Adenylate Cyclase 8 (ADCY8) Antibody – Rabbit Polyclonal

Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]

ADCY8: This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Protein type: Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family

Chromosomal Location of Human Ortholog: 8q24.22

Cellular Component: guanylate cyclase complex, soluble; integral component of membrane; membrane; plasma membrane

Molecular Function: adenylate cyclase activity; ATP binding; calcium- and calmodulin-responsive adenylate cyclase activity; guanylate cyclase activity; metal ion binding

Biological Process: activation of protein kinase A activity; adenylate cyclase activation; adenylate cyclase-activating G-protein coupled receptor signaling pathway; cAMP biosynthetic process; cGMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; learning and/or memory; long-term memory; renal water homeostasis; signal transduction