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TPM2 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203862

Tropomyosin beta chain isoform 2, also known as TPM2, is a member of the actin filament binding protein family which mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TPM2, Recombinant Protein
Full Product Name
TPM2, 1-284aa, Human, His tag, E Coli
Product Gene Name
Product Synonym Names
Tropomyosin beta chain isoform 2; AMCD1; DA1; DA2B; NEM4; TMSB
Sequence
MGSSHHHHHH SSGLVPRGSH MDAIKKKMQM LKLDKENAID RAEQAEADKK QAEDRCKQLE EEQQALQKKL KGTEDEVEKY SESVKEAQEK LEQAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA DESERGMKVI ENRAMKDEEK MELQEMQLKE AKHIAEDSDR KYEEVARKLV ILEGELERSE ERAEVAESRA RQLEEELRTM DQALKSLMAS EEEYSTKEDK YEEEIKLLEE KLKEAETRAE FAERSVAKLE KTIDDLEETL ASAKEENVEI HQTLDQTLLE LNNL
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 1mM DTT, 30% glycerol, 100mM NaCl
Purity/Purification
> 90% by SDS-PAGE
Concentration
0.5 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
35.1 kDa (304aa) confirmed by MALDI-TOF (molecular weight on SDS-PAGE will appear higher)
OMIM
M12126 mRNA
3D Structure
ModBase 3D Structure for P07951
Antigen Species
Human
Tag Information
His-tag

Product Categories/Family for TPM2 recombinant protein

Applications Tested/Suitable for TPM2 recombinant protein
SDS-PAGE

Product References and Citations for TPM2 recombinant protein

Hunt CC., et al. (1995) Cytogenet Cell Genet. 71 (1):94-5.; Tiso N., et al. (1997) Biochem Biophys Res Commun. 13 (2):347-50.;

Other Notes

Small volumes of TPM2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TPM2 purchase

MBS203862 is a recombinant protein targeting TPM2. Also known as TPM2, 1-284aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TPM2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
tropomyosin beta chain isoform Tpm2.1sm/cy
NCBI Official Synonym Full Names
tropomyosin 2
NCBI Official Symbol
TPM2
NCBI Official Synonym Symbols
DA1; DA2B; NEM4; TMSB; AMCD1; HEL-S-273
UniProt Protein Name
Tropomyosin beta chain
UniProt Synonym Protein Names
Beta-tropomyosin; Tropomyosin-2
Protein Family
UniProt Gene Name
TPM2
UniProt Synonym Gene Names
TMSB
NCBI Protein Information
tropomyosin beta chain

NCBI Summary for TPM2

This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
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UniProt Comments for TPM2

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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