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PHLDA2 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203744

PHLDA2, also known as Pleckstrin homology-like domain family A member 2, is a cytoplasmic protein that is involved in fetal and placental growth. It is an apoptosis-related protein that acts as a negative growth regulator and is expressed during normal human… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PHLDA2, Recombinant Protein
Full Product Name
PHLDA2, 1-152aa, Human, His tag, E Coli
Product Synonym Names
Pleckstrin homology-like domain family A member 2; BRW1C; BWR1C; HLDA2; IPL; TSSC3; Pleckstrin homology-like domain family A member 2 Beckwith Wiedemann syndrome chromosome region 1 candidate protein C; BRW 1C; BWR 1C; HLDA 2; HLDA2; Imprinted in placenta and liver; Imprinted in placenta and liver protein; p17 Beckwith Wiedemann region 1C; p17 BWR1C; PHLDA 2; Pleckstrin homology like domain family A member 2; TSSC 3; Tumor supressing STF cDNA 3; Tumor suppressing STF cDNA 3 protein; Tumor suppressing subchromosomal transferable; fragment candidate gene 3 protein; Tumor suppressing subchromosomal transferable fragment cDNA 3; Tumor suppressing subtransferable candidate 3
Sequence
MGSSHHHHHH SSGLVPRGSH MKSPDEVLRE GELEKRSDSL FQLWKKKRGV LTSDRLSLFP ASPRARPKEL RFHSILKVDC VERTGKYVYF TIVTTDHKEI DFRCAGESCW NAAIALALID FQNRRALQDF RSRQERTAPA APAEDAVAAA AAAPSEPSEP SRPSPQPKPR TP
Host
E Coli
Form/Format
Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT
Purity/Purification
> 80% by SDS-PAGE
Concentration
0.5 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
19.2 kDa (172aa), confirmed by MALDI-TOF
OMIM
AF019953 mRNA
3D Structure
ModBase 3D Structure for Q53GA4
Antigen Species
Human
Tag Information
His-tag

Product Categories/Family for PHLDA2 recombinant protein

Applications Tested/Suitable for PHLDA2 recombinant protein
SDS-PAGE

Product References and Citations for PHLDA2 recombinant protein

Lee MP, et al. (1998) Cancer Res.. 58 (5):1052-6.; Frank D. et al. (2000) Mamm Genome. 10 (12):1150-9..;

Other Notes

Small volumes of PHLDA2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PHLDA2 purchase

MBS203744 is a recombinant protein targeting PHLDA2. Also known as PHLDA2, 1-152aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PHLDA2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
pleckstrin homology-like domain family A member 2
NCBI Official Synonym Full Names
pleckstrin homology like domain family A member 2
NCBI Official Symbol
PHLDA2
NCBI Official Synonym Symbols
IPL; BRW1C; BWR1C; HLDA2; TSSC3
UniProt Protein Name
Pleckstrin homology-like domain family A member 2
UniProt Synonym Protein Names
Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein; Imprinted in placenta and liver protein; Tumor-suppressing STF cDNA 3 protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein; p17-Beckwith-Wiedemann region 1 C; p17-BWR1C
UniProt Gene Name
PHLDA2
UniProt Synonym Gene Names
BWR1C; HLDA2; IPL; TSSC3; p17-BWR1C
NCBI Protein Information
pleckstrin homology-like domain family A member 2

NCBI Summary for PHLDA2

This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. [provided by RefSeq, Oct 2010]
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UniProt Comments for PHLDA2

Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids ().

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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