggcaatg tggtcactgc tgcccaggcc aagaacctca ttgatgcagg tgtggatgcc ctgcgggtgg gcatgggaag tggctccatc tgcattacgc aggaagtgct ggcctgtggg cggccccaag caacagcagt gtacaaggtg tcagagtatg cacggcgctt tggtgttccg gtcattgctg atggaggaat ccaaaatgtg ggtcatattg cgaaagcctt ggcccttggg gcctccacag tcatgatggg ctctctcctg gctgccacca ctgaggcccc tggtgaatac ttcttttccg atgggatccg gctaaagaaa tatcgcggta tgggttctct cgatgccatg gacaagcacc tcagcagcca gaacagatat ttcagtgaag ctgacaaaat caaagtggcc cagggagtgt ctggtgctgt gcaggacaaa gggtcaatcc acaaatttgt cccttacctg attgctggca tccaacactc atgccaggac attggtgcca agagcttgac ccaagtccga gccatgatgt actctgggga gcttaagttt gagaagagaa cgtcctcagc ccaggtggaa ggtggcgtcc atagcctcca ttcgtatgag aagcggcttt tctga

Molecular Weight

55,805 Da

OMIM

146691

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of IMPDH2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IMPDH2. It may not necessarily be applicable to this product.

NCBI GI #

13543972

NCBI GeneID

3615

NCBI Accession #

BC006124

UniProt Secondary Accession #

Q6LEF3

UniProt Related Accession #

P12268

NCBI Official Full Name

Homo sapiens IMP (inosine monophosphate) dehydrogenase 2, mRNA

NCBI Official Synonym Full Names

inosine monophosphate dehydrogenase 2

NCBI Official Symbol

IMPDH2

NCBI Official Synonym Symbols

IMPD2; IMPDH-II

UniProt Protein Name

Inosine-5'-monophosphate dehydrogenase 2

UniProt Synonym Protein Names

IMPDH-II

UniProt Gene Name

IMPDH2

UniProt Synonym Gene Names

IMP dehydrogenase 2; IMPD 2; IMPDH 2

UniProt Entry Name

IMDH2_HUMAN

NCBI Protein Information

inosine-5'-monophosphate dehydrogenase 2

NCBI Summary for IMPDH2

This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]

UniProt Comments for IMPDH2

IMPDH2: a rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.

Protein type: EC 1.1.1.205; Nucleotide Metabolism - purine; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - other enzymes

Chromosomal Location of Human Ortholog: 3p21.2

Cellular Component: cytoplasm; cytosol; membrane; nucleus; peroxisomal membrane

Molecular Function: IMP dehydrogenase activity; nucleotide binding; protein binding

Biological Process: GTP biosynthetic process; purine ribonucleoside monophosphate biosynthetic process

Research Articles on IMPDH2

1. The findings suggest that overexpressed IMPDH2 can be used as a biomarker for kidney and bladder cancer diagnosis and is a potential therapeutic target for the diseases

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with IMPDH2 cdna clone

Products by Pathway	Pathway Diagram
Drug Metabolism - Other Enzymes Pathway antibodies	Drug Metabolism - Other Enzymes Pathway Diagram
Drug Metabolism - Other Enzymes Pathway antibodies	Drug Metabolism - Other Enzymes Pathway Diagram
Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies	Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies	Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Nucleotides Pathway antibodies	Metabolism Of Nucleotides Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Ribonucleoside Monophosphate Biosynthesis Pathway antibodies	Purine Ribonucleoside Monophosphate Biosynthesis Pathway Diagram

Diseases associated with IMPDH2 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>15 publications with IMPDH2 and Neoplasms
Leukemia Antibodies	>3 publications with IMPDH2 and Leukemia
Drug Toxicity Antibodies	>3 publications with IMPDH2 and Drug Toxicity
Kidney Diseases Antibodies	>3 publications with IMPDH2 and Kidney Diseases
Inflammation Antibodies	>2 publications with IMPDH2 and Inflammation
Neoplasm Metastasis Antibodies	>2 publications with IMPDH2 and Neoplasm Metastasis
Carcinoma Antibodies	>2 publications with IMPDH2 and Carcinoma
Liver Diseases Antibodies	>2 publications with IMPDH2 and Liver Diseases
Nausea Antibodies	>1 publications with IMPDH2 and Nausea
Fibrosis Antibodies	>1 publications with IMPDH2 and Fibrosis

Organs/Tissues associated with IMPDH2 cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>16 publications with IMPDH2 and Blood
Kidney Antibodies	>15 publications with IMPDH2 and Kidney
Liver Antibodies	>4 publications with IMPDH2 and Liver
Pancreas Antibodies	>2 publications with IMPDH2 and Pancreas
Heart Antibodies	>2 publications with IMPDH2 and Heart
Eye Antibodies	>2 publications with IMPDH2 and Eye
Bone Antibodies	>2 publications with IMPDH2 and Bone
Stomach Antibodies	>1 publications with IMPDH2 and Stomach
Prostate Antibodies	>1 publications with IMPDH2 and Prostate
Uterus Antibodies	>1 publications with IMPDH2 and Uterus