Stathmin 1 (STMN1) Antibody – Rabbit Polyclonal

This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

STMN1: a microtubule-associated protein involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Phosphorylation reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, nonleukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: cytoplasm; cytosol; extracellular exosome; intracellular; membrane; microtubule; neuron projection

Molecular Function: protein binding; signal transducer activity; tubulin binding

Biological Process: axonogenesis; brain development; hepatocyte growth factor receptor signaling pathway; microtubule depolymerization; mitotic cytokinesis; mitotic spindle organization and biogenesis; negative regulation of guanyl-nucleotide exchange factor activity; negative regulation of microtubule polymerization; negative regulation of Rho protein signal transduction; negative regulation of stress fiber formation; neuron projection development; positive regulation of cellular component movement; regulation of microtubule polymerization or depolymerization; response to virus; signal transduction