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Haa,o (HAAO) Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204540

HAAO is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. This protein catalyzes the synthesis of quinolinic acid (QuIN) from 3-hydroxyanthranilic acid. QuIN is an excitotoxin whose toxicity… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
HAA,O (HAAO), Recombinant Protein
Full Product Name
HAA,O, 1-286aa, Human, His tag, E Coli
Product Gene Name
HAAO recombinant protein
Product Synonym Names
3-hydroxyanthranilate 34-dioxygenase; 3-hydroxyanthranilate 3,4-dioxygenase; 3-HAO; HAO
Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMERRLG VRAWVKENRG SFQPPVCNKL MHQEQLKVMF IGGPNTRKDY HIEEGEEVFY QLEGDMVLRV LEQGKHRDVV IRQGEIFLLP ARVPHSPQRF ANTVGLVVER RRLETELDGL RYYVGDTMDV LFEKWFYCKD LGTQLAPIIQ EFFSSEQYRT GKPIPDQLLK EPPFPLSTRS IMEPMSLDAW LDSHHRELQA GTPLSLFGDT YETQVIAYGQ GSSEGLRQNV DVWLWQLEGS SVVTMGGRRL SLAPDDSLLV LAGTSYAWER TQGSVALSVT QDPACKKPLG
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Purity/Purification
> 90% by SDS-PAGE
Concentration
0.5 mg/ml (determined by BCA assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
35kDa (310aa), confirmed by MALDI-TOF
OMIM
Z29481 mRNA
3D Structure
ModBase 3D Structure for P46952
Antigen Species
Human
Tag Information
His-tag

Product Categories/Family for HAAO recombinant protein

Metabolism
Applications Tested/Suitable for HAAO recombinant protein
SDS-PAGE

SDS-Page of HAAO recombinant protein

HAAO Recombinant Protein – Cat# MBS204540

Product References and Citations for HAAO recombinant protein

Malherbe P., et al. (1994) J Biol Chem. 13;269 (19):13792-7.

Other Notes

Small volumes of HAAO recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HAAO purchase

MBS204540 is a recombinant protein targeting HAAO. Also known as HAA,O, 1-286aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for HAAO. It may not necessarily be applicable to this product.

NCBI GI #
188497625
NCBI GeneID
23498
NCBI Accession #
NP_036337
UniProt Primary Accession #
P46952
UniProt Secondary Accession #
Q53QZ7; Q8N6N9; A6NE56; B4DIN2
UniProt Related Accession #
P46952
GenBank Nucleotide #
NM_012205.2
NCBI Official Full Name
3-hydroxyanthranilate 3,4-dioxygenase
NCBI Official Synonym Full Names
3-hydroxyanthranilate 3,4-dioxygenase
NCBI Official Symbol
HAAO
NCBI Official Synonym Symbols
HAO; 3-HAO; VCRL1
UniProt Protein Name
3-hydroxyanthranilate 3,4-dioxygenase
UniProt Synonym Protein Names
3-hydroxyanthranilate oxygenase
UniProt Gene Name
HAAO
UniProt Synonym Gene Names
3-HAO; HAD
NCBI Protein Information
3-hydroxyanthranilate 3,4-dioxygenase

NCBI Summary for HAAO

3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]
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UniProt Comments for HAAO

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

Research Articles on HAAO

1. Here, the first crystal structure of human 3-HAO with the native iron bound in its active site is presented, together with an additional structure with zinc (a known inhibitor of human 3-HAO) bound in the active site.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with HAAO recombinant protein

 Reference Product  PubMed Publications
 KMO recombinant protein  >3 publications with HAAO and KMO
 KYNU recombinant protein  >1 publications with HAAO and KYNU

Pathways associated with HAAO recombinant protein

 Products by Pathway  Pathway Diagram
 Histidine, Lysine, Phenylalanine, Tyrosine, Proline And Tryptophan Catabolism Pathway antibodies  Histidine, Lysine, Phenylalanine, Tyrosine, Proline And Tryptophan Catabolism Pathway Diagram
 L-kynurenine Degradation Pathway antibodies  L-kynurenine Degradation Pathway Diagram
 L-tryptophan Degradation III (eukaryotic) Pathway antibodies  L-tryptophan Degradation III (eukaryotic) Pathway Diagram
 L-tryptophan Degradation XI (mammalian, Via Kynurenine) Pathway antibodies  L-tryptophan Degradation XI (mammalian, Via Kynurenine) Pathway Diagram
 L-tryptophan Degradation To 2-amino-3-carboxymuconate Semialdehyde Pathway antibodies  L-tryptophan Degradation To 2-amino-3-carboxymuconate Semialdehyde Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 NAD Biosynthesis II (from Tryptophan) Pathway antibodies  NAD Biosynthesis II (from Tryptophan) Pathway Diagram
 NAD Biosynthesis II (from Tryptophan) Pathway antibodies  NAD Biosynthesis II (from Tryptophan) Pathway Diagram

Diseases associated with HAAO recombinant protein

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >2 publications with HAAO and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >2 publications with HAAO and Neoplasms, Experimental
 Inflammation Antibodies  >2 publications with HAAO and Inflammation
 Heart Defects, Congenital Antibodies  >1 publications with HAAO and Heart Defects, Congenital
 Heart Diseases Antibodies  >1 publications with HAAO and Heart Diseases
 Hyperplasia Antibodies  >1 publications with HAAO and Hyperplasia
 Necrosis Antibodies  >1 publications with HAAO and Necrosis

Organs/Tissues associated with HAAO recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with HAAO and Blood
 Brain Antibodies  >3 publications with HAAO and Brain
 Kidney Antibodies  >1 publications with HAAO and Kidney
 Intestine Antibodies  >1 publications with HAAO and Intestine
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