GATA Binding Protein 2 (GATA2) Antibody – Rabbit Polyclonal

This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

GATA2: Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. Endothelial cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: nucleoplasm; nucleus; transcription factor complex

Molecular Function: chromatin binding; protein binding; transcription factor activity; transcription factor binding

Biological Process: blood coagulation; gut development; heart development; negative regulation of fat cell differentiation; negative regulation of Notch signaling pathway; organ morphogenesis; positive regulation of angiogenesis; positive regulation of phagocytosis; positive regulation of transcription from RNA polymerase II promoter; tissue development; transcription, DNA-dependent

Disease: Immunodeficiency 21; Lymphedema, Primary, With Myelodysplasia; Myelodysplastic Syndrome