BAD01488.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,810 Da
NCBI Official Full Name
Lymphotoxin beta receptor, partial
NCBI Official Synonym Full Names
lymphotoxin beta receptor
NCBI Official Synonym Symbols
CD18; TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III [Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 3
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 3
UniProt Synonym Protein Names
Lymphotoxin-beta receptor; Tumor necrosis factor C receptor; Tumor necrosis factor receptor 2-related protein; Tumor necrosis factor receptor type III; TNF-RIII; TNFR-III
UniProt Synonym Gene Names
NCBI Summary for LTbR
This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]
UniProt Comments for LTbR
LTBR: Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: identical protein binding; protein binding; tumor necrosis factor receptor activity; ubiquitin protein ligase binding
Biological Process: immune response; inflammatory response; multicellular organismal development; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; regulation of cell proliferation; response to lipopolysaccharide; signal transduction; tumor necrosis factor-mediated signaling pathway
Research Articles on LTbR
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Products associated with anti-LTbR antibody
Pathways associated with anti-LTbR antibody
Diseases associated with anti-LTbR antibody
Organs/Tissues associated with anti-LTbR antibody
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