Transportin 2 (TNPO2) Antibody – Rabbit Polyclonal

TNPO2: Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the importin beta family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Karyopherin; Nuclear import

Chromosomal Location of Human Ortholog: 19p13.13

Cellular Component: cytoplasm; nuclear membrane; nucleus

Molecular Function: nuclear localization sequence binding; protein binding; protein transporter activity; Ran GTPase binding

Biological Process: NLS-bearing substrate import into nucleus; protein import into nucleus, translocation; ribosomal protein import into nucleus