Interleukin-3 (IL3) Active Protein

Interleukin-3 (IL-3) stimulates the proliferation of hematopoietic pluripotent progenitor cells. It is secreted by activated T cells to support growth and differentiation of T cells from the bone marrow in an immune response. IL-3 exerts its biological activities through binding to specific cell surface receptors. IL-3 receptor is a complex consisting of alpha and beta subunits, which in turn induces activation of JAK2/ STAT5, induction of c-myc, and activation of the Ras pathway. Human IL3 is a protein of 15-17 kDa (133 amino acids). It is synthesized as a precursor containing a hydrophobic secretory signal sequence of 19 amino acids. IL3 contains two putative glycosylation sites at positions 15 and 70 and contains a single disulfide bond (Cys16/84). Recombinant human IL-3 was expressed in E Coli and purified by using conventional chromatography after refolding of the isolated inclusion bodies in a redox buffer.

Allan SM., et al. (2005), Nat. Rev. Immunol. 5:629.; Michaud DS., et al. (2006), Cancer Res. 66 (8):4525-30;

Small volumes of IL3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS203126 is an active protein targeting IL3. Also known as Interleukin-3, 20-152aa, Human, His tag, E Coli (Bioactivity Validated). Host: E Coli.