FCGR3A Recombinant Protein

Name: FCGR3A Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS204579
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204579

Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A), also known as CD16A. This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FCGR3A, Recombinant Protein

Full Product Name

FCGR3A, 18-208aa, Human, His tag, E Coli (Denatured)

Product Gene Name

FCGR3A recombinant protein

Product Synonym Names

Low affinity immunoglobulin gamma Fc region receptor III-A; CD16; CD16A; FCG3; FCGR3; FCGRIII; FCR-10; FCRIII; FCRIIIA; IGFR3

Sequence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMRT EDLPKAVVFL EPQWYRVLEK DSVTLKCQGA YSPEDNSTQW FHNESLISSQ ASSYFIDAAT VDDSGEYRCQ TNLSTLSDPV QLEVHIGWLL LQAPRWVFKE EDPIHLRCHS WKNTALHKVT YLQNGKGRKY FHHNSDFYIP KATLKDSGSY FCRGLFGSKN VSSETVNITI TQGLAVSTIS SFFPPGYQ

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 1M urea, 10% glycerol

Purity/Purification

> 90% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

26 kDa (228aa)

OMIM

X52645 mRNA

3D Structure

ModBase 3D Structure for P08637

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for FCGR3A recombinant protein

Immunology

Applications Tested/Suitable for FCGR3A recombinant protein

SDS-PAGE

Application Notes for FCGR3A recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for FCGR3A recombinant protein

Huizinga T W., et al. (1988) Nature. 333:667-669.; Nagarajan S., et al. (1995) J Biol Chem. 270:25762-25770.

Other Notes

Small volumes of FCGR3A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FCGR3A purchase

MBS204579 is a recombinant protein targeting FCGR3A. Also known as FCGR3A, 18-208aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FCGR3A. It may not necessarily be applicable to this product.

NCBI GI #

189083838

NCBI GeneID

2214

NCBI Accession #

NP_001121065

UniProt Primary Accession #

P08637

UniProt Secondary Accession #

Q53FJ0; Q53FL6; Q5EBR4; Q65ZM6; Q6PIJ0; A2N6W9

UniProt Related Accession #

P08637

GenBank Nucleotide #

NM_001127593.1

NCBI Official Full Name

low affinity immunoglobulin gamma Fc region receptor III-A isoform c

NCBI Official Synonym Full Names

Fc fragment of IgG receptor IIIa

NCBI Official Symbol

FCGR3A

NCBI Official Synonym Symbols

CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA

UniProt Protein Name

Low affinity immunoglobulin gamma Fc region receptor III-A

UniProt Synonym Protein Names

CD16a antigen; Fc-gamma RIII-alpha; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc receptor III-2; CD_antigen: CD16a

Protein Family

Low affinity immunoglobulin gamma Fc region receptor

UniProt Gene Name

FCGR3A

UniProt Synonym Gene Names

CD16A; FCG3; FCGR3; IGFR3; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa

NCBI Protein Information

low affinity immunoglobulin gamma Fc region receptor III-A

NCBI Summary for FCGR3A

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for FCGR3A

Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.

Research Articles on FCGR3A

1. The FCGR3A V allele correlated with the occurrence of late-onset neutropenia following rituximab treatment in patients with rheumatic diseases

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FCGR3A recombinant protein

Reference Product	PubMed Publications
FCGR3B recombinant protein	>88 publications with FCGR3A and FCGR3B
FCGR1A recombinant protein	>12 publications with FCGR3A and FCGR1A
SYK recombinant protein	>4 publications with FCGR3A and SYK
PIK3CA recombinant protein	>2 publications with FCGR3A and PIK3CA
CD2 recombinant protein	>1 publications with FCGR3A and CD2

Pathways associated with FCGR3A recombinant protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
FCGR Activation Pathway antibodies	FCGR Activation Pathway Diagram
Fc Gamma R-mediated Phagocytosis Pathway antibodies	Fc Gamma R-mediated Phagocytosis Pathway Diagram
Fc Gamma R-mediated Phagocytosis Pathway antibodies	Fc Gamma R-mediated Phagocytosis Pathway Diagram
Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies	Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies	Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Leishmaniasis Pathway antibodies	Leishmaniasis Pathway Diagram
Leishmaniasis Pathway antibodies	Leishmaniasis Pathway Diagram

Diseases associated with FCGR3A recombinant protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>38 publications with FCGR3A and Necrosis
Cardiovascular Diseases Antibodies	>28 publications with FCGR3A and Cardiovascular Diseases
Inflammation Antibodies	>27 publications with FCGR3A and Inflammation
Breast Neoplasms Antibodies	>22 publications with FCGR3A and Breast Neoplasms
Leukemia Antibodies	>19 publications with FCGR3A and Leukemia
Thrombocytopenia Antibodies	>17 publications with FCGR3A and Thrombocytopenia
Kidney Diseases Antibodies	>16 publications with FCGR3A and Kidney Diseases
Neoplasms, Experimental Antibodies	>16 publications with FCGR3A and Neoplasms, Experimental
Disease Models, Animal Antibodies	>13 publications with FCGR3A and Disease Models, Animal
Anemia Antibodies	>8 publications with FCGR3A and Anemia

Organs/Tissues associated with FCGR3A recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>229 publications with FCGR3A and Blood
Kidney Antibodies	>19 publications with FCGR3A and Kidney
Lung Antibodies	>9 publications with FCGR3A and Lung
Ovary Antibodies	>7 publications with FCGR3A and Ovary
Liver Antibodies	>7 publications with FCGR3A and Liver
Spleen Antibodies	>3 publications with FCGR3A and Spleen
Brain Antibodies	>3 publications with FCGR3A and Brain
Intestine Antibodies	>1 publications with FCGR3A and Intestine
Thyroid Antibodies	>1 publications with FCGR3A and Thyroid
Pancreas Antibodies	>1 publications with FCGR3A and Pancreas