Heterogeneous Nuclear Ribonucleoprotein A1 (HNRPA1) Antibody – Rabbit Polyclonal

hnRNP A1: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication. Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with SEPT6. Interacts with HCV NS5B and with the 5'-UTR and 3'-UTR of HCV RNA. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear export; RNA splicing; RNA-binding; Spliceosome

Chromosomal Location of Human Ortholog: 15 F3|15 58.58 cM

Cellular Component: cytoplasm; intracellular ribonucleoprotein complex; nucleoplasm; nucleus; spliceosomal complex

Molecular Function: nucleic acid binding; RNA binding

Biological Process: alternative mRNA splicing, via spliceosome; mRNA processing; mRNA transport; RNA splicing; transport