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AKR1B10 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203315

AKR1B10, also known as Aldo-keto reductase family 1, member B10, AKR1B10 is a monomeric protein that efficiently catalyzes the reduction of aromatic and aliphatic aldehydes and ketones. AKR1B10 is ubiquitously expressed in many human tissues but is highly… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
AKR1B10, Active Protein
Full Product Name
AKR1B10, 1-316aa, Human, E Coli (Bioactivity Validated)
Product Gene Name
Product Synonym Names
Aldo-keto reductase family 1 member B10; AKR1B11; AKR1B12; ALDRLn; ARL-1; ARL1; HIS; HIS; Aldo-keto reductase family 1; member B10; AKR1B10; Aldo-keto reductase family 1; member B10 Aldose reductase like; Aldose reductase related protein; ARL 1; hARP; SI reductase; Small intestine reductase.
Sequence
MATFVELSTK AKMPIVGLGT WKSPLGKVKE AVKVAIDAGY RHIDCAYVYQ NEHEVGEAIQ EKIQEKAVKR EDLFIVSKLW PTFFERPLVR KAFEKTLKDL KLSYLDVYLI HWPQGFKSGD DLFPKDDKGN AIGGKATFLD AWEAMEELVD EGLVKALGVS NFSHFQIEKL LNKPGLKYKP VTNQVECHPY LTQEKLIQYC HSKGITVTAY SPLGSPDRPW AKPEDPSLLE DPKIKEIAAK HKKTAAQVLI RFHIQRNVIV IPKSVTPARI VENIQVFDFK LSDEEMATIL SFNRNWRACN VLQSSHLEDY PFDAEY
Host
E Coli
Form/Format
Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol.
Purity/Purification
> 95% by SDS-PAGE
Concentration
1 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Aliquot and store at -20°C to -80°C. Avoid repeated freeze and thawing cycles.
Molecular Weight
36 kDa (316aa), confirmed by MALDI-TOF.
OMIM
U37100 mRNA
3D Structure
ModBase 3D Structure for O60218
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Tag
Non-Tagged
Endotoxin Level
< 1 EU per 1ug of protein (determined by LAL method)
Biological Activity
Specific activity is > 1,500pmol/min/ug, and was obtained by measuring the decrease of NADP in absorbance at 340nm resulting from NADPH at pH 7.0 at 37C.

Product Categories/Family for AKR1B10 active protein

Applications Tested/Suitable for AKR1B10 active protein
SDS-PAGE, Enzyme Activity

SDS-Page of AKR1B10 active protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain
AKR1B10 Active Protein – Cat# MBS203315

Product References and Citations for AKR1B10 active protein

Yabe D., et al. (1997) J Biol Chem. 272 (29):18232-9.; Vorum H., et al. (1998) Biochim Biophys Acta. 1386 (1):121-31.;

Other Notes

Small volumes of AKR1B10 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AKR1B10 purchase

MBS203315 is an active protein targeting AKR1B10. Also known as AKR1B10, 1-316aa, Human, E Coli (Bioactivity Validated). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for AKR1B10. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
aldo-keto reductase family 1 member B10
NCBI Official Synonym Full Names
aldo-keto reductase family 1 member B10
NCBI Official Symbol
AKR1B10
NCBI Official Synonym Symbols
HIS; HSI; ARL1; ARL-1; ALDRLn; AKR1B11; AKR1B12
UniProt Protein Name
Aldo-keto reductase family 1 member B10
UniProt Synonym Protein Names
ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase
UniProt Gene Name
AKR1B10
UniProt Synonym Gene Names
AKR1B11; ARP; hARP; SI reductase
NCBI Protein Information
aldo-keto reductase family 1 member B10

NCBI Summary for AKR1B10

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]
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UniProt Comments for AKR1B10

Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with AKR1B10 active protein

 Reference Product  PubMed Publications
 ALDH1B1 active protein  >1 publications with AKR1B10 and ALDH1B1
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