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CXCL10 Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9140258

Recombinant Human CXCL10 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Val22-Pro98) of human CXCL10 (Accession #P02778). More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CXCL10, Active Protein
Full Product Name
Recombinant Human CXCL10 Protein
Product Gene Name
CXCL10 active protein
Product Synonym Names
C-X-C Motif Chemokine 10; 10 kDa Interferon Gamma-Induced Protein; Gamma-IP10; IP-10; Small-Inducible Cytokine B10; CXCL10; INP10; SCYB10
Sequence
VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP
Host
E Coli
Form/Format
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH7.0.
Purity/Purification
>95% by SDS-PAGE.
Preparation and Storage
Store the lyophilized protein at -20 degree C to -80 degree C for long term.
After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.
OMIM
147310
3D Structure
ModBase 3D Structure for P02778
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Human
Endotoxin
< 1 EU/ug of the protein by LAL method.
Biological Activity
Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CXCR3. The ED50 for this effect is 0.03-0.18 ug/mL.
Reconstitution
Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.
Tag
No tag

Product Categories/Family for CXCL10 active protein

Cytokines & Cytokine Receptors
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of CXCL10 active protein

Recombinant Human CXCL10 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
Human CXCL10 Active Protein – Cat# MBS9140258

Other Notes

Small volumes of CXCL10 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCL10 purchase

MBS9140258 is an active protein targeting CXCL10. Also known as Recombinant Human CXCL10 Protein. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCL10. It may not necessarily be applicable to this product.

NCBI GI #
149999382
NCBI GeneID
3627
NCBI Accession #
NP_001556.2
UniProt Primary Accession #
P02778
UniProt Related Accession #
P02778
GenBank Nucleotide #
NP_001556.2
NCBI Official Full Name
C-X-C motif chemokine 10
NCBI Official Synonym Full Names
C-X-C motif chemokine ligand 10
NCBI Official Symbol
CXCL10
NCBI Official Synonym Symbols
C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10
UniProt Protein Name
C-X-C motif chemokine 10
UniProt Synonym Protein Names
10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Small-inducible cytokine B10
Protein Family
C-X-C motif chemokine
UniProt Gene Name
CXCL10
UniProt Synonym Gene Names
INP10; SCYB10; Gamma-IP10; IP-10
UniProt Entry Name
CXL10_HUMAN
NCBI Protein Information
C-X-C motif chemokine 10

NCBI Summary for CXCL10

This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]
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UniProt Comments for CXCL10

CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Chemokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region; external side of plasma membrane

Molecular Function: heparin binding; protein binding; CXCR3 chemokine receptor binding; chemokine activity; cAMP-dependent protein kinase regulator activity; receptor binding

Biological Process: muscle development; blood circulation; protein secretion; positive regulation of leukocyte chemotaxis; positive regulation of cAMP metabolic process; chemotaxis; signal transduction; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; cell surface receptor linked signal transduction; response to vitamin D; cell-cell signaling; positive regulation of cell proliferation; response to gamma radiation; positive regulation of transcription from RNA polymerase II promoter; immune response; positive regulation of release of sequestered calcium ion into cytosol; response to cold; inflammatory response; negative regulation of myoblast differentiation; regulation of protein kinase activity; defense response to virus
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Research Articles on CXCL10

1. high CXCL10 andSTAT1 expression may prompt highly suppressive func-tions, which was associated with decreased survival in mela-noma tumours.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CXCL10 active protein

 Reference Product  PubMed Publications
 CXCL9 active protein  >871 publications with CXCL10 and CXCL9
 CXCR3 active protein  >795 publications with CXCL10 and CXCR3
 CCL5 active protein  >614 publications with CXCL10 and CCL5
 CXCL11 active protein  >440 publications with CXCL10 and CXCL11
 CCR5 active protein  >167 publications with CXCL10 and CCR5
 CCL20 active protein  >103 publications with CXCL10 and CCL20
 CCL11 active protein  >97 publications with CXCL10 and CCL11
 CXCR2 active protein  >48 publications with CXCL10 and CXCR2
 CCR3 active protein  >47 publications with CXCL10 and CCR3
 CCR1 active protein  >46 publications with CXCL10 and CCR1

Pathways associated with CXCL10 active protein

 Products by Pathway  Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram

Diseases associated with CXCL10 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1078 publications with CXCL10 and Inflammation
 Necrosis Antibodies  >635 publications with CXCL10 and Necrosis
 Neoplasms Antibodies  >429 publications with CXCL10 and Neoplasms
 Lung Diseases Antibodies  >308 publications with CXCL10 and Lung Diseases
 Liver Diseases Antibodies  >203 publications with CXCL10 and Liver Diseases
 Cardiovascular Diseases Antibodies  >158 publications with CXCL10 and Cardiovascular Diseases
 Fibrosis Antibodies  >120 publications with CXCL10 and Fibrosis
 Neoplasms, Experimental Antibodies  >110 publications with CXCL10 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >80 publications with CXCL10 and Kidney Diseases
 Lung Injury Antibodies  >60 publications with CXCL10 and Lung Injury

Organs/Tissues associated with CXCL10 active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1900 publications with CXCL10 and Blood
 Lung Antibodies  >428 publications with CXCL10 and Lung
 Liver Antibodies  >249 publications with CXCL10 and Liver
 Kidney Antibodies  >168 publications with CXCL10 and Kidney
 Lymph Node Antibodies  >154 publications with CXCL10 and Lymph Node
 Muscle Antibodies  >113 publications with CXCL10 and Muscle
 Intestine Antibodies  >87 publications with CXCL10 and Intestine
 Nerve Antibodies  >57 publications with CXCL10 and Nerve
 Uterus Antibodies  >30 publications with CXCL10 and Uterus
 Placenta Antibodies  >24 publications with CXCL10 and Placenta
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