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RAC1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS201231

Rac is a subfamily of the Rho family of GTPases, small (~21 kDa) signaling G proteins (more specifically a GTPase). When bound to GTP, Rac is activated. In its activated state, Rac participates in the regulation of cell movement, through its involvement in… More details

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Product Overview

Online Datasheet in PDF
Product Name
Rac1,2,3, Monoclonal Antibody
Full Product Name
Rac1,2,3
Product Gene Name
anti-Rac1 antibody
Product Synonym Gene Name
Rac2, Rac3
Product Synonym Names
Ras-related C3 botulinum toxin substrate 1 isoform Rac1; RAC1; RAC1; p21-Rac1; Ras-like protein TC25; Cell migration-inducing gene 5 protein; Ras-related C3 botulinum toxin substrate 1; Ras-related C3 botulinum toxin substrate 1 isoform Rac1 MGC111543; MIG 5; MIG5; Migration inducing gene 5; Migration inducing protein 5; p21 Rac1; Rac 1; Ras like protein TC25; Ras related C3 botulinum toxin substrate 1; Rho family small GTP binding protein Rac1; TC 25; Ras-related C3 botulinum toxin substrate 2.; EN-7; Gx; HSPC022; Ras-related C3 botulinum toxin substrate 2; EN 7; EN7; HSPC 022; p21 Rac 2; p21 Rac2; p21Rac2; RAC 2; Ras related C3 botulinum toxin substrate 2; Ras related C3 botulinum toxin substrate 3; Rho family small GTP binding protein Rac 2; Rho family small GTP binding protein Rac2; Small G protein; as-related C3 botulinum toxin substrate 3; p21-Rac3; Rac1B; RAS related C3 botulinum substrate 3; Ras related C3 botulinum toxin substrate 3; rho family small GTP binding protein Rac3; Rho family small GTP binding protein Rac3; RP23-84C12.18
Clonality
Monoclonal
Isotype
IgG2b kappa
Clone Number
AT2G10
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol
Purity/Purification
By protein-A affinity chromatography
Concentration
1mg/ml (lot specific)
Preparation and Storage
Can be stored at 2 degree C to 8 degree C for 1 week. For long term storage, aliquot and store at -20 degree C to -80 degree C. Avoid repeated freezing and thawing cycles.
OMIM
602049
3D Structure
ModBase 3D Structure for P15153
Antigen Species
Human
Immunogen
Recombinant human RAC2 (1-189aa) protein purified from E. coli
Conjugation
Unconjugated

Product Categories/Family for anti-Rac1 antibody

Cancer; Epigenetics and Nuclear Signaling; Immunology; Signal Transduction
Applications Tested/Suitable for anti-Rac1 antibody
ELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-Rac1 antibody
The antibody has been tested by ELISA, Western blot and FACS analysis to assure specificity and reactivity.

Western Blot (WB) of anti-Rac1 antibody

The recombinant proteins (50ng) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human Rac1,2,3 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: Recombinant human Rac 1 protein Lane 2.: Recombinant human Rac 2 protein Lane 3.: Recombinant human Rac 3 protein
Mouse Anti-RAC1 Monoclonal Antibody – Cat# MBS201231

Flow Cytometry (FC/FACS) of anti-Rac1 antibody

Flow cytometry analysis of Rac1,2,3 in Jurkat cells. The cell was stained at 2-5ug for 1x10^6cells (red). A Goat anti mouse IgG (Alexa fluor 488) was used as the secondary antibody. Mouse monoclonal IgG was used as the isotype control (dark gray), cells without incubation with primary and secondary antibody was used as the negative control (light gray).
Mouse Anti-RAC1 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS201231

Product References and Citations for anti-Rac1 antibody

Ridley AJ. (2006). Trends Cell Biol. 16(10):522-529.; Maldonado MDM., et al. (2018). Cancer Res. 15; 78(12):3101-3111.

Other Notes

Small volumes of anti-Rac1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Rac1 purchase

MBS201231 is an antibody targeting Rac1. Also known as Rac1,2,3. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Rac1. It may not necessarily be applicable to this product.

NCBI GI #
4506381
NCBI GeneID
5880
NCBI Accession #
NP_002863
UniProt Primary Accession #
P15153
UniProt Related Accession #
P15153
GenBank Nucleotide #
NP_002863.1
NCBI Official Full Name
ras-related C3 botulinum toxin substrate 2
NCBI Official Synonym Full Names
Rac family small GTPase 2
NCBI Official Symbol
RAC2
NCBI Official Synonym Symbols
Gx; EN-7; HSPC022; p21-Rac2
UniProt Protein Name
Ras-related C3 botulinum toxin substrate 2
UniProt Synonym Protein Names
GX; Small G protein; p21-Rac2
Protein Family
Rac-like GTP-binding protein
UniProt Gene Name
RAC2
UniProt Entry Name
RAC2_HUMAN
NCBI Protein Information
ras-related C3 botulinum toxin substrate 2

NCBI Summary for Rac1

This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]
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Research Articles on Rac1

1. These results collectively suggest that Rac2 plays a critical, previously unrecognized, role in natural killer cell cytotoxicity

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Rac1 antibody

 Reference Product  PubMed Publications
 VAV1 antibody  >20 publications with Rac1 and VAV1
 TIAM1 antibody  >8 publications with Rac1 and TIAM1
 VAV2 antibody  >5 publications with Rac1 and VAV2
 NCF2 antibody  >4 publications with Rac1 and NCF2
 ARHGDIB antibody  >4 publications with Rac1 and ARHGDIB
 PAK2 antibody  >2 publications with Rac1 and PAK2
 ARHGDIA antibody  >2 publications with Rac1 and ARHGDIA

Pathways associated with anti-Rac1 antibody

 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram

Diseases associated with anti-Rac1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >50 publications with Rac1 and Neoplasms
 Inflammation Antibodies  >45 publications with Rac1 and Inflammation
 Neutrophil Immunodeficiency Syndrome Antibodies  >17 publications with Rac1 and Neutrophil Immunodeficiency Syndrome
 Disease Models, Animal Antibodies  >14 publications with Rac1 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >12 publications with Rac1 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >12 publications with Rac1 and Nervous System Diseases
 Lymphoma Antibodies  >9 publications with Rac1 and Lymphoma
 Necrosis Antibodies  >8 publications with Rac1 and Necrosis
 Carcinoma Antibodies  >7 publications with Rac1 and Carcinoma
 Anemia Antibodies  >6 publications with Rac1 and Anemia

Organs/Tissues associated with anti-Rac1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >261 publications with Rac1 and Blood
 Bone Antibodies  >71 publications with Rac1 and Bone
 Bone Marrow Antibodies  >64 publications with Rac1 and Bone Marrow
 Vascular Antibodies  >20 publications with Rac1 and Vascular
 Brain Antibodies  >14 publications with Rac1 and Brain
 Lung Antibodies  >13 publications with Rac1 and Lung
 Eye Antibodies  >11 publications with Rac1 and Eye
 Spleen Antibodies  >10 publications with Rac1 and Spleen
 Heart Antibodies  >8 publications with Rac1 and Heart
 Liver Antibodies  >7 publications with Rac1 and Liver
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