ALDH3A1 Active Protein

Name: ALDH3A1 Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203521
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203521

ALDH3A1, also known as Aldehyde dehydrogenase 3 family memberA1, is involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein forms a… More details

$245 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ALDH3A1, Active Protein

Full Product Name

ALDH3A1, 1-453aa, Human, His tag, E Coli (Bioactivity Validated)

Product Gene Name

ALDH3A1 active protein

Product Synonym Names

Aldehyde dehydrogenase 3 family memberA1; ALDHIII; ALDH3; Aldehyde dehydrogenase 3 family; memberA1 AHD 4.AHD C; AHD4; AHDC; ALDH III; Aldehyde dehydrogenase 3; Aldehyde dehydrogenase 3 family member A1; Aldehyde dehydrogenase 3A1; Aldehyde dehydrogenase class 3; Aldehyde dehydrogenase dimeric NADP preferring; Aldehyde dehydrogenase family 3 member A1; Aldehyde dehydrogenase family 3 subfamily A1; Aldehyde dehydrogenase isozyme 3; Aldehyde dehydrogenase type III; ALDH 3; ALDH 3A1; ALDH3 A1; ALDH3A 1; MGC10406; Stomach aldehyde dehydrogenase; Tumor associated aldehyde dehydrogenase tumor ALDH.

Sequence

MGSSHHHHHH SSGLVPRGSH MSKISEAVKR ARAAFSSGRT RPLQFRIQQL EALQRLIQEQ EQELVGALAA DLHKNEWNAY YEEVVYVLEE IEYMIQKLPE WAADEPVEKT PQTQQDELYI HSEPLGVVLV IGTWNYPFNL TIQPMVGAIA AGNAVVLKPS ELSENMASLL ATIIPQYLDK DLYPVINGGV PETTELLKER FDHILYTGST GVGKIIMTAA AKHLTPVTLE LGGKSPCYVD KNCDLDVACR RIAWGKFMNS GQTCVAPDYI LCDPSIQNQI VEKLKKSLKE FYGEDAKKSR DYGRIISARH FQRVMGLIEG QKVAYGGTGD AATRYIAPTI LTDVDPQSPV MQEEIFGPVL PIVCVRSLEE AIQFINQREK PLALYMFSSN DKVIKKMIAE TSSGGVAAND VIVHITLHSL PFGGVGNSGM GSYHGKKSFE TFSHRRSCLV RPLMNDEGLK VRYPPSPAKM TQH

Host

E Coli

Form/Format

Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol 0.1M NaCl

Purity/Purification

> 95% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

52.5 kDa (473aa)

OMIM

M74542 mRNA

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Antigen Species

Human

Tag Information

His-tag

Biological Activity

Specific activity is > 5,000 pmol/min/ug. It was obtained by measuring the increase of NADPH in absorbance at 340nm resurting from the reduction of NADP at pH9.0 at 37C.

Product Categories/Family for ALDH3A1 active protein

Redox Proteins

Applications Tested/Suitable for ALDH3A1 active protein

SDS-PAGE

Product References and Citations for ALDH3A1 active protein

Estey T., et al. (2007) Exp Eye Res. 84 (1):3-12; Bogucka M, et al. (2009) Acta Pol Pharm. 66 (5):477-82.;

Other Notes

Small volumes of ALDH3A1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALDH3A1 purchase

MBS203521 is an active protein targeting ALDH3A1. Also known as ALDH3A1, 1-453aa, Human, His tag, E Coli (Bioactivity Validated). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for ALDH3A1. It may not necessarily be applicable to this product.

NCBI GI #

13325114

NCBI GeneID

218

NCBI Accession #

AAH04370

UniProt Secondary Accession #

Q9BT37; A8K828

UniProt Related Accession #

P30838

NCBI Official Full Name

Aldehyde dehydrogenase 3 family, memberA1

NCBI Official Synonym Full Names

aldehyde dehydrogenase 3 family member A1

NCBI Official Symbol

ALDH3A1

NCBI Official Synonym Symbols

ALDH3; ALDHIII

UniProt Protein Name

Aldehyde dehydrogenase, dimeric NADP-preferring

UniProt Synonym Protein Names

ALDHIII; Aldehyde dehydrogenase 3; Aldehyde dehydrogenase family 3 member A1

Protein Family

Aldehyde dehydrogenase

UniProt Gene Name

ALDH3A1

UniProt Synonym Gene Names

ALDH3

NCBI Protein Information

aldehyde dehydrogenase, dimeric NADP-preferring

NCBI Summary for ALDH3A1

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]

UniProt Comments for ALDH3A1

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (). May play a role in preventing corneal damage caused by ultraviolet light ().

Research Articles on ALDH3A1

1. ALDH3A1 appears to play an essential role in protecting cellular proteins against aggregation under stress conditions

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ALDH3A1 active protein

Reference Product	PubMed Publications
ADH1B active protein	>5 publications with ALDH3A1 and ADH1B
ADH4 active protein	>3 publications with ALDH3A1 and ADH4
ADH7 active protein	>3 publications with ALDH3A1 and ADH7
ADH5 active protein	>1 publications with ALDH3A1 and ADH5

Pathways associated with ALDH3A1 active protein

Products by Pathway	Pathway Diagram
2'-deoxy-alpha-D-ribose 1-phosphate Degradation Pathway antibodies	2'-deoxy-alpha-D-ribose 1-phosphate Degradation Pathway Diagram
Aryl Hydrocarbon Receptor Pathway antibodies	Aryl Hydrocarbon Receptor Pathway Diagram
Biological Oxidations Pathway antibodies	Biological Oxidations Pathway Diagram
Chemical Carcinogenesis Pathway antibodies	Chemical Carcinogenesis Pathway Diagram
Chemical Carcinogenesis Pathway antibodies	Chemical Carcinogenesis Pathway Diagram
Drug Metabolism - Cytochrome P450 Pathway antibodies	Drug Metabolism - Cytochrome P450 Pathway Diagram
Drug Metabolism - Cytochrome P450 Pathway antibodies	Drug Metabolism - Cytochrome P450 Pathway Diagram
Glycolysis / Gluconeogenesis Pathway antibodies	Glycolysis / Gluconeogenesis Pathway Diagram
Glycolysis / Gluconeogenesis Pathway antibodies	Glycolysis / Gluconeogenesis Pathway Diagram
Histidine Metabolism Pathway antibodies	Histidine Metabolism Pathway Diagram

Diseases associated with ALDH3A1 active protein

Disease Name	Pubmed Publications
Carcinoma Antibodies	>28 publications with ALDH3A1 and Carcinoma
Lung Diseases Antibodies	>21 publications with ALDH3A1 and Lung Diseases
Lung Neoplasms Antibodies	>21 publications with ALDH3A1 and Lung Neoplasms
Breast Neoplasms Antibodies	>13 publications with ALDH3A1 and Breast Neoplasms
Liver Neoplasms Antibodies	>11 publications with ALDH3A1 and Liver Neoplasms
Neoplasms, Experimental Antibodies	>11 publications with ALDH3A1 and Neoplasms, Experimental
Liver Diseases Antibodies	>9 publications with ALDH3A1 and Liver Diseases
Disease Models, Animal Antibodies	>6 publications with ALDH3A1 and Disease Models, Animal
Nervous System Diseases Antibodies	>6 publications with ALDH3A1 and Nervous System Diseases
Carcinoma, Hepatocellular Antibodies	>6 publications with ALDH3A1 and Carcinoma, Hepatocellular

Organs/Tissues associated with ALDH3A1 active protein

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>49 publications with ALDH3A1 and Eye
Lung Antibodies	>28 publications with ALDH3A1 and Lung
Liver Antibodies	>20 publications with ALDH3A1 and Liver
Stomach Antibodies	>10 publications with ALDH3A1 and Stomach
Mouth Antibodies	>8 publications with ALDH3A1 and Mouth
Intestine Antibodies	>5 publications with ALDH3A1 and Intestine
Skin Antibodies	>4 publications with ALDH3A1 and Skin
Brain Antibodies	>3 publications with ALDH3A1 and Brain
Prostate Antibodies	>2 publications with ALDH3A1 and Prostate
Testis Antibodies	>1 publications with ALDH3A1 and Testis