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ARF4 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203759

ARF4 is a member of the ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The ARF… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ARF4, Recombinant Protein
Full Product Name
ARF4, 1-180aa, Human, His tag, E Coli
Product Gene Name
ARF4 recombinant protein
Product Synonym Names
ADP-ribosylation factor 4; ARF2
Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMGLTIS SLFSRLFGKK QMRILMVGLD AAGKTTILYK LKLGEIVTTI PTIGFNVETV EYKNICFTVW DVGGQDRIRP LWKHYFQNTQ GLIFVVDSND RERIQEVADE LQKMLLVDEL RDAVLLLFAN KQDLPNAMAI SEMTDKLGLQ SLRNRTWYVQ ATCATQGTGL YEGLDWLSNE LSKR
Host
E Coli
Form/Format
Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 0.2M NaCl, 5mM DTT, 20% glycerol
Purity/Purification
> 95% by SDS-PAGE
Concentration
0.5 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
23.0 kDa (204aa), confirmed by MALDI-TOF
OMIM
M36341 mRNA
3D Structure
ModBase 3D Structure for P18085
Antigen Species
Human
Tag Information
His-tag

Product Categories/Family for ARF4 recombinant protein

Signal Transduction
Applications Tested/Suitable for ARF4 recombinant protein
SDS-PAGE

SDS-Page of ARF4 recombinant protein

ARF4 Recombinant Protein – Cat# MBS203759

Product References and Citations for ARF4 recombinant protein

Mazelova J., et al. (2009) EMBO J. 28 (3):183-92.; Woo IS., et al. (2009) Cancer Lett. 276 (1):53-60.;

Other Notes

Small volumes of ARF4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARF4 purchase

MBS203759 is a recombinant protein targeting ARF4. Also known as ARF4, 1-180aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for ARF4. It may not necessarily be applicable to this product.

NCBI GI #
4502205
NCBI GeneID
378
NCBI Accession #
NP_001651
UniProt Primary Accession #
P18085
UniProt Secondary Accession #
P21371; B2R7J7
UniProt Related Accession #
P18085
GenBank Nucleotide #
NM_001660.3
NCBI Official Full Name
ADP-ribosylation factor 4
NCBI Official Synonym Full Names
ADP ribosylation factor 4
NCBI Official Symbol
ARF4
NCBI Official Synonym Symbols
ARF2
UniProt Protein Name
ADP-ribosylation factor 4
Protein Family
ADP-ribosylation factor
UniProt Gene Name
ARF4
UniProt Synonym Gene Names
ARF2
NCBI Protein Information
ADP-ribosylation factor 4

NCBI Summary for ARF4

This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for ARF4

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Research Articles on ARF4

1. Data suggest that, when compared to intestinal epithelial cells (IECs) from germ-free mice, IECs from mice with commensal bacteria exhibit increased expression of microRNA-21-5p; up-regulation of expression of microRNA-21-5p appears to increase IEC permeability and up-regulates ADP ribosylation factor 4 (Arf4/ARF4) in mouse and human cells.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ARF4 recombinant protein

 Reference Product  PubMed Publications
 ARF1 recombinant protein  >29 publications with ARF4 and ARF1
 GBF1 recombinant protein  >9 publications with ARF4 and GBF1
 ASAP1 recombinant protein  >9 publications with ARF4 and ASAP1
 PLD2 recombinant protein  >1 publications with ARF4 and PLD2
 ARFGAP1 recombinant protein  >1 publications with ARF4 and ARFGAP1
 COPG2 recombinant protein  >1 publications with ARF4 and COPG2
 ARFGAP3 recombinant protein  >1 publications with ARF4 and ARFGAP3

Pathways associated with ARF4 recombinant protein

 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 COPI-dependent Golgi-to-ER Retrograde Traffic Pathway antibodies  COPI-dependent Golgi-to-ER Retrograde Traffic Pathway Diagram
 COPI-mediated Anterograde Transport Pathway antibodies  COPI-mediated Anterograde Transport Pathway Diagram
 Cargo Trafficking To The Periciliary Membrane Pathway antibodies  Cargo Trafficking To The Periciliary Membrane Pathway Diagram
 Cilium Assembly Pathway antibodies  Cilium Assembly Pathway Diagram
 ER To Golgi Anterograde Transport Pathway antibodies  ER To Golgi Anterograde Transport Pathway Diagram
 ErbB1 Downstream Signaling Pathway antibodies  ErbB1 Downstream Signaling Pathway Diagram
 Golgi-to-ER Retrograde Transport Pathway antibodies  Golgi-to-ER Retrograde Transport Pathway Diagram
 Intra-Golgi And Retrograde Golgi-to-ER Traffic Pathway antibodies  Intra-Golgi And Retrograde Golgi-to-ER Traffic Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram

Diseases associated with ARF4 recombinant protein

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >4 publications with ARF4 and Kidney Diseases
 Inflammation Antibodies  >2 publications with ARF4 and Inflammation
 Immune System Diseases Antibodies  >1 publications with ARF4 and Immune System Diseases
 Lung Diseases Antibodies  >1 publications with ARF4 and Lung Diseases
 Disease Models, Animal Antibodies  >1 publications with ARF4 and Disease Models, Animal
 Liver Diseases Antibodies  >1 publications with ARF4 and Liver Diseases
 Hypertrophy Antibodies  >1 publications with ARF4 and Hypertrophy
 Poisoning Antibodies  >1 publications with ARF4 and Poisoning
 Abnormalities, Multiple Antibodies  >1 publications with ARF4 and Abnormalities, Multiple
 Weight Loss Antibodies  >1 publications with ARF4 and Weight Loss

Organs/Tissues associated with ARF4 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >9 publications with ARF4 and Kidney
 Brain Antibodies  >9 publications with ARF4 and Brain
 Eye Antibodies  >6 publications with ARF4 and Eye
 Heart Antibodies  >6 publications with ARF4 and Heart
 Lung Antibodies  >5 publications with ARF4 and Lung
 Blood Antibodies  >4 publications with ARF4 and Blood
 Muscle Antibodies  >4 publications with ARF4 and Muscle
 Pancreas Antibodies  >2 publications with ARF4 and Pancreas
 Intestine Antibodies  >2 publications with ARF4 and Intestine
 Embryonic Tissue Antibodies  >2 publications with ARF4 and Embryonic Tissue
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