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Interleukin-2 (IL2) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203089

IL-2, also known as T cell growth factor (TCGF), is an immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Interleukin-2 (IL2), Active Protein
Full Product Name
Interleukin-2 (C145S), 22-153 aa, Human, E Coli (Bioactivity Validated)
Product Gene Name
IL2 active protein
Product Synonym Names
IL-2; TCGF; Aldesleukin; T-cell growth factor; Interleukin-2; IL2; interleukin 2
Sequence
MPTSSSTKKT QLQLEHLLLD LQMILNGINN YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFSQSIIS TLT
Host
E Coli
Form/Format
Liquid in. Phosphate-Buffered Saline (pH 7.4)
Purity/Purification
> 95% by SDS-PAGE
Concentration
0.5 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 2-8°C for 1 week. Aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.
Molecular Weight
15.4kDa (133aa), confirmed by MALDI-TOF.
OMIM
X00695 Genomic DNA
3D Structure
ModBase 3D Structure for P60568
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Domain
22-153aa
Endotoxin Level
< 1 EU per 1og of protein (determined by LAL method)
Biological Activity
Measured in a cell proliferation assay using CTLL2 mouse cytotoxic T cells. The ED50 range ≥0.65ng/ml.
Tag
Non-Tagged
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for IL2 active protein

Hormones & Cytokines
Applications Tested/Suitable for IL2 active protein
SDS-PAGE, Bioactivity

SDS-Page of IL2 active protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain
IL2 Active Protein – Cat# MBS203089

Biological Activity of IL2 active protein

Human IL-2 (C145S) stimulates cell proliferation of the CTLL2 mouse cytotoxic T cells. The ED50 range ≥0.65 ng/ml
IL2 Active Protein, Biological Activity – Cat# MBS203089

Product References and Citations for IL2 active protein

Morgan DA., et al. (1976). Science, 193. 1007-8. ; Watson J., et al. (1980). Immunol Rev, 51. 257-78.; Taniguchi T., et al. (1983). Nature, 302. 305-10.;

Other Notes

Small volumes of IL2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL2 purchase

MBS203089 is an active protein targeting IL2. Also known as Interleukin-2 (C145S), 22-153 aa, Human, E Coli (Bioactivity Validated). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL2. It may not necessarily be applicable to this product.

NCBI GI #
28178861
NCBI GeneID
3558
NCBI Accession #
NP_000577.2
UniProt Primary Accession #
P60568
UniProt Secondary Accession #
P01585
UniProt Related Accession #
P60568
GenBank Nucleotide #
NM_000586.3
NCBI Official Full Name
interleukin-2
NCBI Official Synonym Full Names
interleukin 2
NCBI Official Symbol
IL2
NCBI Official Synonym Symbols
IL-2; TCGF; lymphokine
UniProt Protein Name
Interleukin-2
UniProt Synonym Protein Names
T-cell growth factor; TCGF; INN: Aldesleukin
Protein Family
Interleukin
UniProt Gene Name
IL2
UniProt Synonym Gene Names
IL-2; TCGF
NCBI Protein Information
interleukin-2

NCBI Summary for IL2

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
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UniProt Comments for IL2

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

Research Articles on IL2

1. Data reported that let-7i upregulates IL-2 expression by targeting the promoter TATA-box region, which functions as a positive regulator. In HIV-1 infection, the expression of let-7i in CD4(+) T cells is decreased by attenuating its promoter activity. The reduced let-7i miRNA expression led to a decline in IL-2 levels which contributes to CD4(+) T cells death.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL2 active protein

 Reference Product  PubMed Publications
 FOXP3 active protein  >135 publications with IL2 and FOXP3
 IL5 active protein  >117 publications with IL2 and IL5
 IFNG active protein  >107 publications with IL2 and IFNG
 IL2RA active protein  >69 publications with IL2 and IL2RA
 FOS active protein  >26 publications with IL2 and FOS
 IL2RG active protein  >17 publications with IL2 and IL2RG
 IL2RB active protein  >17 publications with IL2 and IL2RB
 CSF2 active protein  >16 publications with IL2 and CSF2
 STAT5A active protein  >11 publications with IL2 and STAT5A
 STAT5B active protein  >7 publications with IL2 and STAT5B

Pathways associated with IL2 active protein

 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Aryl Hydrocarbon Receptor Pathway antibodies  Aryl Hydrocarbon Receptor Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Calcium Signaling In The CD4+ TCR Pathway antibodies  Calcium Signaling In The CD4+ TCR Pathway Diagram

Diseases associated with IL2 active protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >432 publications with IL2 and Necrosis
 Inflammation Antibodies  >295 publications with IL2 and Inflammation
 Leukemia Antibodies  >261 publications with IL2 and Leukemia
 Melanoma Antibodies  >180 publications with IL2 and Melanoma
 Neoplasms, Experimental Antibodies  >164 publications with IL2 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >127 publications with IL2 and Kidney Diseases
 HIV Infections Antibodies  >95 publications with IL2 and HIV Infections
 Kidney Neoplasms Antibodies  >83 publications with IL2 and Kidney Neoplasms
 Lung Neoplasms Antibodies  >78 publications with IL2 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >59 publications with IL2 and Neoplasm Metastasis

Organs/Tissues associated with IL2 active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2591 publications with IL2 and Blood
 Uncharacterized Tissue Antibodies  >1 publications with IL2 and Uncharacterized Tissue
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