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AKR1C1 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203641

AKR1C1 is member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The… More details

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Product Overview

Online Datasheet in PDF
Product Name
AKR1C1, Active Protein
Full Product Name
AKR1C1, 1-323aa, Human, His tag, E Coli (Bioactivity Validated)
Product Gene Name
AKR1C1 active protein
Product Synonym Names
Aldo-keto reductase family 1 member C1; 20-alpha-HSD; DD1/DD2; HBAB; DDH; DDH1; Aldo-keto reductase family 1; member C1 20 alpha (3 alpha) hydroxysteroid dehydrogenase; 20 alpha hydroxysteroid dehydrogenase; 2ALPHAHSD; AK1C1; MBAB; Aldo keto reductase family 1 member C1; C9; Chlordecone reductase homolog; Chlordecone reductase homolog HAKRC; DD1; Dihydrodiol dehydrogenase 1; Dihydrodiol dehydrogenase 1/2; H37; HAKRC; Hepatic dihydrodiol dehydrogenase; High affinity hepatic bile acid-binding protein; Trans-1,2 dihydrobenzene 1,2 diol dehydrogenase; Type II 3 alpha hydroxysteroid dehydrogenase
Sequence
MGSSHHHHHH SSGLVPRGSH MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEATKL AIEAGFRHID SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCNSH RPELVRPALE RSLKNLQLDY VDLYLIHFPV SVKPGEEVIP KDENGKILFD TVDLCATWEA VEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNQR KLLDFCKSKD IVLVAYSALG SHREEPWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTS EEMKAIDGLN RNVRYLTLDI FAGPPNYPFS DEY
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 1mM DTT, 20% glycerol
Purity/Purification
> 90% by SDS-PAGE
Concentration
0.5 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
38.9 kDa (343aa), confirmed by MALDI-TOF.
OMIM
M86609 mRNA
3D Structure
ModBase 3D Structure for Q04828
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Antigen Species
Human
Tag Information
His-tag
Biological Activity
Specific activity is > 500 pmol/min/ug, and is defined as the amount of enzyme that catalyze the oxidation of 1.0 pmole 1-Acenaphthenol in the presence of NADP per minute at pH 8.8 at 25C.

Product Categories/Family for AKR1C1 active protein

Redox Proteins
Applications Tested/Suitable for AKR1C1 active protein
SDS-PAGE

SDS-Page of AKR1C1 active protein

AKR1C1 Active Protein – Cat# MBS203641

Product References and Citations for AKR1C1 active protein

Zhang Y., et al. (2000) J. Mol. Endocrinol. 25:221-228; Zhang Y., et al. (2009) Mol Cell Endicrinol. 298 (1-2):76-83;

Other Notes

Small volumes of AKR1C1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AKR1C1 purchase

MBS203641 is an active protein targeting AKR1C1. Also known as AKR1C1, 1-323aa, Human, His tag, E Coli (Bioactivity Validated). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for AKR1C1. It may not necessarily be applicable to this product.

NCBI GI #
5453543
NCBI GeneID
1645
NCBI Accession #
NP_001344
UniProt Primary Accession #
Q04828
UniProt Secondary Accession #
P52896; Q5SR15; Q7M4N2; Q9UCX2
UniProt Related Accession #
Q04828
GenBank Nucleotide #
NM_001353.5
NCBI Official Full Name
aldo-keto reductase family 1 member C1
NCBI Official Synonym Full Names
aldo-keto reductase family 1 member C1
NCBI Official Symbol
AKR1C1
NCBI Official Synonym Symbols
C9; DD1; DDH; DDH1; H-37; HBAB; MBAB; HAKRC; DD1/DD2; 2-ALPHA-HSD; 20-ALPHA-HSD
UniProt Protein Name
Aldo-keto reductase family 1 member C1
UniProt Synonym Protein Names
20-alpha-hydroxysteroid dehydrogenase (EC:1.1.1.149
Protein Family
Aldo-keto reductase family
UniProt Gene Name
AKR1C1
UniProt Synonym Gene Names
DDH; DDH1; 20-alpha-HSD; DD1/DD2; HBAB
NCBI Protein Information
aldo-keto reductase family 1 member C1

NCBI Summary for AKR1C1

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]
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UniProt Comments for AKR1C1

Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.
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Research Articles on AKR1C1

1. Data show that increased levels of AKR1C1/C2 enhanced the sensitivity of esophageal squamous cell carcinoma (ESCC) cells to ethyl-3,4-dihydroxybenzoate (EDHB).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with AKR1C1 active protein

 Reference Product  PubMed Publications
 AKR1C3 active protein  >105 publications with AKR1C1 and AKR1C3
 SRD5A1 active protein  >14 publications with AKR1C1 and SRD5A1
 CYP1A1 active protein  >11 publications with AKR1C1 and CYP1A1
 AKR1D1 active protein  >7 publications with AKR1C1 and AKR1D1
 UGT2B15 active protein  >4 publications with AKR1C1 and UGT2B15
 HSD3B2 active protein  >3 publications with AKR1C1 and HSD3B2
 HSD3B1 active protein  >3 publications with AKR1C1 and HSD3B1
 CYP17A1 active protein  >2 publications with AKR1C1 and CYP17A1
 UGT2B17 active protein  >2 publications with AKR1C1 and UGT2B17

Pathways associated with AKR1C1 active protein

 Products by Pathway  Pathway Diagram
 Benzo(a)pyrene Metabolism Pathway antibodies  Benzo(a)pyrene Metabolism Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Fat-soluble Vitamins Pathway antibodies  Metabolism Of Fat-soluble Vitamins Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Metapathway Biotransformation antibodies  Metapathway Biotransformation Diagram
 Retinoid Metabolism And Transport Pathway antibodies  Retinoid Metabolism And Transport Pathway Diagram

Diseases associated with AKR1C1 active protein

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >21 publications with AKR1C1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >14 publications with AKR1C1 and Adenocarcinoma
 Lung Neoplasms Antibodies  >14 publications with AKR1C1 and Lung Neoplasms
 Endometriosis Antibodies  >12 publications with AKR1C1 and Endometriosis
 Liver Neoplasms Antibodies  >7 publications with AKR1C1 and Liver Neoplasms
 Liver Diseases Antibodies  >6 publications with AKR1C1 and Liver Diseases
 Inflammation Antibodies  >5 publications with AKR1C1 and Inflammation
 Neoplasms, Hormone-Dependent Antibodies  >5 publications with AKR1C1 and Neoplasms, Hormone-Dependent
 Endometrial Neoplasms Antibodies  >5 publications with AKR1C1 and Endometrial Neoplasms
 Immune System Diseases Antibodies  >5 publications with AKR1C1 and Immune System Diseases

Organs/Tissues associated with AKR1C1 active protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >37 publications with AKR1C1 and Liver
 Lung Antibodies  >33 publications with AKR1C1 and Lung
 Ovary Antibodies  >13 publications with AKR1C1 and Ovary
 Uterus Antibodies  >12 publications with AKR1C1 and Uterus
 Blood Antibodies  >11 publications with AKR1C1 and Blood
 Adipose Tissue Antibodies  >10 publications with AKR1C1 and Adipose Tissue
 Connective Tissue Antibodies  >9 publications with AKR1C1 and Connective Tissue
 Skin Antibodies  >8 publications with AKR1C1 and Skin
 Brain Antibodies  >7 publications with AKR1C1 and Brain
 Kidney Antibodies  >7 publications with AKR1C1 and Kidney
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